Quantitative analysis of oxidative DNA damage induced by high-voltage pulsed discharge with cavitation

Kudo, Ken-Ichi; Ito, Hironori; Ihara, Satoshi; Terato, Hiroaki

doi:10.1016/j.elstat.2014.10.010

Cited by 17 publications

(8 citation statements)

References 41 publications

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“…Nucleic acids (including DNA and RNA) must be very sensitive to the effects of cavitation. A decrease in the relative viscosity of the DNA solution by ultrasonic cavitators is detected after just one minute of treatment; with increasing exposure, the relative viscosity of the DNA solution continues to decrease [49]. This decrease is persistent; the sonicated solution does not change the viscosity even after 24 ... 48 hours of sedimentation.…”

Section: Tr R Tmentioning

confidence: 90%

Mechanism and Synergy Effect of the Hybrid Water Disinfection Process Using Electric Discharges Combined with Chlorination

Malyushevskaya,

Koszelnik,

Mitryasova

et al. 2024

Preprint

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An analysis of the physical and chemical phenomena accompanying the electrical discharges was carried out, principal factors inactivating microorganisms is studied. Characteristic factors of an electric discharge in cavitation mode providing a synergistic effect when disinfecting water with a discharge and chemical reagents are identified in order of importance. As a result of the integral action of cavitation, the inactivation of bacteria is intensified both due to the emergence of chem-ically active particles and due to local shock waves, acoustic currents and ultraviolet radiation in the area of cavitating bubbles. The similarity of cavitation processes in water systems implemented by underwater electric discharges and with the ultrasound has been experimentally proved. The main advantage of electric discharge cavitation in comparison with ultrasonic one is the wide band of ultrasonic frequencies of radiation inherent in electric discharge, high intensity and power of cav-itation processes, and, accordingly, the possibility of a significant increase in the volume of the disinfected liquid. The study enable better understanding and prediction of the effects that occur during a high-voltage underwater electrical discharge and have a bactericidal effect.

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Section: Tr R Tmentioning

confidence: 90%

Mechanism and Synergy Effect of the Hybrid Water Disinfection Process Using Electric Discharges Combined with Chlorination

Malyushevskaya,

Koszelnik,

Mitryasova

et al. 2024

Preprint

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“…Proteins and enzymes have been shown to denature at 1.2 V vs Ag/AgCl in water 53 and DNA undergoes oxidative stress at similar potentials. 54 TGA-CdSe QDs have exhibited low oxidation potential at ≈ 0.9 V vs Ag/AgCl with TPrA 55 and sulphite. 56 Therefore, luminophores that luminesce at relatively low potentials are highly desirable for ECL biosensor applications.…”

Section: Cadmium Nps As Luminophoresmentioning

confidence: 98%

Evolution of nanomaterial Electrochemiluminescence luminophores towards biocompatible materials

O’Connor

Dennany²,

O’Reilly³

2023

Bioelectrochemistry

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“…The method based on plasma generated in HCB has great potential, while relevant research is scanty. Treatment of E. coli cells with pulsed discharges with cavitation bubbles leads to the formation of reactive oxygen species (ROS) from the generated plasma, which decreases the viability of the cells and induces DNA damage in E. coli [14] . Ihara et al [15] analyzed the impact of solution conductivity and discharge frequency of discharge plasma formed in HCB on water treatment efficiency.…”

Section: Introductionmentioning

confidence: 99%

Plasma Generated in Hydrodynamic Cavitation Bubbles for the Preparation of Plasma Activated Water

2023

Mod Plasma Med

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Objective: In recent years, the medical applications of plasma activated water (PAW) have attracted growing interest. PAW can be prepared using plasma generated by hydrodynamic cavitation bubbles (HCB). To facilitate this application, the current study was performed to investigate the efficiency of plasma generation in HCB. Methods:Based on the plasma generated in HCB, an experimental system has been constructed. We measured the characteristics of the cavitating flow, including pressure, temperature, and water flow rate, and estimated the system and cavitation power consumptions. High-speed images of cavitating flow were obtained to examine the evolution of the cavitation zone. Images of discharge emission at various velocities were captured to identify the location of electrodes. In addition, optical emission spectra were examined to determine the type of reactive species. H 2 O 2 concentration and energy efficiency were measured and analyzed. Results:In this experiment, the system power consumption was 1.2W. The highest cavitation power consumption was 50.4W and increased with the elevation of throat velocities. The processing findings of high-speed images revealed that the cavitation characteristic length was essential for plasma generation and was necessary for establishing the location of electrodes. In addition, the UV-Vis emission spectra of the plasma discharge demonstrated that the hydroxyl radical •OH was formed in situ and that cavitation increased the yield of •OH. H 2 O 2 was the principal active component of PAW. Plasma generated in HCB produced H 2 O 2 with a high energy efficiency of 77.0mol/kWh. Conclusion:Plasma generated in HCB may provide a viable and cost-effective alternative method for PAW preparation.

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Quantitative analysis of oxidative DNA damage induced by high-voltage pulsed discharge with cavitation

Cited by 17 publications

References 41 publications

Mechanism and Synergy Effect of the Hybrid Water Disinfection Process Using Electric Discharges Combined with Chlorination

Mechanism and Synergy Effect of the Hybrid Water Disinfection Process Using Electric Discharges Combined with Chlorination

Evolution of nanomaterial Electrochemiluminescence luminophores towards biocompatible materials

Plasma Generated in Hydrodynamic Cavitation Bubbles for the Preparation of Plasma Activated Water

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