Quantitative Analysis of Pantoprazole Sodium Sesquihydrate in Bulk and Solid Dosage Form via UV-Spectrophotometric Method

Rafiq, Asma; Gul, Somia; Ajaz, Arzoo; Fatima, Sakina; Mirza, Agha Zeeshan

doi:10.5530/ijper.54.2.51

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…1). The absorbance was measured at 288 nm, and the concentration of pantoprazole was determined in accordance with a validated UV/Vis spectrophotometric method (19). The linearity was confirmed in the tested pantoprazole concentration range (R 2 = 0.9989).…”

Section: Uv/vis Spectrophotometrymentioning

confidence: 92%

Influence of Storage Conditions on the Pantoprazole Dissolution Profile for Gastro-Resistant Tablet Formulations

Panić,

Todorović,

Jonaš

et al. 2023

Dissolution Technol.

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Generic formulations share the same active pharmaceutical ingredient (API), but differences in excipients can impact the quality and efficacy of formulations. In this study, four gastro-resistant pantoprazole tablet formulations were selected from the Serbian drug market to compare their dissolution profiles. The influence of high and low humidity on disintegration and dissolution was examined. The tablets were removed from the primary packaging and packed in plastic boxes, which were then placed in the desiccator with low (30%) and high (75%) humidity conditions for 1 week to simulate storing medicines in weekly pill organizers. Dissolution, disintegration, and uniformity of content were analyzed according to the 10 th European Pharmacopoeia. Pantoprazole content was determined using UV-Vis spectrophotometry. Dissolution profiles were compared with one-way analysis of variance and similarity factor analysis (f 2 ). Although a difference was detected in the dissolution profiles of pantoprazole tablets, the overall dissolution rate was satisfactory for all formulations in all conditions tested. After being exposed to high humidity, two formulations failed to meet the requirements for disintegration due to the enteric coating being damaged during the acid stage of the test. This could lead to the absence of therapeutic effect. Therefore, patients should be advised to keep their pantoprazole tablets away from high humidity, preferably in the original packaging.

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Section: Uv/vis Spectrophotometrymentioning

confidence: 92%

Influence of Storage Conditions on the Pantoprazole Dissolution Profile for Gastro-Resistant Tablet Formulations

Panić,

Todorović,

Jonaš

et al. 2023

Dissolution Technol.

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show abstract

“…Content of pantoprazole in capsules and concentration of pantoprazole in dissolution samples were determined using a previously published UV/Vis spectrophotometry method [ 35 ]. Measurements were performed at a wavelength of 288 nm.…”

Section: Methodsmentioning

confidence: 99%

Compounding of Liquid and Solid Dose Adjustable Formulations with Pantoprazole: Comparison of Stability, Applicability and Suitability

et al. 2023

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Pantoprazole is a model substance that requires dosage form adjustments to meet the needs of all patients. Pediatric pantoprazole formulations in Serbia are mostly compounded as capsules (divided powders), while in Western Europe liquid formulations are more common. The aim of this work was to examine and compare the characteristics of compounded liquid and solid dosage forms of pantoprazole. Three syrup bases were used: a sugar-free vehicle for oral solution (according to USP43-NF38), a vehicle with glucose and hydroxypropyl cellulose (according to the DAC/NRF2018) and a commercially available SyrSpend Alka base. Lactose monohydrate, microcrystalline cellulose and a commercially available capsule filler (excipient II, composition: pregelatinized corn starch, magnesium stearate, micronized silicon dioxide, micronized talc) were used as diluents in the capsule formulations. Pantoprazole concentration was determined by the usage of the HPLC method. Pharmaceutical technological procedures and microbiological stability measurements were performed according to the recommendations of the EP10. Although dose appropriate compounding with pantoprazole is suitable using both liquid vehicles as well as solid formulations, chemical stability is enhanced in solid formulation. Nevertheless, according to our results, if liquid formulation is a pH adjusted syrup, it could be safely kept in a refrigerator for up to 4 weeks. Additionally, liquid formulations could be readily applied, while solid formulation should be mixed with appropriate vehicles with higher pH values.

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Design and synthesis of high quantum yield doped carbon nano probe derived from household sources for sensing of the anti-GERD drug pantoprazole

El-Maghrabey,

El Hamd,

Al-Khateeb

et al. 2025

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Quantitative Analysis of Pantoprazole Sodium Sesquihydrate in Bulk and Solid Dosage Form via UV-Spectrophotometric Method

Cited by 3 publications

References 2 publications

Influence of Storage Conditions on the Pantoprazole Dissolution Profile for Gastro-Resistant Tablet Formulations

Influence of Storage Conditions on the Pantoprazole Dissolution Profile for Gastro-Resistant Tablet Formulations

Compounding of Liquid and Solid Dose Adjustable Formulations with Pantoprazole: Comparison of Stability, Applicability and Suitability

Design and synthesis of high quantum yield doped carbon nano probe derived from household sources for sensing of the anti-GERD drug pantoprazole

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