Quantitative Analysis of Phospholipid Composition by High Performance Liquid Chromatography

Itoh, Toshihiro; Murui, Tateo; Asano, Sadahiko; Arakawa, Akiko; Ushikusa, Toshiaki; Sakuma, Rie; Sono, Ryoji; Tohdo, Hirofumi; Hirata, Yosiaki; Nishide, Tsutomu; Yamaguchi, Takashi; Morita, Hiroshi

doi:10.5650/jos1956.41.1171

J. Jpn. Oil. Chem. Soc.

1992

DOI: 10.5650/jos1956.41.1171

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Quantitative Analysis of Phospholipid Composition by High Performance Liquid Chromatography

Toshihiro Itoh

Tateo Murui

Sadahiko Asano³

et al.

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“…The hepatic microsomal PI was determined by an HPLC method (Toyo Kensa Center Co., Ltd, Shizuoka, Japan) 22) . The preparation of hepatic subcellular fractions was conducted as described previously 14) .…”

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confidence: 99%

Effect of Dietary Phosphatidylinositol on Cholesterol Metabolism in Zucker (fa/fa) Rats

et al. 2009

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Recent studies have shown that dietary phospholipids, especially phosphatidylcholine and phosphatidylserine, have various beneficial biological effects. However, there are not enough data concerning the physiological function of dietary phosphatidylinositol (PI). The metabolic syndrome, a cluster of metabolic abnormalities such as dyslipidemia, diabetes mellitus, and hypertension, is widespread and increasingly prevalent diseases in industrialized countries. In the present study, we evaluated that the effect of dietary PI on cholesterol metabolism in metabolic syndrome model Zucker (fa/fa) rats. For 4 weeks, rats were fed semisynthetic diets containing either 7% soybean oil or 5% soybean oil plus 2% PI. Dietary PI prevented the mild hypercholesterolemia and hepatic cholesterol accumulation in Zucker (fa/fa) rats. These effects were attributable to an increased fecal bile acid excretion and to the tendencies of decreased ACAT1 mRNA level and increased CYP7A1 mRNA level in the liver. Additionally, dietary PI markedly increased microsomal PI content in the liver of Zucker (fa/fa) rats. Our study suggests that dietary PI normalizes cholesterol metabolism through the enhancement of fecal bile acid excretion in the metabolic syndrome model rats.

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Effect of Dietary Phosphatidylinositol on Cholesterol Metabolism in Zucker (fa/fa) Rats

et al. 2009

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Quantitative Analysis of Phospholipid Composition by High Performance Liquid Chromatography

Cited by 1 publication

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Effect of Dietary Phosphatidylinositol on Cholesterol Metabolism in Zucker (fa/fa) Rats

Effect of Dietary Phosphatidylinositol on Cholesterol Metabolism in Zucker (fa/fa) Rats

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