Quantitative analysis of polypropyleneglycol mixtures by desorption/ionization on porous silicon mass spectrometry

Okuno, S.; Wada, Yoshinao; Arakawa, Ryuichi

doi:10.1016/j.ijms.2004.10.022

Cited by 32 publications

(28 citation statements)

References 38 publications

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“…This is consistent with experiments performed by Koo et al using a TOF mass analyzer [34]. On the other hand, when graphite was desorbed from silicon, the mass distribution of the observed spectra was constant (Figure 5d-f), suggesting that fragmentation was suppressed when silicon is used as a sample support, which is also consistent with results reported previously [35,36]. LDI-FTMS of anthracene was performed by direct laser desorption from both stainless steel and silicon surfaces, and by matrix assisted laser desorption/ionization (MALDI) using DHB as a matrix (Figure 6).…”

Section: Resultssupporting

confidence: 92%

Laser desorption/ionization fourier transform mass spectrometry of thin films deposited on silicon by plasma polymerization of acetylene

Miladinović

Vriendt

Robotham

et al. 2010

J. Am. Soc. Mass Spectrom.

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Thin films deposited on silicon substrate by three different methods of plasma polymerization of acetylene were analyzed by direct laser desorption/ionization Fourier transform mass spectrometry. High-resolution mass spectra showed the presence of carbon clusters and hydrocarbon oligomers in different relative abundances. During unipolar and continuous discharge polymerization of acetylene-hydrogen gas mixtures, quadrupole mass spectra of the plasma constituents showed the presence of molecular species with m/z lower than 100 -mainly peaks of C 4 H 2 and C 6 H 2 . Films produced had smooth surfaces and the corresponding LDI-FTMS spectra displayed only carbon cluster signals in the positive ion mode and both hydrocarbon and carbon cluster signals (with much higher relative abundance of carbon cluster signals) in the negative ion mode. Alternatively, during bipolar discharge with either higher acetylene gas flux (Ͼ40 cm 3 /min) or longer deposition times (Ͼ10 min), quadrupole mass spectra of the plasma constituents showed signals corresponding to polycyclic aromatic hydrocarbons (PAH) with m/z higher than 100. SEM pictures of the bipolar thin films demonstrated the presence of "flower" structures and nanoparticles developed on the surface. LDI-FTMS spectra of such thin films showed either total absence or lower relative abundance of carbon cluster signals, compared with hydrocarbon signals. (J Am Soc Mass Spectrom 2010, 21, 411-420)

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Section: Resultssupporting

confidence: 92%

Laser desorption/ionization fourier transform mass spectrometry of thin films deposited on silicon by plasma polymerization of acetylene

Miladinović

Vriendt

Robotham

et al. 2010

J. Am. Soc. Mass Spectrom.

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“…DIOS-MS has been widely used for the analysis of a number of compounds including peptides, 14 small organic molecules, [15][16][17] and synthetic polymers. 18 , 19 However, DIOS has a limitation in that the signal intensity is much less than that of MALDI. In order to improve ionization efficiency, direct addition of ionsequestering agents, such as ammonium citrate or perfluorinated surfactants of perfluorooctanesulfonic acid, to the sample significantly enhanced DIOS ion signal intensities.…”

mentioning

confidence: 99%

Signal enhancement on laser desorption/ionization using alkali dihydroxybenzoic acid salts as cationizing agents

Arakawa

Miyake

Okuno

et al. 2006

Rapid Comm Mass Spectrometry

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Signal enhancement on laser desorption/ionization using alkali dihydroxybenzoic acid salts as cationizing agentsMatrix-assisted laser desorption/ionization (MALDI), Biopolymers, synthetic polymers and metal complexes have been successfully analyzed by MALDI-mass spectrometry (MS). [3][4][5][6] For measurement by MALDI-MS, it is necessary that UV-absorbing organic molecules, referred to as the matrix and target analyte, be mixed and deposited on a sample target. This leads to the production of a high intensity of matrix-derived ions and cluster ions in the low-mass region of MALDI spectra and these ions can sometimes interfere with the characterization of low-mass compounds. Various MALDI preparations have been designed to suppress ions from the matrix and enhance analyte ions. [7][8][9][10][11][12][13] At appropriate matrix-to-analyte mixing ratios, the matrix-related ions in MALDI spectra are suppressed.7 Addition of iodine to the matrix reportedly suppresses the signal intensities of the matrix-related ions and increases the analyte ions. 8 Lithium 2,5-dihydroxybenzoate (LiDHB) was shown to be an effective matrix for saturated hydrocarbons and lipids that had previously been difficult to ionize. 9A pre-prepared sample target that was coated with a thin layer of a-cyano-4-hydroxycinnamic acid (CHCA) and nitrocellulose was shown to suppress CHCA signals with no significant loss of analyte sensitivity. 10A sol-gel-derived dihydroxybenzoic acid thin film was reported to facilitate the mass analysis of analytes by laser desorption/ionization with a matrix interference-free background. 11Siuzdak and coworkers developed a matrix-free ionization method and named it laser desorption/ionization on silicon (DIOS We studied the suitability of 2,5-dihydroxybenzoic acid (DHB) salts, NaDHB, LiDHB and NH 4 DHB, as cationizing agents for the analysis of synthetic polymers. We focused on the suppression of matrix-related ions and the enhancement of analyte signals in MALDI and DIOS measurements.Acetonitrile, ethanol, 46% HF, DHB, NaI, LiBr, and CH 3 COONH 4 were purchased from Wako Pure Chemicals (Osaka, Japan). The Na-, Li-and NH 4 -DHB salts were also supplied by Wako Pure Chemicals. Poly-1,4-butyleneglycol adipate acid (BGAA, Mw 1000) was from Sigma-Aldrich (Milwaukee, WI, USA); angiotensin and insulin (human) were from Bachem AG (Bubendorf, Switzerland). Industrial-grade polycaprolactonediol (PCL, Mw 300) and nonylphenolpolyethoxyerate (NP, Mw 2400) were used. Polyethylene glycol (PEG, Mw 1000) was obtained from Wako Pure Chemicals, and polymethylmethacrylate (PMMA, Mw 1400) from Shodex Standard (Shoko, Co., Tokyo, Japan). The structures of the synthetic polymers are shown in Scheme 1. The ntype silicon wafers were obtained from Sumitomo Mitsubishi Silicon Corporation (Tokyo, Japan).DIOS chips were prepared as described previously.8 Briefly, n-type silicon (1 0 0) wafers of resistivity r ¼ 0.008-0.02 Vcm were used. They were anodically etched in a 1:1 (v/v) solution of EtOH/HF (46%) under exposure to white light using a 100 ...

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“…Furthermore, with experimental optimization, NALDI was proven to be capable of performing quantitative analysis [62], therefore opening new opportunities for studying enzyme activity and on-tissue medical imaging.…”

Section: Naldi In Qualitative Quantitative and Imaging Analysis Of Smamentioning

confidence: 99%

Nanomaterial-Assisted Laser Desorption Ionization for Mass Spectrometry-Based Biomedical Analysis

Qiao

Liu

2010

Nanomedicine

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Nanomaterials have been widely used to assist laser desorption ionization of biomolecules for mass spectrometry analysis. Compared with classical matrix-assisted laser desorption ionization, strategies based on nanomaterial-assisted ionization generate a clean background, which is of great benefit for the qualitative and quantitative analysis of small biomolecules, such as therapeutic and diagnostic molecules. As label-free platforms, they have successfully been used for high-throughput enzyme activity/inhibition monitoring and also for tissue imaging to map in situ the distribution of peptides, metabolites and drugs. In addition to widely used porous silicon nanomaterials, gold nanoparticles can be easily chemically modified by thiol-containing compounds, opening novel interesting perspectives. Such functionalized nanoparticles have been used both as probes to extract target molecules and as matrices to assist laser desorption ionization for developing new enzyme immunoassays or for studying DNA hybridization. More recently, semiconductor nanomaterials or quantum dots acting as photosensitive centers to induce in-source redox reactions for proteomics and to investigate biomolecule oxidation for metabolomics have been shown to offer new analytical strategies.

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Quantitative analysis of polypropyleneglycol mixtures by desorption/ionization on porous silicon mass spectrometry

Cited by 32 publications

References 38 publications

Laser desorption/ionization fourier transform mass spectrometry of thin films deposited on silicon by plasma polymerization of acetylene

Laser desorption/ionization fourier transform mass spectrometry of thin films deposited on silicon by plasma polymerization of acetylene

Signal enhancement on laser desorption/ionization using alkali dihydroxybenzoic acid salts as cationizing agents

Nanomaterial-Assisted Laser Desorption Ionization for Mass Spectrometry-Based Biomedical Analysis

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