Quantitative analysis of polyvinyl alcohol on the surface of poly(d,l-lactide-co-glycolide) microparticles prepared by solvent evaporation method: effect of particle size and PVA concentration

Effect of Surfactants on Plasmid DNA Stability and Release from Poly (D,L-lactide-co-glycolide) Microspheres

“…It was proposed that the hydrophobic vinyl acetate part of the partially hydrolysed PVA acted as anchors at the DCM interface. Once it is entangled with PLGA, it becomes very difficult to be removed from the surface [19,20]. These entanglements could trap the pDNA leading to conformational change in the pDNA due to the shear stress [9].…”

Selective Laser Sintered Poly(L-Lactide)/Carbonated Hydroxyapatite Nanocomposite Scaffolds: A Bottom-up Approach

“…Thus, the higher PVA concentration of the continuous phase could lead to an increase in PVA molecule density at the O/W interface of the emulsion droplet, which might increase the amount of PVA on the droplet surface. Previous reports showed that the size of PLGA microspheres decreases with increasing PVA concentration in the external aqueous phase (Zambaux, Bonneaux et al 1998;Lee, Oh et al 1999;Sahoo, Panyam et al 2002). In the current study; however, this trend was not clear and it might be due to the high inherent viscosity (1.6 dL/g) and semicrystalline nature of the PLLA.…”

Preparation and evaluation of tilmicosin-loaded hydrogenated castor oil nanoparticle suspensions of different particle sizes

“…The finding that a higher concentration of PVA was required to prepare suspensions with smaller particles sizes is consistent with a number of previous reports, where the findings indicated that higher PVA concentrations resulted in smaller nanoparticles. 28,29 Moreover, adequate ultrasonication time is essential for preparing nanoparticles with a narrow particle size distribution. Notably, longer ultrasonication time did not result in decreased particle sizes when lower PVA concentrations were used.…”

“…The higher PVA concentration used to prepare the smaller nanoparticles may lead to an increase in PVA density at the oil-water interface of the emulsion droplet, which could increase the thickness on the particle surface. 29,30 A PVA layer at the surface of the nanoparticles can potentially shield the surface charge of the matrix and drugs. 31 Thus, it is reasonable to expect that less shielding, and therefore a higher ZP, would be observed from nanoparticles prepared with 0.2% PVA and 1% PVA.…”