Quantitative Analysis of Retinal Vasculature in Rhegmatogenous Retinal Detachment Based on Ultra-Widefield Fundus Imaging

Feng, Bingkai; Su, Wenxin; Chen, Qingshan; Gan, Run; Wang, Mingxuan; Wang, Jiantao; Zhang, Jiayi; Yan, Xiao‐Xin

doi:10.3389/fmed.2021.797479

Cited by 3 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most prevalent form of neurosensory retina separation from the retinal pigment epithelium (RPE) is the rhegmatogenous retinal detachment. This type of detachment disrupts the retinal vasculature leading to smaller vascular diameters, tortuosity, and vascular density ( 195 ). Capillary dilatation, hyperpermeability and fluorescein leakage have also been observed with fluorescein angiography on the detached retina, and have been proposed to originate from tissue hypoxia ( 196 , 197 ).…”

Section: Myopia-associated Conditions Showing Vascular Alterationsmentioning

confidence: 99%

Evidence of vascular involvement in myopia: a review

Benavente-Perez

2023

Front. Med.

View full text Add to dashboard Cite

The benign public perception of myopia (nearsightedness) as a visual inconvenience masks the severity of its sight-threatening consequences. Myopia is a significant risk factor for posterior pole conditions such as maculopathy, choroidal neovascularization and glaucoma, all of which have a vascular component. These associations strongly suggest that myopic eyes might experience vascular alterations prior to the development of complications. Myopic eyes are out of focus because they are larger in size, which in turn affects their overall structure and function, including those of the vascular beds. By reviewing the vascular changes that characterize myopia, this review aims to provide an understanding of the gross, cellular and molecular alterations identified at the structural and functional levels with the goal to provide an understanding of the latest evidence in the field of experimental and clinical myopia vascular research. From the evidence presented, we hypothesize that the interaction between excessive myopic eye growth and vascular alterations are tipping-points for the development of sight-threatening changes.

show abstract

Section: Myopia-associated Conditions Showing Vascular Alterationsmentioning

confidence: 99%

Evidence of vascular involvement in myopia: a review

Benavente-Perez

2023

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Sato et al reported the mean circulation time in detached and undetached areas, demonstrating a slower blood flow in detached ones 29 . Using ultrawide-field imaging and OCTA, Feng described qualitative and quantitative changes in retinal vasculature in both RRD and non-RRD areas 30 .…”

Section: Discussionmentioning

confidence: 99%

Baseline imaging characteristics and early structural changes in macula on rhegmatogenous retinal detachment

Quarta,

Gironi,

Ruggeri

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Animal models have demonstrated that structural changes affect the macula during peripheral rhegmatogenous retinal detachment. This study aimed to assess photoreceptors, retinal and choriocapillaris perfusion in non-macula involving rhegmatogenous retinal detachment by analyzing en-face images from structural OCTA segmented at the ellipsoid zone (EZ) level, calculating (1) “normalized” reflectivity as a surrogate biomarker of photoreceptor damage (2) perfusion density (PD), vessel length density (VLD) and vessel diameter index (VDI) of superficial capillary plexus (SCP) and deep capillary plexus (DCP) (3) perfusion density of choriocapillaris (PDCC). Twenty-one eyes affected by macula-on rhegmatogenous retinal detachment (RRD) were enrolled at the University “G. d’Annunzio”, Chieti-Pescara. The fellow unaffected eye was used as control. The mean age at the onset of RRD was 60.09 ± 10.22 (range 34–83). Compared with fellow eyes, we found lower EZ “normalized” reflectivity in macula-on (0.42 ± 0.15 in fellow eyes and 0.31 ± 0.09 in macula on p = 0.004). The affected eye was also characterized by impaired perfusion in SCP (17.26 ± 3.34% in macula on and 20.56 ± 3.62% in the fellow eye p = 0.004) and CC (50.21 ± 6.20% in macula on the eye and 57.43 ± 6.20% in the fellow eye p = 0.004). Macula-on rhegmatogenous retinal detachment has subclinical changes in photoreceptors, SCP, and CC. Future longitudinal studies should evaluate if early changes could impact post-operative macular function.

show abstract

“…Despite significant progress in the use of UFI for diagnosing and managing ocular diseases, current classification methods still have limitations. Many existing studies focus only on single diseases, such as diabetic retinopathy [ 4 , 5 , 6 , 7 ], glaucoma [ 8 ], or retinal detachment [ 9 , 10 , 11 ]. On the other hand, some studies have made attempts at classifying multiple diseases but limit their data to images containing only a single disease [ 12 , 13 ], making it less practical for real-world applications.…”

Section: Introductionmentioning

confidence: 99%

Discriminative-Region Multi-Label Classification of Ultra-Widefield Fundus Images

Pham,

Le,

Bum

et al. 2023

Bioengineering

View full text Add to dashboard Cite

Ultra-widefield fundus image (UFI) has become a crucial tool for ophthalmologists in diagnosing ocular diseases because of its ability to capture a wide field of the retina. Nevertheless, detecting and classifying multiple diseases within this imaging modality continues to pose a significant challenge for ophthalmologists. An automated disease classification system for UFI can support ophthalmologists in making faster and more precise diagnoses. However, existing works for UFI classification often focus on a single disease or assume each image only contains one disease when tackling multi-disease issues. Furthermore, the distinctive characteristics of each disease are typically not utilized to improve the performance of the classification systems. To address these limitations, we propose a novel approach that leverages disease-specific regions of interest for the multi-label classification of UFI. Our method uses three regions, including the optic disc area, the macula area, and the entire UFI, which serve as the most informative regions for diagnosing one or multiple ocular diseases. Experimental results on a dataset comprising 5930 UFIs with six common ocular diseases showcase that our proposed approach attains exceptional performance, with the area under the receiver operating characteristic curve scores for each class spanning from 95.07% to 99.14%. These results not only surpass existing state-of-the-art methods but also exhibit significant enhancements, with improvements of up to 5.29%. These results demonstrate the potential of our method to provide ophthalmologists with valuable information for early and accurate diagnosis of ocular diseases, ultimately leading to improved patient outcomes.

show abstract

Quantitative Analysis of Retinal Vasculature in Rhegmatogenous Retinal Detachment Based on Ultra-Widefield Fundus Imaging

Cited by 3 publications

References 35 publications

Evidence of vascular involvement in myopia: a review

Evidence of vascular involvement in myopia: a review

Baseline imaging characteristics and early structural changes in macula on rhegmatogenous retinal detachment

Discriminative-Region Multi-Label Classification of Ultra-Widefield Fundus Images

Contact Info

Product

Resources

About