Quantitative Analysis of Saponins in a Tea-Leaf Extract and Their Antihypercholesterolemic Activity

Matsui, Yoko; Kobayashi, Kazuo; Masuda, Hideki; Kigoshi, Hideo; Akao, Makoto; Sakurai, Hiroyuki; Kumagai, Hitomi

doi:10.1271/bbb.90003

Cited by 25 publications

(21 citation statements)

References 14 publications

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“…Several studies showed that saponins compound from various sources can lower serum cholesterol levels in animals and humans. Matsui et al (2009) reported that saponins of tea leaf extracts have antihiperkolesterolemia activity by 72% and the addition of 0.5% saponin on high cholesterol feed can inhibit the increasing serum cholesterol levels. Saponins also stimulate the reduction of cholesterol and triglycerides in the liver and increases cholesterol excretion in feces.…”

Section: Cholesterol Content In Blood Of Dairy Goatsmentioning

confidence: 99%

Milk Quality of Dairy Goat by Giving Feed Supplement as Antioxidant Source

Mardalena

Warly

Nurdin

et al. 2011

J. Indonesian Trop. Anim. Agric.

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Free radical levels can be higher than the level of endogenous antioxidants in the body so that uncomfortable conditions in the body of dairy goats could happen. To anticipate this uncomfortable conditions will be given feed supplement (FS) as source of antioxidants (AOX). FS contain mixture pineapple rind meal and antioxidant minerals (AOXM) each 25 ppm Zn and 10 ppm Cu. This experiment was carried out to investigate the effect of feed supplements as antioxidant source on milk quality of dairy goats. Sixteen Etawah dairy goats in the second lactation were used in the experiment that conducted using randomized block design with 4 treatments and 4 replicates. The treatments were R0 (grass + concentrate), R1 (R0 + FS containing 0.04 % AOX), R2 (R0 + FS containing 0.06% AOX), R3 (R0 + FS containing 0.08 % AOX). The data collected were analyzed using Anova. The result of phytochemicals analysis indicated that feed supplement contained flavonoid, polyphenols, sesqiuterpen, mopnoterpen, steroids, quinones and saponins. The results of study showed that there were difference (p<0.05) among treatments on blood and milk cholesterol and milk lactose, but there were no difference (P>0.05) on milk yield, milk fat, milk protein and milk antioxidant. The conclusion of this study was the feed supplements containing 0.08 AOX produced the best response to milk quality of dairy goats.

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Section: Cholesterol Content In Blood Of Dairy Goatsmentioning

confidence: 99%

Milk Quality of Dairy Goat by Giving Feed Supplement as Antioxidant Source

Mardalena

Warly

Nurdin

et al. 2011

J. Indonesian Trop. Anim. Agric.

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“…In addition, cellulose, pectin, and agar, which are also rich in many Chinese herbal medicines, can reduce the absorption of cholesterol by forming a complex with cholate to impede the formation of cholesterol microparticles in the intestine [3, 4]. …”

Section: Inhibiting the Intestinal Absorption Of Cholesterolmentioning

confidence: 99%

“…Fr2-3 induced a decrease in the liver cholesterol and triglyceride levels and an increase in the fecal excretion of cholesterol [4]. …”

Section: Inhibiting the Intestinal Absorption Of Cholesterolmentioning

confidence: 99%

Lipid-Regulating Effect of Traditional Chinese Medicine: Mechanisms of Actions

Bei

Guo

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese medicine (TCM) has been increasingly used for the treatment of dyslipidemia and cardiovascular disease. Recently, much progress has been made in studies on the mechanisms of action of the lipid-regulating effect of TCM in animal experiments. Current researches showed that the lipid-regulating effect of TCM may be related to the following actions: (1) inhibiting intestinal absorption of lipids; (2) reducing the biosynthesis of endogenous lipids; (3) increasing the catabolism of lipid, sterol substances in live system; (4) increasing the secretion of sterol substances in live system; (5) regulating transcription factors related to lipid metabolism. This paper provides an overview of the recent advances and discusses their implications in future development of lipid-lowering drugs from TCM.

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“…Tea saponin (TS) is a mixture of oleanane‐type pentacyclic triterpene (OPT) saponins extracted from Theaceae camellia plants. It has high surface activity as well as multiple biological properties, such as antiinflammatory (Sagesaka‐Mitane et al, ), antibiosis (Chattopadhyay et al, ), antioxidant (Sur, Chaudhuri, Vedasiromoni, Gomes, & Ganguly, ), antihypertensive (Sagesaka‐Mitane, Sugiura, Miwa, Yamaguchi, & Kyuki, ), antihypercholesterolemic (Matsui et al, ), and alcohol dehydrogenase (Varughese et al, ) activity, so TS has been widely applied in medicine, commodities, pesticides, construction materials, food industry, and so on. Every year, however, tens of thousands of tons of camellia dregs are wasted, which contains 15–20% TS.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Natural Tea‐Saponin‐Based Succinic Acid Sulfonate as Anionic Foaming Agent

Zhao

Deng

Wang

et al. 2018

J Surfact & Detergents

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Tea saponin (TS) is a relatively inexpensive natural nonionic surfactant extracted from parts of tea plants, which can be modified into an anionic surfactant to achieve better surface activity. In this paper, the synthesis of TS‐based succinic acid sulfonate as an anionic foaming agent is described. TS used as the hydrophobic source was modified by maleic anhydride (MAH) and then reacted with sodium bisulfite. Orthogonal experiment of a 2‐step reaction was designed and performed, resulting in 9 kinds of succinic acid tea‐saponin sulfonate (STS). 4‐Dimethylaminopyridine and tetrabutylammonium bromide were, respectively, used as catalyst for the esterification with MAH and the sulfonation with sodium bisulfite. During the synthesis process, N,N‐dimethylformamide was employed as the solvent and ethyl acetate as the extractant. The molecular structure of STS was confirmed by infrared spectroscopy and mass spectrometry. The foaming property of STS was investigated through comparison with different kinds of common surfactants. The results show great prospects of these environmentally friendly anionic surfactants.

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Quantitative Analysis of Saponins in a Tea-Leaf Extract and Their Antihypercholesterolemic Activity

Cited by 25 publications

References 14 publications

Milk Quality of Dairy Goat by Giving Feed Supplement as Antioxidant Source

Milk Quality of Dairy Goat by Giving Feed Supplement as Antioxidant Source

Lipid-Regulating Effect of Traditional Chinese Medicine: Mechanisms of Actions

Synthesis of Natural Tea‐Saponin‐Based Succinic Acid Sulfonate as Anionic Foaming Agent

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