Quantitative Analysis of Termination of Vagally Induced Canine Atrial Fibrillation by Mutual Information

Shimizu, Shuichi; Osaka, Motohisa; Saitoh, Hirokazu; Atarashi, Hirotsugu; Takano, Teruo

doi:10.1253/jcj.65.111

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…[16][17][18] DF of vagally induced AF decreases markedly when vagal stimulation is re- duced or stopped. 3,19 In our study, the DF of the atria decreased with lidocaine until conversion to sinus rhythm. Furthermore, organization remained prominent in the LA compared with the RA throughout the conversion.…”

Section: Discussionsupporting

confidence: 45%

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Lidocaine Converts Acute Vagally Associated Atrial Fibrillation to Sinus Rhythm in German Shepherd Dogs with Inherited Arrhythmias

Pariaut

Moı̈se

Koetje

et al. 2008

Veterinary Internal Medicne

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Background: Lidocaine is most frequently used to treat ventricular arrhythmias. However, lidocaine may have an antiarrhythmic effect for certain supraventricular arrhythmias.Hypothesis: We hypothesized that lidocaine would be effective in converting experimentally induced atrial fibrillation (AF) to sinus rhythm and that a decrease in the dominant frequency (DF) and an increase in the organization as judged by the spectral entropy (SE) would occur over the course of the conversion.Animals: Seven German Shepherd (GS) Dogs. Methods: Dogs were anesthetized with fentanyl and pentobarbital. AF was induced with standard pacing protocols while left and right atrial monophasic action potentials (MAP) were recorded. The power spectra from the MAP recordings were analyzed to determine DF and SE during treatment with boluses of 2 mg/kg lidocaine.Results: Lidocaine converted AF to sinus rhythm in all dogs and all episodes (n 5 19). Conversion time was 27-87 seconds. After atropine, sustained AF was not induced; however, 5 episodes of atrial tachycardia resulted, and 3 were converted with lidocaine. Frequency domain analysis of 12 conversion sequences showed that left and right DF of the MAP signals decreased from the time of injection to conversion to sinus rhythm (P o .001). Mean SE indicated a gradient between the left and right atria (P 5 .003) that did not change during conversion.Conclusions and Clinical Importance: Vagally associated AF in GS dogs is terminated with lidocaine. Lidocaine is likely an effective treatment in clinical dogs with vagally associated AF.

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Section: Discussionsupporting

confidence: 45%

“…Conversion to sinus rhythm in these studies demonstrated a slowing of atrial electrical activity (DF) and an increase in the organization 16–18 . DF of vagally induced AF decreases markedly when vagal stimulation is reduced or stopped 3,19 . In our study, the DF of the atria decreased with lidocaine until conversion to sinus rhythm.…”

Section: Discussionsupporting

confidence: 44%

Lidocaine Converts Acute Vagally Associated Atrial Fibrillation to Sinus Rhythm in German Shepherd Dogs with Inherited Arrhythmias

Pariaut

Moı̈se

Koetje

et al. 2008

Veterinary Internal Medicne

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“…After RFCA, however, AF was no longer inducible in the presence of vagal stimulation 19 . The discrete peak of the power spectrum of vagally induced AF shifted from HF to LF after the cessation of vagal stimulation, and AF then ceased 21 . In goat experimental models, the recovery time of atrial ERP shortening following atrial rapid pacing was lengthened in the high vagal tone group compared with those in the low vagal tone group 22 .…”

Section: Discussionmentioning

confidence: 97%

Role of Autonomic Tone in the Initiation and Termination of Paroxysmal Atrial Fibrillation in Patients Without Structural Heart Disease

Tomita

Takei

Saikawa

et al. 2003

Cardiovasc electrophysiol

105

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“…Spontaneous termination of AF occurring without any appreciable increase in the mean FCL indicates that maintenance of this type of AF is not dependent on multiple wavelets and may instead depend on focal mechanisms related to automatic activities from the pulmonary veins. 18 …”

Section: Mechanism Of Termination Of Afmentioning

confidence: 99%

Role of Fibrillation Cycle Length in Spontaneous and Drug-Induced Termination of Human Atrial Fibrillation-Spectral Analysis of Fibrillation Waves From Surface Electrocardiogram-

Fujiki

Sakabe

Nishida

et al. 2003

Circ J

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persistently rapid rate of atrial excitation produces a progressive shortening of the atrial effective refractory period and promotes the perpetuation of atrial fibrillation (AF); 1,2 however, most paroxysmal AF terminates spontaneously within a few days despite the presence of atrial remodeling. Termination of human AF with class I antiarrhythmic drugs is preceded by an increase in fibrillation cycle length (FCL), and a failure to increase the FCL correlates with a failure to terminate the AF with medication. 3 In canine models of AF, the mapping data suggest that the increase in FCL induced by antiarrhythmic drugs may relate to fusion of wavelets, an increase in the size of reentry circuits, a decrease in circuit number and finally, termination of AF. 4 Compared with drug-induced termination, the mechanism of spontaneous termination of human AF is still unclear. It is difficult to obtain intracardiac recordings just prior to spontaneous termination of paroxysmal AF for analysis of the fibrillation waves because spontaneous

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Quantitative Analysis of Termination of Vagally Induced Canine Atrial Fibrillation by Mutual Information

Cited by 4 publications

References 19 publications

Lidocaine Converts Acute Vagally Associated Atrial Fibrillation to Sinus Rhythm in German Shepherd Dogs with Inherited Arrhythmias

Lidocaine Converts Acute Vagally Associated Atrial Fibrillation to Sinus Rhythm in German Shepherd Dogs with Inherited Arrhythmias

Role of Autonomic Tone in the Initiation and Termination of Paroxysmal Atrial Fibrillation in Patients Without Structural Heart Disease

Role of Fibrillation Cycle Length in Spontaneous and Drug-Induced Termination of Human Atrial Fibrillation-Spectral Analysis of Fibrillation Waves From Surface Electrocardiogram-

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