Quantitative analysis of the cerebral cortex. II. A method for analysing basal dendritic plexuses

Colon, E. J.; Smit, G.J.

doi:10.1016/0006-8993(70)90477-4

Cited by 10 publications

(4 citation statements)

References 12 publications

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“…CROME, COWIE and (GREENFELD 1958). SLATER (1966), demonstrated significant differences between normal and mongoloid brainstem, cerebellum and cerebrum.…”

Section: Introductionmentioning

confidence: 94%

“…Conspicuous smallness of the cerebellum and the brainstem, in comparison with the cerebrum as a whole, I t was the aim of this study to analyse the quantitative structure of the cerebral cortex of mongoloid patients in relation to the normal adult cortex. In a former study (COLON, 1971) a description of the human isocortex, concerning nuclear volume and neuron number as a function of depth below the pial surface, was presented. Four cortical areas (10, 17, 24, 4 of BROD-MANN) of four traffic victims were analysed.…”

Section: Introductionmentioning

confidence: 99%

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The Structure of the Cerebral Cortex in Down's Syndrome – A quantitative analysis –

Colon¹

1972

Neuropediatrics

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“…CROME, COWIE and (GREENFELD 1958). SLATER (1966), demonstrated significant differences between normal and mongoloid brainstem, cerebellum and cerebrum.…”

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

The Structure of the Cerebral Cortex in Down's Syndrome – A quantitative analysis –

Colon¹

1972

Neuropediatrics

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“…Literature for closed bodies see: Bach, 1959aBach, , b, l966,1967aBach, , 1967bHaug, 1967f;DeHoff & Bousquet, 1970;Saltykov, 1958Saltykov, , 1967Scheil, 1931;Schwartz, 1934;Underwood, 1968; for fibres see: Haug, 1967bHaug, , 1968 (6) The measurements of the topological parameters of the neuronal dendrites are a specific problem. Details are given by Colon & Smit, 1970a, 1970b, van der Loos, 1960Schade & Meeter, 1963;Sholl, 1953Sholl, , 1956 Before measuring the tissues they will be prepared as usual according to the dimensions of evaluation. The shrinkage caused by fixation and embedding must be taken into consideration for the measurement.…”

Section: E T H O D Smentioning

confidence: 99%

“…( 3 ) During the last 20 years some almost reliable mathematical procedures have been developed so that it is possible to calculate the spatial lengths and ramification from the values of the flat projection (Colon & Smit, 1970a, 1970bvan der Loos, 1960;Schade L ? Meeter, 1963,;Sholl, 1953Sholl, , 1956Smit & Colon, 1969).…”

Section: (B) the Dendritic Treementioning

confidence: 99%

Stereological methods in the analysis of neuronal parameters in the central nervous system*

Haug

1972

Journal of Microscopy

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SUMMARY The structure of the central nervous system (CNS) is briefly explained. It is compared with the electronic computer and the differences between the two are stated. The methods of measuring this structure and its function are reported. The surface of the cortex as well as the volume of different grey and white matters making up the brain can macroscopically be evaluated on serial slices with the aid of stereological procedures. There is an exponential correlation between volume of the cortex and volume of brain and body in mammals (Fig. 3). The density of neurons and the lengths of their processes can be examined by light microscopy. An improved procedure of counting neurons in the cortex is described. With regard to mammals it is interesting that the densities of neurons in larger brains are lower than in smaller ones. The correlation is negatively exponential. Man and primates have a higher density of cells than the rest of the mammals; their neurons, however, are small. This corresponds to a specialization that can be considered to represent a miniaturization of the neurons (Fig. 4). The topological analysis of dendritic trees is mentioned. The lengths, surfaces and volumes of processes of cells and the amount of synapses can be measured on electron micrographs. The principles and problems of stereology are described by an example of how to measure the myelinated fibres. Some results of the development of these fibres from birth on are reported upon (Fig. 6). In conclusion, some data of the probable dimensions of the human brain are given.

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Some quantitative results on golgi impregnated axons in rat visual cortex using a computer assisted video digitizer

Paldino

Harth

1977

J of Comparative Neurology

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Axonal fiber distributions of pyramidal cells in the visual cortex of the albino rat have been investigated using the rapid Golgi method and modern data collecting techniques. Three dimensional coordinate information was extracted from Golgi-impregnated axonal networks using a computer-assisted video digitizer. Computer programs used this data to generate various statistical distributions. In particular, angular distributions of the initial collateral segments and their endpoints were examined and found to reveal anisotropies. Inspection of the spatial distributions of the endpoints indicated a clustering at two distinct levels with respect to the pyramidal cell from which they originate. Dynamic graphic displays of the three dimensional data have been obtained and presented in the form of computer tracings of various orthogonal projections.

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Quantitative analysis of the cerebral cortex. II. A method for analysing basal dendritic plexuses

Cited by 10 publications

References 12 publications

The Structure of the Cerebral Cortex in Down's Syndrome – A quantitative analysis –

The Structure of the Cerebral Cortex in Down's Syndrome – A quantitative analysis –

Stereological methods in the analysis of neuronal parameters in the central nervous system*

Some quantitative results on golgi impregnated axons in rat visual cortex using a computer assisted video digitizer

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