Quantitative analysis of the high-frequency components of the terminal portion of the body surface QRS in normal subjects and in patients with ventricular tachycardia.

Denes, Pablo; Santarelli, P; Hauser, Robert G.; Uretz, Eugene

doi:10.1161/01.cir.67.5.1129

Cited by 302 publications

(41 citation statements)

References 17 publications

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“…Previous reports suggest that the diagnostic criteria between normal and abnormal SAE values and the late potentials of QRS vary, depending on the equipment used and how the filters are set. However, according to these reports, values determined from a 95% confidence interval of normal subjects [3][4][5][6][7] or determined standard values for comparison of myocardial infarction patients with and without ventricular tachycardia [8][9][10] those criteria varied. The difference in RMS 20 caused by (F) and (B) filter direction was also observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Age and Sex Differences in the P-Wave Signal-Averaged Electrocardiogram in a Japanese Study Population.

et al. 2001

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SUMMARYNormal P wave signal-averaged electrocardiogram (SAE) values were determined in 120 healthy Japanese adults (56 men, 64 women), aged 44.5±10.2 years (mean±SD). The P wave trigger method was used with a Fukuda FDX6500 recorder. We used bipolar Weak positive correlations were observed between fPd (F) and body surface area, fPd (F) and age, fPd (B) and body surface area, fPd (B) and age, fPd (C) and body surface area, and fPd (C) and age. There was no evident correlation, however, between either forward or backward RMS 20 and body surface area or between forward or backward RMS 20 and age. Differences in the normal P wave values between the sexes and age groups were evaluated in this study. (Jpn Heart J 2001; 42: 295-305) Key words: Signal-averaged P wave electrocardiogram, Japanese, Sex, Age ATRIAL late potential studies of P wave recordings by signal-averaged electrocardiography (SAE) have recognized the utility for identifying patients at risk for paroxysmal atrial fibrillation (Paf) during sinus rhythm.1,2) With Paf, filtered P duration (fPd) is long, the last 20-ms root mean square voltage (RMS 20 ) is reported to be low, and the occurrence of Paf can be predicted by such values during sinus rhythm. However, there have been no reports of normal P wave SAE values in Japan.We conducted a study in healthy Japanese subjects to determine the normal value of P waves SAE and to investigate age and sex differences. We expected a From the

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Section: Discussionmentioning

confidence: 99%

Age and Sex Differences in the P-Wave Signal-Averaged Electrocardiogram in a Japanese Study Population.

et al. 2001

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“…Three parameters relating to ventricular late potential, such as filtered QRS duration (fQRS; msec), root mean square voltage (RMS; µV), and low amplitude signal duration (LAS; msec), were analyzed automatically and inspected. 12,13) Data with a noise level greater than 1 µV were excluded from the analysis. Statistical methods: Continuous variables are presented as the mean±SD, and discontinuous variables as the median and range.…”

Section: Methodsmentioning

confidence: 99%

Left Ventricular Diastolic Dysfunction Induced by Cyclophosphamide in Blood Stem Cell Transplantation.

Mori

Yanagi

Maruyama³

et al. 2002

Jpn Heart J

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SUMMARYCardiac complications are major limiting factors regarding the success of high-dose chemotherapy supported by blood stem cell transplantation (BSCT). The cardiotoxicity of cyclophosphamide remains obscure relative to that of anthracyclines. The aim of this study was to estimate noninvasively the cardiotoxicity of cyclophosphamide administered during the pretransplant conditioning of BSCT for patients with various hematological diseases. A total of 27 consecutive patients were divided into two groups depending on the conditioning regimen, ie, group A (n=15) which received cyclophosphamide (median dose of 120 mg/kg; range 100 to 200 mg/kg) and group B (n=12) which did not. Ultrasound cardiograms (UCG) and signal-averaged electrocardiograms (SAECG) were recorded in the two groups both preceding and following the BSCT. There were no statistical intergroup or intragroup differences in left ventricular (LV) dimensions or contractile function. Significant (P<0.01) posttransplant increases in interventricular septal wall thickness and Ap/Ep ratio were noted in group A. Moreover, the filtered QRS duration as estimated by SAECG was prolonged (P<0.05) whereas the summated LV voltage (S V1 +R V5 ) was reduced in the posttransplant period only in group A. These results suggest that early cyclophosphamide cardiotoxicity was characterized by LV diastolic rather than systolic dysfunction. These findings may contribute to acute hemodynamic deterioration observed after cyclophosphamide-containing conditioning chemotherapy. (Jpn Heart J 2002; 43: 249-261)

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“…Random electrical noise can be reduced from its level at the start of the study by the technique of signal averaging by a factor of 1/(n) 1/2 where n is the averaged number of cycles. 3,17 Signal-averaged ECG has allowed the detection of the terminal low amplitude high frequency electrical activity of the QRS complex on the body surface. The ambient noise level is likely to vary from study to study, patient to patient and site to site.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of signal-averaged electrocardiogram in healthy obese women: effects of subcutaneous adipose tissue

et al. 1997

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OBJECTIVE: To determine the correlations between signal-averaged electrocardiography (SAECG) indices and various anthropometric parameters in obese women. SUBJECTS: Twenty-seven healthy obese women (mean age 29.7 AE 9.6 y, mean body mass index 35.2 AE 6.0 kg/m 2 ). MEASUREMENTS: SAECG was performed using a Marquette, MAC 12/15 system. Bidirectional ®ltering, low-pass ®ltering 250 Hz and 25, 40 and 80 Hz high-pass ®lter settings were employed on the same averaged beats. At least 200 beats were averaged to achieve a noise level`1 mV. Body mass index, waist to hip circumference ratio, neck circumference, arm circumference and conicity index were determined for all subjects. Skinfold thicknesses were measured in triceps, biceps, subscapular, supra-iliac and para-umbilical regions. RESULTS: Signi®cant correlations were observed between the root mean square (RMS) voltage of the terminal 40 ms of the ®ltered QRS complex at 25 and 40 Hz and skinfold thicknesses measured at different sites. Signi®cant correlations were obtained between the noise level at 25 and 40 Hz and skinfold thicknesses measured at subscapular, biceps and triceps regions also. The only SAECG parameter correlated signi®cantly with the noise level was the RMS voltage at 25 and 40 Hz high-pass ®lter settings. CONCLUSIONS: In obese women SAECG must be performed with 80 Hz high-pass ®lter setting which eliminates the random noise originating from the subcutaneous adipose tissue. In addition RMS voltage which shows positive linear correlations with the noise level of 25 and 40 Hz high-pass ®lter settings might be inappropriate for the de®nition of abnormal SAECG criteria in obese women.

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Quantitative analysis of the high-frequency components of the terminal portion of the body surface QRS in normal subjects and in patients with ventricular tachycardia.

Cited by 302 publications

References 17 publications

Age and Sex Differences in the P-Wave Signal-Averaged Electrocardiogram in a Japanese Study Population.

Age and Sex Differences in the P-Wave Signal-Averaged Electrocardiogram in a Japanese Study Population.

Left Ventricular Diastolic Dysfunction Induced by Cyclophosphamide in Blood Stem Cell Transplantation.

Evaluation of signal-averaged electrocardiogram in healthy obese women: effects of subcutaneous adipose tissue

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