Quantitative Analysis of the Ultrasonic Vocalization Responses Elicited in Adjuvant-Induced Arthritic Rats for Screening Analgesic Drugs

Naito, Hiroyuki; Inoue, Maki

doi:10.1538/expanim.57.419

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…It should also be also emphasized that ultrasonic 22 kHz vocalizations do not directly signal pain itself [ 320 , 321 , 322 ]. Although the emission of 22 kHz vocalizations was increased during chronic pain (chronic polyarthritis or repeated electrical stimuli) as compared to healthy rats and these calls were suggested to serve as evaluation of analgesic drugs [ 323 , 324 ], 22 kHz vocalizations express an affective component (anxiety) of ongoing or repeated painful experiences, not pain itself, and these calls were sensitive to morphine [ 321 , 325 , 326 , 327 , 328 ]. Pain stimuli can even inhibit ultrasonic calling, which led in the past to a very confusing interpretation [ 328 ].…”

Section: Vocalization As Expression Of Emotional Arousalmentioning

confidence: 99%

Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation

Brudzyński

2021

Brain Sciences

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This review summarizes all reported and suspected functions of ultrasonic vocalizations in infant and adult rats. The review leads to the conclusion that all types of ultrasonic vocalizations subserving all functions are vocal expressions of emotional arousal initiated by the activity of the reticular core of the brainstem. The emotional arousal is dichotomic in nature and is initiated by two opposite-in-function ascending reticular systems that are separate from the cognitive reticular activating system. The mesolimbic cholinergic system initiates the aversive state of anxiety with concomitant emission of 22 kHz calls, while the mesolimbic dopaminergic system initiates the appetitive state of hedonia with concomitant emission of 50 kHz vocalizations. These two mutually exclusive arousal systems prepare the animal for two different behavioral outcomes. The transition from broadband infant isolation calls to the well-structured adult types of vocalizations is explained, and the social importance of adult rat vocal communication is emphasized. The association of 22 kHz and 50 kHz vocalizations with aversive and appetitive states, respectively, was utilized in numerous quantitatively measured preclinical models of physiological, psychological, neurological, neuropsychiatric, and neurodevelopmental investigations. The present review should help in understanding and the interpretation of these models in biomedical research.

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Section: Vocalization As Expression Of Emotional Arousalmentioning

confidence: 99%

Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation

Brudzyński

2021

Brain Sciences

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“…Moreover, it has been demonstrated that the emission of 22-kHz USVs by rats subjected to experimental chronic pain can be attenuated by the administration of drugs that possess clinically relevant analgesic properties, such as morphine and non-steroidal anti-inflammatory drugs (NSAIDs) [ 13 , 74 , 75 ]. Additional studies have shown that novel drugs and natural substances with proposed analgesic activity also are able to modulate the emission of 22-kHz USVs associated with experimental chronic pain in the rat [ 76 , 77 ]. Taken together, these findings envision the evaluation of 22-kHz USVs as a potentially useful tool for the development of novel analgesic therapies.…”

Section: Use Of Rat 22-khz Ultrasonic Vocaliza-tions In Behavioral Nementioning

confidence: 99%

“…In considering these results together, it is important to remark that the studies on 22-kHz USVs and pain described here often differed with regard to the experimental procedures used. Experiments performed in rat models of arthritis have evaluated either the spontaneous emission of 22-kHz USVs, or the vocalization in response to the application of mechanical stimuli [ 13 , 77 - 80 ]. In a similar fashion, studies with the formalin test have evaluated behavioral responses and 22-kHz USVs emission by using different concentrations of the irritant [ 74 , 81 ].…”

Section: Use Of Rat 22-khz Ultrasonic Vocaliza-tions In Behavioral Nementioning

confidence: 99%

Rat Ultrasonic Vocalizations and Behavioral Neuropharmacology: From the Screening of Drugs to the Study of Disease

Simola

2015

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Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivation, and social behavior. Rat USVs are sensitive to the effects of certain classes of psychoactive drugs, suggesting that emission of rat USVs can have relevance not only to neurobiology, but also to neuropharmacology and psychopharmacology. This review summarizes three types of rat USVs, namely 40-kHz USVs emitted by pups, 22-kHz USVs and 50-kHz USVs emitted by young and adult animals, and relevance of these vocalizations to neuropharmacological studies. Attention will be focused on the issues of how rat USVs can be used to evaluate the pharmacological properties of different classes of drugs, and how rat USVs can be combined with other behavioral models used in neuropharmacology. The strengths and limitations of experimental paradigms based on the evaluation of rat USVs will also be discussed.

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Use of spontaneous behaviour measures to assess pain in laboratory rats and mice: How are we progressing?

Whittaker

Howarth

2014

Applied Animal Behaviour Science

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Quantitative Analysis of the Ultrasonic Vocalization Responses Elicited in Adjuvant-Induced Arthritic Rats for Screening Analgesic Drugs

Cited by 3 publications

References 8 publications

Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation

Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation

Rat Ultrasonic Vocalizations and Behavioral Neuropharmacology: From the Screening of Drugs to the Study of Disease

Use of spontaneous behaviour measures to assess pain in laboratory rats and mice: How are we progressing?

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