Quantitative and Morphological Characteristics of the Human Corneal Endothelium in Relation to Age, Gender, and Ethnicity in Cataract Populations of South Asia

Snellingen, Torkel; Rao, Gullapalli N; Shrestha, Junu; Huq, Fazlul; Cheng, H

doi:10.1097/00003226-200101000-00011

Cited by 67 publications

(65 citation statements)

References 14 publications

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“…[15][16][17][18][19][20] When compared with mean ECD values reported for children (3400-4300 cells/mm 2 ) and for elderly eyes (2324-3175 cells/mm 2 ), a clear trend of decreasing mean ECD with advancing age is observed. [9][10][11]15,17,[21][22][23][24][25] Consistent with the majority of other published reports, there was no significant difference in mean ECD based on gender in this study. 5,9,16,17,26,27 With regards to the reliability and repeatability of the NAVIS endothelial analysis system, automated endothelial analysis often fails to correctly identify endothelial cell borders.…”

Section: Discussionsupporting

confidence: 91%

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Patel

McGhee

2008

Eye

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Purpose Despite the importance of a healthy endothelial layer in anterior segment surgery, the possible influence of corneal parameters on endothelial cell density (ECD) has largely been ignored in the young adult eye. This study investigated the possible associations between corneal tomographic parameters and ECD values in young adults. Methods Subjects aged 21-30 years, with normal corneas were recruited. Mean ECD, mean cell area (MCA), coefficient of variation for cell area (COVA), and proportion of hexagonal cells were derived by in vivo confocal microscopy. The Orbscan II system was used to measure corneal parameters including: thickness, horizontal corneal diameter, corneal curvature, anterior and posterior elevation, and eccentricity. Results Sixty-two subjects (42 female, 20 male) were included (mean age 25±3 years). Overall mean ECD was 3169±309 cells/mm 2 with no differences between genders. Mean percentage of hexagonality was 53 ± 5%, male subjects (55%) had a higher percentage of hexagonal cells than female subjects (51%) (P ¼ 0.02). Central corneal thickness (CCT) was 529±43 lm. Central ECD was significantly correlated with CCT (Pearson's r ¼ 0.26, P ¼ 0.04). However, horizontal corneal diameter (r ¼ 0.19, P ¼ 0.14), anterior corneal curvature (r ¼ À0.07, P ¼ 0.6), and posterior corneal curvature (r ¼ À0.07, P ¼ 0.6) were not correlated with ECD or percentage of hexagonality. There was no statistically significant association between anterior chamber depth (3.6±0.3 mm) and ECD (r ¼ 0.15, P ¼ 0.3). Conclusion Corneal thickness is related to ECD in normal young adult eye, with lower ECD values identified in thinner corneas; however, corneal diameter and corneal curvature do not have a significant correlation with ECD.

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Section: Discussionsupporting

confidence: 91%

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Patel

McGhee

2008

Eye

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“…They suggested that this might account for a lower incidence of aphakic bullous keratopathy in Japanese than in Americans. Snellingen and associates 38 proposed that there is a need for further interethnic studies of corneal endothelium to determine whether certain ethnic groups are more prone to surgical trauma.…”

Section: ⅲ Corneamentioning

confidence: 99%

Racial and Ethnic Differences in Ocular Anatomy

Blake

Lai

Edward

2003

International Ophthalmology Clinics

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“…Sadece endotel hücre yoğunluğunda azalma olduğunu göste-ren çalışmaların yanında, DK ve hegzagonalite üze-rinde etkisinin de olduğunu gösteren çalışmalar bulunmaktadır. 10,20 PES'li hasta grubunda glokom varlığının etkisinin değerlendirildiği bir çalışmada endotel hücre yoğunluğunda fark yok iken, glokomu olan PES hastalarında DK ve hegzagonalitede bozulma olduğu gösterilmiştir. 21 PES'nin endotel hücre yoğunluğu, DK ve hegzagonaliteye etkisinin olup olmadığını incelediğimiz bu çalışmada, sadece endotel hücre yoğunluğu üzerinde anlamlı bir etki gösterildi.…”

Section: Discussionunclassified

“…12 Snellingen ve ark.,Hindistan, Bangladeş ve Nepal'de yürüttükleri çalışmada, endotel hücre yoğunluğunda etnik farklılık üzerinde durmuşlardır. 20 Bildirilen endotel hücre yoğunluğu arasındaki geniş dağılım, etnik farklılıkların endotel yapısını etkilediğini düşündürmektedir.…”

Section: 23unclassified

The Characteristics of Cornea Endothelium in Senile Cataract Patients with Pseudoexfoliation Syndrome

İlhan¹,

Türkoğlu²,

Bilgin³

et al. 2015

Turkiye Klinikleri J Ophthalmol

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Quantitative and Morphological Characteristics of the Human Corneal Endothelium in Relation to Age, Gender, and Ethnicity in Cataract Populations of South Asia

Abstract: In a total sample of 1,235 eyes distributed evenly in three cataract patient populations of south Asia, we found statistically significant differences of corneal endothelial cell densities of cell size variability and cell hexagonality between sexes and ethnic groups.

Cited by 67 publications

References 14 publications

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Racial and Ethnic Differences in Ocular Anatomy

The Characteristics of Cornea Endothelium in Senile Cataract Patients with Pseudoexfoliation Syndrome

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