Quantitative and qualitative analysis of edible oils using HRAM MS with an atmospheric pressure chemical ionisation (APCI) source

Potter, Colin M.; Jones, Gareth R.; Barnes, Simon; Jones, Davey L.

doi:10.1016/j.jfca.2020.103760

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Despite the large number of applications historically reported upon the use of IMS as detector for GC, the inclusion of IMS as an additional ion separator within GC–HRMS systems is still in early stages . To the best of our knowledge, only a few applications of GC-APCI coupled with IMS-HRMS have been reported for real-world cases. − In one such application, a comprehensive two-dimensional GC system (GCxGC) coupled with drift-tube IMS (DTIMS)-QTOF was developed for the screening of organic pollutants, enhancing the identification power by using a home-made CCS database of drug-like compounds and pesticides previously built for LC-electrospray-MS applications . The authors stated the lack of CCS data for GC-amenable compounds, which was a limitation on the number of possible hits during the identification step, and claimed the need for expanding the CCS database for a more powerful screening.…”

Section: Introductionmentioning

confidence: 99%

“…In that work, the potential of this technique to separate isomers in each xenobiotic class was emphasized . Recently, the use of a GC-APCI-IMS-QTOF-MS instrument equipped with traveling wave IMS (TWIMS) has been reported to enhance the identification power for the characterization of fatty acid methyl esters in edible oils and long-chain polyunsaturated fatty acids in fish …”

Section: Introductionmentioning

confidence: 99%

“…In that work, the potential of this technique to separate isomers in each xenobiotic class was emphasized. 32 Recently, the use of a GC-APCI-IMS-QTOF-MS instrument equipped with traveling wave IMS (TWIMS) has been reported to enhance the identification power for the characterization of fatty acid methyl esters in edible oils 33 and long-chain polyunsaturated fatty acids in fish. 34 In the present work, we investigate the potential of GC-APCI-IMS-QTOF MS for the screening of organic contaminants in complex-matrix samples and illustrate such potential…”

Section: ■ Introductionmentioning

confidence: 99%

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Benefits of Ion Mobility Separation in GC-APCI-HRMS Screening: From the Construction of a CCS Library to the Application to Real-World Samples

et al. 2022

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The performance of gas chromatography (GC) combined with the improved identification properties of ion mobility separation coupled to high-resolution mass spectrometry (IMS-HRMS) is presented as a promising approach for the monitoring of (semi)volatile compounds in complex matrices. The soft ionization promoted by an atmospheric pressure chemical ionization (APCI) source designed for GC preserves the molecular and/or quasi-molecular ion information enabling a rapid, sensitive, and efficient wide-scope screening. Additionally, ion mobility separation (IMS) separates species of interest from coeluting matrix interferences and/or resolves isomers based on their charge, shape, and size, making IMS-derived collision cross section (CCS) a robust and matrix-independent parameter comparable between instruments. In this way, GC-APCI-IMS-HRMS becomes a powerful approach for both target and suspect screening due to the improvements in (tentative) identifications. In this work, mobility data for 264 relevant multiclass organic pollutants in environmental and food-safety fields were collected by coupling GC-APCI with IMS-HRMS, generating CCS information for molecular ion and/or protonated molecules and some in-source fragments. The identification power of GC-APCI-IMS-HRMS for the studied compounds was assessed in complex-matrix samples, including fish feed extracts, surface waters, and different fruit and vegetable samples.

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