Quantitative and rapid detection of morphine and hydromorphone at the point of care by an automated giant magnetoresistive nanosensor platform

Cortade, Dana L.; Wang, Shan X.

doi:10.1007/s00216-022-04274-2

Cited by 4 publications

(5 citation statements)

References 59 publications

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“…The CV values were calculated to be 2.0, 3.7, and 2.5% at MOP concentrations of 1, 10, and 200 ng/mL, respectively (Figure e). The results in Figure e demonstrate the good intrabatch repeatability of this platform, enabling highly accurate quantification of MOP in urine …”

Section: Resultsmentioning

confidence: 75%

Portable Near-Infrared to Near-Infrared Platform for Homogeneous Quantification of Biomarkers in Complex Biological Samples

Li,

Mai,

Liu

et al. 2024

ACS Nano

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Forster resonance energy transfer (FRET)-based homogeneous immunoassay obviates tedious washing steps and thus is a promising approach for immunoassays. However, a conventional FRET-based homogeneous immunoassay operating in the visible region is not able to overcome the interference of complex biological samples, thus resulting in insufficient detection sensitivity and poor accuracy. Here, we develop a near-infrared (NIR)-to-NIR FRET platform (Ex = 808 nm, Em = 980 nm) that enables background-free high-throughput homogeneous quantification of various biomarkers in complex biological samples. This NIR-to-NIR FRET platform is portable and easy to operate and is mainly composed of a high-performance NIR-to-NIR FRET pair based on lanthanide-doped nanoparticles (LnNPs) and a custommade microplate reader for readout of NIR luminescence signals. We demonstrate that this NIR-to-NIR FRET platform is versatile and robust, capable of realizing highly sensitive and accurate detection of various critical biomarkers, including small molecules (morphine and 1,25-dihydroxyvitamin D), proteins (human chorionic gonadotropin), and viral particles (adenovirus) in unprocessed complex biological samples (urine, whole blood, and feces) within 5−10 min. We expect this NIR-to-NIR FRET platform to provide low-cost healthcare for populations living in resource-limited areas and be widely used in many other fields, such as food safety and environmental monitoring.

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Section: Resultsmentioning

confidence: 75%

Portable Near-Infrared to Near-Infrared Platform for Homogeneous Quantification of Biomarkers in Complex Biological Samples

Li,

Mai,

Liu

et al. 2024

ACS Nano

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“…Cortade and coworkers [75] detailed their work on developing a giant magnetoresistive nanosensor array (GMR) for the dual-use detection of morphine and hydromorphone in saliva, blood, and plasma. The fabricated array was comprised of an array of 80 independent sensors on a square 5 × 5 mm chip that was bound to a printed circuit board with wire.…”

Section: Biosensors Detection 21 Bisosensors Detection Of Pharmaceuti...mentioning

confidence: 99%

“…The resultant device was not only easy to manufacture but also multiplexable, supported the point-of-care quantification needs over a wide range of concentrations, and allowed for detecting the analytes in saliva, whole blood, and plasma. In addition, less than 200 mL of sample is needed for analysis, which is essential because a limiting factor for accurate analysis may be sample size [75]. Biological samples are essential targets for ever-developing screening tools, which can help researchers gain an understanding of the metabolic impact of opioid use and allow for greater variation in the types of samples that can be tested to determine opioid concentrations or to confirm drug presence.…”

Section: Biosensors Detection 21 Bisosensors Detection Of Pharmaceuti...mentioning

confidence: 99%

Electrochemical Sensors, Biosensors, and Optical Sensors for the Detection of Opioids and Their Analogs: Pharmaceutical, Clinical, and Forensic Applications

Fakayode,

Brady,

Grant

et al. 2024

Chemosensors

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Pharmaceutical opioids are intravenously or orally administered analgesics. While they are effective in relieving chronic and acute pain, their narrow window of therapeutic use contributes to the high occurrence of abuse. The associated abuse of this family of drugs can be correlated to the increase in dependency, overdose, and death of users. The negative effects of opioids extend beyond the physical and psychological effects experienced by the user to their unregulated synthesis and sale, which contribute to socioeconomic challenges and are a biproduct of this global public health epidemic. From clinical to point-of-care applications, the detection and real-time monitoring of this family of drug is critical in the fight to decrease abuse and improve use in clinical settings. Chromatographic separations and chromatography–mass spectrometry are traditional methods of opioid analyses, but the high cost, long analysis time, and absence of portability highlight the need for the development of fast, in situ, point-of-care analysis, or of community drug monitoring services. This review highlights recent electrochemical and optical (FTIR, Raman, colorimetric, and fluorescent) advances and biosensors for pharmaceutical and illicit opioid analysis. Specifically, an emphasis is placed on the detection of opioids and their metabolites in biological samples and in vitro cellular assays for clinical diagnosis and forensic applications. The challenges and prospects of the role of electrochemical sensors, biosensors, and optical sensors for opioid analysis in promoting clinical diagnosis, forensic study, point-of-care, and community drug monitoring services to reduce harm are also provided.

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“…Giant magnetoresistance (GMR) bead-based biosensors utilize the changes in resistance resulting from the binding events between the target biomarker and the bead-bound capture molecule. The beads are functionalized with capture molecules, and when the target biomarker binds, it induces changes in the magnetic field around the GMR sensor, leading to changes in resistance [154]. The resistance change is then measured and correlated with the concentration of the target biomarker.…”

Section: Magnetic Biosensorsmentioning

confidence: 99%

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Cheng,

Yang,

Wang

et al. 2024

Sensors

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Demand is strong for sensitive, reliable, and cost-effective diagnostic tools for cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising diagnostic platforms based on wide-ranging cancer biomarkers owing to the versatility, high sensitivity, and flexibility to perform the multiplexing of beads. This comprehensive review highlights recent trends and innovations in the development of bead-based biosensors for cancer-biomarker detection. We introduce various types of bead-based biosensors such as optical, electrochemical, and magnetic biosensors, along with their respective advantages and limitations. Moreover, the review summarizes the latest advancements, including fabrication techniques, signal-amplification strategies, and integration with microfluidics and nanotechnology. Additionally, the challenges and future perspectives in the field of bead-based biosensors for cancer-biomarker detection are discussed. Understanding these innovations in bead-based biosensors can greatly contribute to improvements in cancer diagnostics, thereby facilitating early detection and personalized treatments.

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Quantitative and rapid detection of morphine and hydromorphone at the point of care by an automated giant magnetoresistive nanosensor platform

Cited by 4 publications

References 59 publications

Portable Near-Infrared to Near-Infrared Platform for Homogeneous Quantification of Biomarkers in Complex Biological Samples

Portable Near-Infrared to Near-Infrared Platform for Homogeneous Quantification of Biomarkers in Complex Biological Samples

Electrochemical Sensors, Biosensors, and Optical Sensors for the Detection of Opioids and Their Analogs: Pharmaceutical, Clinical, and Forensic Applications

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

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