Quantitative and structural characteristics of mitochondrial DNA in varicose veins

Сметанина, М. А.; Oscorbin, Igor P.; Shadrina, Alexandra S.; Sevost'ianova, Kseniya; Korolenya, V. A.; Gavrilov, Konstantin A.; Шевела, А. И.; Shirshova, A.N.; Oskina, N. А.; Золотухин, И. А.; Филипенко, М. Л.

doi:10.1016/j.vph.2022.107021

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…Moreover, a lower percentage of mtDNA without deletions and a decrease in the relative mitochondrial membrane potential in ECs were observed in VV. These results demonstrate the involvement of mtDNA in the pathogenesis of VV and suggest a possible reduction in mitochondrial function in this disease [137].…”

Section: Mtdna In Varicose Veinssupporting

confidence: 59%

Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

Gwozdzinski,

Pieniazek,

Gwozdzinski

2024

IJMS

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One of the early symptoms of chronic venous disease (CVD) is varicose veins (VV) of the lower limbs. There are many etiological environmental factors influencing the development of chronic venous insufficiency (CVI), although genetic factors and family history of the disease play a key role. All these factors induce changes in the hemodynamic in the venous system of the lower limbs leading to blood stasis, hypoxia, inflammation, oxidative stress, proteolytic activity of matrix metalloproteinases (MMPs), changes in microcirculation and, consequently, the remodeling of the venous wall. The aim of this review is to present current knowledge on CVD, including the pathophysiology and mechanisms related to vein wall remodeling. Particular emphasis has been placed on describing the role of inflammation and oxidative stress and the involvement of extracellular hemoglobin as pathogenetic factors of VV. Additionally, active substances used in the treatment of VV were discussed.

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Section: Mtdna In Varicose Veinssupporting

confidence: 59%

Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

Gwozdzinski,

Pieniazek,

Gwozdzinski

2024

IJMS

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Vicious Circle With Venous Hypertension, Irregular Flow, Pathological Venous Wall Remodeling, and Valve Destruction in Chronic Venous Disease: A Review

Nadasy,

Patai,

Molnar

et al. 2024

Angiology

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Substantial advances occurred in phlebological practice in the last two decades. With the use of modern diagnostic equipment, the patients’ venous hemodynamics can be examined in detail in everyday practice. Application of venous segments for arterial bypasses motivated studies on the effect of hemodynamic load on the venous wall. New animal models have been developed to study hemodynamic effects on the venous system. In vivo and in vitro studies revealed cellular phase transitions of venous endothelial, smooth muscle, and fibroblastic cells and changes in connective tissue composition, under hemodynamic load and at different locations of the chronically diseased venous system. This review is an attempt to integrate our knowledge from epidemiology, paleoanthropology and anthropology, clinical and experimental hemodynamic studies, histology, cell physiology, cell pathology, and molecular biology on the complex pathomechanism of this frequent disease. Our conclusion is that the disease is initiated by limited genetic adaptation of mankind not to bipedalism but to bipedalism in the unmoving standing or sitting position. In the course of the disease several pathologic vicious circles emerge, sustained venous hypertension inducing cellular phase transitions, chronic wall inflammation, apoptosis of cells, pathologic dilation, and valvular damage which, in turn, further aggravate the venous hypertension.

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Varicose vein disease in the context of insulin resistance

Korolenya,

Filipenko,

Smetanina

2024

Vessel Plus

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The prevalence of insulin resistance (IR) is growing every year, which determines the risks of developing type 2 diabetes and cardiovascular diseases. Currently, IR is not recognized as a risk factor for the development of varicose veins (VVs), but the connection between the two is tacitly obvious because obesity and diabetes are risk factors for VVs. In this review, we have attempted to highlight the common nature of these two conditions in the context of mitochondrial dysfunction, inflammation, endothelial dysfunction, and tissue hypertrophy, and spotlight the role of IR in the development of VVs. We conclude that IR can contribute to the appearance of VVs.

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Quantitative and structural characteristics of mitochondrial DNA in varicose veins

Cited by 4 publications

References 38 publications

Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

Vicious Circle With Venous Hypertension, Irregular Flow, Pathological Venous Wall Remodeling, and Valve Destruction in Chronic Venous Disease: A Review

Varicose vein disease in the context of insulin resistance

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