Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis

Graham, Andrea L.; Taylor, Matthew D.; Goff, Laëtitia Le; Lamb, Tracey J.; Magennis, Marisa; Allen, Judith E.

doi:10.1016/j.micinf.2004.12.019

Cited by 29 publications

(33 citation statements)

References 48 publications

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“…Mice were euthanized on day 4. Mice were infected subcutaneously with 25 Litomososides sigmodontis L3, 20 and analysis of pleural cavity cells was performed 12 days after infection. For Schisotosoma mansoni infection, mice were infected percutaneously on the abdominal surface with 25 to 35 cercariae of a Puerto Rican strain (Biomedical Research Institute, Rockville, MD), and analysis of liver leukocytes was performed 8 weeks after infection.…”

Section: C57bl/6 Stat6mentioning

confidence: 99%

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

Gundra

Girgis

Rückerl

et al. 2014

Blood

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308

270

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Section: C57bl/6 Stat6mentioning

confidence: 99%

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

Gundra

Girgis

Rückerl

et al. 2014

Blood

Self Cite

308

270

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“…BALB/c, BALB/k, and BALB/b mice are transiently permissive, with BALB/c mice sustaining the longest period of microfilaremia (195). Female BALB/c mice are more susceptible to infection than male BALB/c mice, as measured by both adult worm burden and microfilaremia, but in other strains of mice, males are more susceptible (195,196). Between 30 and 100% of infected BALB/c mice become microfilaremic, depending on the inoculation protocol (184,197).…”

Section: (V) Vaccine Studies (A) Protection Against Microfilaremiamentioning

confidence: 99%

A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

et al. 2013

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SUMMARY Filarial worms cause highly morbid diseases such as elephantiasis and river blindness. Since the 1940s, researchers have conducted vaccine trials in 27 different animal models of filariasis. Although no vaccine trial in a permissive model of filariasis has provided sterilizing immunity, great strides have been made toward developing vaccines that could block transmission, decrease pathological sequelae, or decrease susceptibility to infection. In this review, we have organized, to the best of our ability, all published filaria vaccine trials and reviewed them in the context of the animal models used. Additionally, we provide information on the life cycle, disease phenotype, concomitant immunity, and natural immunity during primary and secondary infections for 24 different filaria models.

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“…Our study focused on the impact of acute L. sigmodontis infection on the humoral response using the semipermissive C57BL/ 6 mouse strain (61). Preliminary experiments show that L. sigmodontis infection interfered with Th cell proliferation and humoral response to TD but not TI model Ags also in the fully permissive BALB/c mouse strain, which allows the analysis of effects induced by chronic L. sigmodontis infection (W. Hartmann and I. Haben, unpublished observations).…”

Section: Ot-ii T Cells and Thus Reduced Dilution Of Foxp3mentioning

confidence: 99%

Pathogenic Nematodes Suppress Humoral Responses to Third-Party Antigens In Vivo by IL-10–Mediated Interference with Th Cell Function

Hartmann

Haben

Fleischer

et al. 2011

The Journal of Immunology

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One third of the human population is infected with helminth parasites. To promote their longevity and to limit pathology, helminths have developed several strategies to suppress the immune response of their host. As this immune suppression also acts on unrelated third-party Ags, a preexisting helminth infection may interfere with vaccination efficacy. In this study, we show that natural infection with Litomosoides sigmodontis suppressed the humoral response to thymus-dependent but not to thymus-independent model Ags in C57BL/6 mice. Thereby, we provide evidence that reduced humoral responses were mediated by interference with Th cell function rather than by direct suppression of B cells in L. sigmodontis-infected mice. We directly demonstrate suppression of Ag-specific proliferation in OVA-specific Th cells after adoptive transfer into L. sigmodontis-infected mice that led to equally reduced production of OVA-specific IgG. Transferred Th cells displayed increased frequencies of Foxp3+ after in vivo stimulation within infected but not within naive mice. Helminth-mediated suppression was induced by established L. sigmodontis infections but was completely independent of the individual worm burden. Using DEREG mice, we rule out a central role for host-derived regulatory T cells in the suppression of transferred Th cell proliferation. In contrast, we show that L. sigmodontis-induced, host-derived IL-10 mediated Foxp3 induction in transferred Th cells and significantly contributed to the observed Th cell hypoproliferation within infected mice.

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Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis

Cited by 29 publications

References 48 publications

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

Pathogenic Nematodes Suppress Humoral Responses to Third-Party Antigens In Vivo by IL-10–Mediated Interference with Th Cell Function

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