Quantitative approaches of nanofibers organization for biomedical patterned nanofibrous scaffold by image analysis

Hosseini, Neda Shah; Simon, Bertrand; Messaoud, Tahani; Khenoussi, Nabyl; Schacher, Laurence; Adolphe, Dominique

doi:10.1002/jbm.a.36485

Cited by 10 publications

(5 citation statements)

References 36 publications

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“…The properties of NFs produced by electrospinning technique are widely dependent on different parameters classified to three categories of solution, process, and ambient parameters. Thus, combination of variable parameters with different levels through a design of experiments (DOEs) can be beneficial to find optimized and most influential parameters in order to obtain the desirable morphology and organization of NFs . In this study, the experimental design was performed based on Taguchi's mixed‐level parameter design (L16).…”

Section: Methodsmentioning

confidence: 99%

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Jafari

Salekdeh

Solouk

et al. 2019

Polymers for Advanced Techs

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Nanostructured biomaterials have great potential in the field of biomedical engineering. Efforts for treatment of cardiovascular diseases focused on introducing vascular substitutes that are nonthrombogenic and have long-term patency, but still there is not any perfect replacement for clinical use. In this study, nanostructure tubes of a commonly known biocompatible polymer, polyethylene terephthalate (PET), were prepared via electrospinning process using small diameter mandrel as a collector with two different speeds. The nanofibers (NFs) morphologies' physical and mechanical properties were investigated according to scanning electron microscope (SEM), water contact angle (WCA), porosity measurement, differential scanning calorimetry (DSC), and tensile test. Finer NFs, more percentage of crystallinity, and superior mechanical properties were observed for samples prepared by higher speed mandrel. Since both samples stimulated platelet adhesion and activation, further surface modification with sodium nitrate as nitric oxide (NO) donor was done using two different approaches: dip-coating and electrospraying. The modified NFs were evaluated via SEM, WCA, tensile test, platelets, and cell adhesion. The results showed more hydrophilicity, reduction in platelet adhesion, and improved blood compatibility for eNO-HS (electrosprayed NO for higher collector speed) compared with other samples implying the promising potential of this fabrication and modification technique for improving PET-based cardiovascular substitutes.

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Section: Methodsmentioning

confidence: 99%

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Jafari

Salekdeh

Solouk

et al. 2019

Polymers for Advanced Techs

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“…By combining the gap technique (the electrospun collector composed of two stapler-shaped metal frames that are placed next to each other with an air gap between them) and 3D printing methods, highly oriented and random zones of electrospun nanofibers were produced onto a static 3D collector made by a 3D printing technique, achieving accurate control of the electrospun nanofiber structure using the patterned collectors. [80,83] The geometry of the collectors can also influence the morphology, porosity, thermal properties, and mechanical properties of electrospun scaffolds. Electrospun scaffolds with custom-tailored topography were fabricated by 3D-printed collectors with different essential geometrical elements, and the structure of electrospun scaffolds can be optimized depending on their demands.…”

Section: Fabrication Of Electrospun Scaffolds On 3d-printed Collector...mentioning

confidence: 99%

Combination of 3D Printing and Electrospinning Techniques for Biofabrication

Fazal

Wang

Radacsi

2022

Adv Materials Technologies

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This review presents the different combination methods of 3D printing and electrospinning processes and discusses the advantages of each method. Also, the applications of products of the hybrid process in the biomedical field, including tissue engineering and regenerative medicine, are thoroughly discussed. 3D printing and electrospinning are separate approaches for generating structured materials in a variety of biomedical applications. However, some shortfalls, such as the low resolution of 3D printing and uncontrollable shape of electrospun products, limits their application performances. Therefore, new ideas that combine 3D printing and electrospinning methods are proposed to give full play to their strengths and mitigate their weaknesses, which provide an effective and powerful platform for fabricating novel structural materials. Finally, a future vision regarding challenges and perspectives in the combination of 3D printing and electrospinning techniques is proposed.

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“…By having a 3D model, the scaffolds can imitate eye structures such as the cornea. These scaffolds also allow the entry of collagen into the ECM. − On the other hand braided/woven/knitted yarn networks, aligned nanofiber yarns, and composites made of fibrous yarns and hydrogels displayed potential in stimulating the differentiation of MSCs to anisotropic soft tissues. For heart valve engineering it can be possible to produce scaffolds using woven fabric as well as a bioactive hydrogel .…”

Section: Nanofiber Scaffolds For Biomedical Applicationsmentioning

confidence: 99%

Recent Advances in Designing Fibrous Biomaterials for the Domain of Biomedical, Clinical, and Environmental Applications

Mamidi

García

Martínez

et al. 2022

ACS Biomater. Sci. Eng.

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Unique properties and potential applications of nanofibers have emerged as innovative approaches and opportunities in the biomedical, healthcare, environmental, and biosensor fields. Electrospinning and centrifugal spinning strategies have gained considerable attention among all kinds of strategies to produce nanofibers. These techniques produce nanofibers with high porosity and surface area, adequate pore architecture, and diverse chemical compositions. The extraordinary characteristics of nanofibers have unveiled new gates in nanomedicine to establish innovative fiber-based formulations for biomedical use, healthcare, and a wide range of other applications. The present review aims to provide a comprehensive overview of nanofibers and their broad range of applications, including drug delivery, biomedical scaffolds, tissue/bone-tissue engineering, dental applications, and environmental remediation in a single place. The review begins with a brief introduction followed by potential applications of nanofibers. Finally, the future perspectives and current challenges of nanofibers are demonstrated. This review will help researchers to engineer more efficient multifunctional nanofibers with improved characteristics for their effective use in broad areas. We strongly believe this review is a reader’s delight and will help in dealing with the fundamental principles and applications of nanofiber-based scaffolds. This review will assist students and a broad range of scientific communities to understand the significance of nanofibers in several domains of nanotechnology, nanomedicine, biotechnology, and environmental remediation, which will set a benchmark for further research.

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Quantitative approaches of nanofibers organization for biomedical patterned nanofibrous scaffold by image analysis

Cited by 10 publications

References 36 publications

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Combination of 3D Printing and Electrospinning Techniques for Biofabrication

Recent Advances in Designing Fibrous Biomaterials for the Domain of Biomedical, Clinical, and Environmental Applications

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