2008
DOI: 10.1097/01.anes.0000299433.25179.70
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Quantitative Architecture of the Brachial Plexus and Surrounding Compartments, and Their Possible Significance for Plexus Blocks

Abstract: Marked differences in neural architecture and size of surrounding adipose tissue compartments are demonstrated between proximal and distal parts of the brachial plexus. These differences may explain why some injections within the epineurium do not result in neural injury and affect onset times of BP blocks.

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Cited by 133 publications
(106 citation statements)
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“…Cadaver studies indicate that the amount of connective tissue within the epineurium of the brachial plexus is least at proximal sites (55% for interscalene and 52% for supraclavicular) compared with distal sites (66% for subcoracoid) [3]. However, even at proximal brachial plexus block sites, the majority of the intraneural space typically consists of connective tissue.…”
Section: ó 2011 the Authorsmentioning
confidence: 99%
“…Cadaver studies indicate that the amount of connective tissue within the epineurium of the brachial plexus is least at proximal sites (55% for interscalene and 52% for supraclavicular) compared with distal sites (66% for subcoracoid) [3]. However, even at proximal brachial plexus block sites, the majority of the intraneural space typically consists of connective tissue.…”
Section: ó 2011 the Authorsmentioning
confidence: 99%
“…When nerves are impaled, the needle may pass harmlessly into or through connective tissue, which constitutes up to 70% of a nerve's cross-sectional area. 28 However, if the fascicle is penetrated, neurons are exposed to local anesthetics that can cause time-and concentration-dependent injury. Vasoconstrictors play a role by limiting local anesthetic clearance and thereby enhancing the time-dependent component of injury.…”
Section: Pathophysiology Of Peripheral Nerve Injurymentioning
confidence: 99%
“…This explains why a simple penetration of the suprascapular nerve epineurium does not necessarily lead to nerve damage. 37,38 Local anesthetic infusion in the perineurium is associated with high injection pressure, subsequent fascicular lesion and neurologic injury, but the infusion within the epineurium occurs at low pressure, with motor function returning to normal. 39 Therefore, intraneural infusion outside the perineurium does not invariably lead to neurological damage.…”
Section: Peripheral Nerve Injurymentioning
confidence: 99%