Quantitative Aspiration During Sleep in Normal Subjects

Gleeson, Kevin; Eggli, Douglas F.; Maxwell, Steven L.

doi:10.1378/chest.111.5.1266

Cited by 386 publications

(275 citation statements)

References 9 publications

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“…These dynamic changes might be relevant for our understanding of pathogenesis in pulmonary health and disease. In the lung, microaspiration commonly is a repetitive phenomenon (12). As discussed previously, this might explain the frequent observation of oral taxa such as Prevotella and Veillonella in the lower airway microbiome.…”

Section: State Of the Art S22mentioning

confidence: 85%

“…However, this has not been a consistent finding in all studies, which suggests substantial technical heterogeneity (8). In contrast, it is well known that microaspiration is a common phenomenon among healthy persons, and that it is exacerbated in several respiratory disease states (12)(13)(14). The finding of low bacterial burden in the normal lung supports the view that although the healthy lung has the ability to clear microaspirated microbes, a residual microbiota coexists in the lung mucosa.…”

mentioning

confidence: 89%

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A Brave New World: The Lung Microbiota in an Era of Change

Segal

Blaser

2014

Annals ATS

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Section: State Of the Art S22mentioning

confidence: 85%

mentioning

confidence: 89%

A Brave New World: The Lung Microbiota in an Era of Change

Segal

Blaser

2014

Annals ATS

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“…One is from local production and the other is from physiological microaspiration [3][4][5][6]. Nandapalan in 1995 published two works on this-one on laryngectomized patients and the other on tracheotomized patients.…”

Section: Discussionmentioning

confidence: 99%

“…The amylase in the lungs of humans under normal conditions probably has two components-one is from local production and the other from physiological micro aspiration [1][2][3][4][5][6]. Takano in 1938 demonstrated in rabbits that the blood of theirs right heart had major amylase concentration than the left chambers, which the plausible explanation is the passage of amylase from lung circulation to general circulation 1 .…”

Section: Introductionmentioning

confidence: 99%

Activity of Alpha Amylase in Tracheobronchial Secretions of Patients without Morbid Salivary Aspiration

2017

MOJBM

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Background:The normal values of alpha-amylase in humans is unknown.Objective: To determine the normal values of alpha-amylase activity in humans. Material and methods:From October 2009 to June 2011 we studied 111 patients referenced to thoracic service to be submitted to bronchoscopy. The patients were positioned in supine position, performed local antisepsis and anesthetized with 2% lidocaine . Thereafter we introduced a needle into catheter by puncturing the cricothyroid membrane using a 14G cateter. Finally we introduced ten milliliters of saline and immediately aspirated with the maximum power of the vacuum system. The samples were sent for α-amylase activity determination by CNPG method. Results:The activity of α-amylase of tracheal aspirate ranged from 24 to 10.000 IU/l), and a mean 1914IU/L. The levels had no statistical differences according age, sex, race, smoking history and the lung diseases.Conclusion: we could define the probably physiologic levels of amylase activity in humans beings.

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“…Normal individuals aspirate small volumes of oral secretions during sleep [27] without sequelae, and this occult aspiration occurs more often in the setting of depressed consciousness [28]. Proximal GER creates the potential for aspiration, the outcome of which varies with the chronicity of the events and the volume and nature of the aspirate.…”

Section: Mechanisms Of Respiratory Disease In Gerdmentioning

confidence: 99%

Gastro-oesophageal reflux disease and non-asthma lung disease

Morehead¹

2009

Eur Respir Rev

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Gastro-oesophageal reflux disease (GERD) is a common disorder in Western countries, and its relationship to airways disorders (e.g. asthma) has been well established. Lung diseases other than asthma have also been associated with GERD, but the nature and scope of this relationship has not been fully defined. Diseases that have been associated with GERD include bronchiolitis syndromes, idiopathic pulmonary fibrosis, scleroderma and nontubercular mycobacterial infection.Diagnostic evaluation centres upon proving both reflux and pulmonary aspiration, which may be accomplished in some cases by lung biopsy. However, in many cases a compatible clinical and radiographic picture coupled with proof of proximal reflux by combined oesophageal probe testing may suffice for a provisional diagnosis and allow institution of anti-reflux measures.Proton-pump inhibitors are the medications of choice for GERD; other interventions shown to reduce reflux are weight loss, elevation of the head of the bed and avoidance of recumbency after meals. However, acid suppression therapy does not address non-acid reflux that may be important in disease pathogenesis in select patients, and lifestyle modifications often fail.Laparoscopic fundoplication is the procedure of choice for medically refractory GERD with excellent short-term results with respect to respiratory symptoms associated with GERD; however, long-term studies document a significant percentage of patients requiring ongoing acid suppression therapy.

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Quantitative Aspiration During Sleep in Normal Subjects

Cited by 386 publications

References 9 publications

A Brave New World: The Lung Microbiota in an Era of Change

A Brave New World: The Lung Microbiota in an Era of Change

Activity of Alpha Amylase in Tracheobronchial Secretions of Patients without Morbid Salivary Aspiration

Gastro-oesophageal reflux disease and non-asthma lung disease

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