Quantitative Assessment of Atrial Regional Function Using Motion Estimation Computed Tomography

Ashikaga, Hiroshi; Cammin, J.; Tang, Qinghua; Knudsen, Karly; Inoue, Yuko; Fishman, Elliot K.; Taguchi, Katsuyuki

doi:10.1097/rct.0000000000000108

Cited by 7 publications

(9 citation statements)

References 9 publications

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“…Motion estimation error throughout the cardiac cycle for all the animals was 0.76 ± 0.43 mm (95 % CI 0.68-0.84 mm). This suggests that image-based motion estimation might allow accurate assessment of complex three-dimensional regional atrial function in vivo with high spatiotemporal resolution [59].…”

Section: Left Atrial Functional Assessmentmentioning

confidence: 99%

State-of-the-Art CT Imaging of the Left Atrium

Karády

Whitaker²,

Rajani³

et al. 2016

Curr Radiol Rep

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Purpose of the Review Cardiac computed tomography (CT) angiography with its high spatial and temporal resolution is a robust anatomical imaging tool. Beyond coronary artery examination in suspected coronary artery disease, cardiac CT is a helpful modality to depict cardiac morphology in surgical and percutaneous structural interventions planning. Conditions related to the left atrium are diverse; therefore, the importance of CT imaging is becoming more frequent. Recent Findings Latest technological advancements allow for low radiation dose image acquisition along with improved image quality detailed visualization of the left atrium during interventional procedure planning. In addition, left atrial imaging provides additional information regarding stroke risk, cardiovascular outcomes, congestive heart failure, and arrhythmia mechanisms. Therefore, the left atrium has been proposed as a barometer of cardiac function and cardiovascular risk.Summary Cardiac CT has become an indispensable tool in the electrophysiology laboratory in the guidance of complex procedures, including trans-catheter pulmonary vein isolation in the treatment of drug-refractory atrial fibrillation. The detailed visualization of left atrial morphology and pulmonary vein anatomy is frequently helpful in achieving therapeutic success and avoiding complications.

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Section: Left Atrial Functional Assessmentmentioning

confidence: 99%

State-of-the-Art CT Imaging of the Left Atrium

Karády

Whitaker²,

Rajani³

et al. 2016

Curr Radiol Rep

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“…Custom programs in MATLAB (MathWorks Inc.) were used to perform surface rendering with triangular mesh from the segmented DICOM images, and the relative change in the area from the ventricular end diastole (0% R-R) to other phases of interest, called area change ratio (%), was calculated for each mesh triangle at each cardiac phase to assess 2-D surface deformation over time. 12 Area change ratio is a 2-D equivalent of a strain, often referred to as area strain, and is clinically used to measure regional myocardial function in 3-D speckle-tracking echocardiogram. 13 Compared with traditional, one-dimensional indices of myocardial deformation, area change ratio is more sensitive, has a higher signal-to-noise ratio, and is highly reproducible.…”

Section: Calculation Of Laa Regional Functionmentioning

confidence: 99%

“…Recently, we have validated a novel image-based motion-estimation computed tomography (CT) (iME) 11 to quantify atrial regional function. 12 iME is similar to three-dimensional (3-D) speckle-tracking imaging that takes advantage of both the non-invasive nature and the high spatial resolution of CT images. The aim of the study was to examine the association between the LAA regional function and the history of stroke or TIA in patients with a history of AF using iME.…”

Section: Introductionmentioning

confidence: 99%

Regional function analysis of left atrial appendage using motion estimation CT and risk of stroke in patients with atrial fibrillation

Al-Issa

Inoue

Cammin

et al. 2015

Eur Heart J Cardiovasc Imaging

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“…iME1 estimates a nonrigid deformation of the heart using an intensity‐based optimization method by minimizing a sum of squared weighted differences with spatial and temporal roughness penalty terms. The iME1 has been evaluated in clinical and swine studies with images acquired at the standard dose over the entire heartbeat. In this study, we modified iME1 to overcome challenges in protocol (a), which we call iME2, and assessed the performance of both iME1 and iME2 using clinical data.…”

Section: Introductionmentioning

confidence: 99%

Motion estimation for cardiac functional analysis using two x‐ray computed tomography scans

et al. 2017

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Purpose This work concerns computed tomography (CT)-based cardiac functional analysis (CFA) with a reduced radiation dose. As CT-CFA requires images over the entire heartbeat, the scans are often performed at 10–20% of the tube current settings that are typically used for coronary CT angiography. A large image noise then degrades the accuracy of motion estimation. Moreover, even if the scan was performed during the sinus rhythm, the cardiac motion observed in CT images may not be cyclic with patients with atrial fibrillation. In this study, we propose to use two CT scan data, one for CT angiography at a quiescent phase at a standard dose and the other for CFA over the entire heart beat at a lower dose. Methods We have made the following four modifications to an image-based cardiac motion estimation method we have previously developed for a full-dose retrospectively-gated coronary CT angiography: (1) A full-dose prospectively-gated coronary CT angiography image acquired at the least motion phase was used as the reference image; (2) a three-dimensional median filter was applied to lower-dose retrospectively-gated cardiac images acquired at 20 phases over one heartbeat in order to reduce image noise; (3) the strength of the temporal regularization term was made adaptive; and (4) a one-dimensional temporal filter was applied to the estimated motion vector field in order to decrease jaggy motion patterns. We call the conventional method iME1 and the proposed method iME2 in this paper. Five observers assessed the accuracy of the estimated motion vector field of iME2 and iME1 using a 4-point scale. The observers repeated the assessment with data presented in a new random order one week after the first assessment session. Results The study confirmed that the proposed iME2 was robust against the mismatch of noise levels, contrast enhancement levels, and shapes of the chambers. There was a statistically significant difference between iME2 and iME1 (accuracy score, 2.08±0.81 versus 2.77±0.98, P<0.01) and the improvement by the score of +0.69 seemed clinically relevant. Inter-observer concordance was good: The inter-class correlation coefficient was 0.63 and Kendall’s rank correlation coefficients were in the range of 0.41–0.67 (P<0.01) respectively. Intra-observer reproducibility between sessions was good with the inter-class correlation coefficient of 0.76. Conclusion We have proposed iME2 method for CT-CFA with two CT scans. The observer study verified the robustness and accuracy of iME2 method and its improved performance over iME1 method

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Quantitative Assessment of Atrial Regional Function Using Motion Estimation Computed Tomography

Cited by 7 publications

References 9 publications

State-of-the-Art CT Imaging of the Left Atrium

State-of-the-Art CT Imaging of the Left Atrium

Regional function analysis of left atrial appendage using motion estimation CT and risk of stroke in patients with atrial fibrillation

Motion estimation for cardiac functional analysis using two x‐ray computed tomography scans

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