Quantitative assessment of bradykinesia in patients with parkinson's disease

Dunnewold, R.; Jacobi, Catharina E.; Hilten, J.J. van

doi:10.1016/s0165-0270(97)02254-1

Cited by 62 publications

(35 citation statements)

References 10 publications

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“…A variety of attempts have been made for the objective, quantitative, and simple assessment of motor disability in PD (3)(4)(5). The UPDRS, widely utilized, is useful for semiquantitative clinical assessment of the entire performance and not simply the motor performance, but it requires interpretation by physicians and is thus not a fully objective scale.…”

Section: Discussionmentioning

confidence: 99%

Lifecorder: A New Device for the Long-term Monitoring of Motor Activities for Parkinson's Disease

et al. 2004

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Objective To quantitatively evaluate motor activity, its fluctuations, and drug effects in patients with Parkinson's disease (PD), the Lifecorder ® , a new monitoring device, was attached to a group of patients for several weeks. This enabled the continuous recording of motor activity in ten scaled magnitudes at two-minute intervals for 6 weeks.Patients and Methods Thirteen patients with PD who required dopamine receptor agonist therapy were monitored with Lifecorder, and seven healthy subjects served as the control group. The data obtained with this device correlated well with the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn-Yahr grading. The dose of cabergoline, a D2-receptor agonist, was increased every 2 weeks, until optimum improvement was achieved.Results By adding cabergoline, the mean UPDRS improved from 40.5 to 28.4, which was significant. In parallel, the mean daily walking count (WC) also increased from 2,459 to 3,315 steps (p<0.01) and movement-related calorie consumption (

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Section: Discussionmentioning

confidence: 99%

Lifecorder: A New Device for the Long-term Monitoring of Motor Activities for Parkinson's Disease

et al. 2004

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“…For these reasons, an objective monitor performing both long-term and ambulatory measurements of symptom severity is needed. Ambulatory monitoring of PD, studying tremor, bradykinesia, and hypokinesia with kinematic sensors has been widely studied over the past decades [2]- [5]. However, these studies usually only consider a few basic aspects of the complex symptomatology.…”

Section: Ambulatory Monitoring Of Activities and Motormentioning

confidence: 99%

Ambulatory Monitoring of Activities and Motor Symptoms in Parkinson's Disease

Zwartjes

Heida

Vugt

et al. 2010

IEEE Trans. Biomed. Eng.

122

107

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Abstract-Ambulatory monitoring of motor symptoms in Parkinson's disease (PD) can improve our therapeutic strategies, especially in patients with motor fluctuations. Previously published monitors usually assess only one or a few basic aspects of the cardinal motor symptoms in a laboratory setting. We developed a novel ambulatory monitoring system that provides a complete motor assessment by simultaneously analyzing current motor activity of the patient (e.g., sitting, walking, etc.) and the severity of many aspects related to tremor, bradykinesia, and hypokinesia. The monitor consists of a set of four inertial sensors. Validity of our monitor was established in seven healthy controls and six PD patients treated with deep brain stimulation (DBS) of the subthalamic nucleus. The patients were tested at three different levels of DBS treatment. Subjects were monitored while performing different tasks, including motor tests of the Unified PD Rating Scale (UPDRS). Output of the monitor was compared to simultaneously recorded videos. The monitor proved very accurate in discriminating between several motor activities. Monitor output correlated well with blinded UPDRS ratings during different DBS levels. The combined analysis of motor activity and symptom severity by our PD monitor brings true ambulatory monitoring of a wide variety of motor symptoms one step closer.

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“…It exist a variety of laboratory-based systems to quantitatively measure and analyse body movement. This includes systems for movement analysis of dystonia [72], tremor [11,33,95], bradykinesia [29,65], gait [8,48,61] and levodopa induced dyskinesias [37,55].…”

Section: Movement Pattern Analysismentioning

confidence: 99%

Stereotactic implantation of deep brain stimulation electrodes: a review of technical systems, methods and emerging tools

Hemm¹,

Wårdell²

2010

Med Biol Eng Comput

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Deep brain stimulation (DBS) has become increasingly important for the treatment and relieve of neurological disorders such as Parkinson's disease, tremor, dystonia and psychiatric illness. As DBS implantations, and any other stereotactic and functional surgical procedure, require accurate, precise and safe targeting of the brain structure, the technical aids for preoperative planning, intervention and postoperative follow up have become increasingly important. The aim of this paper is to give an overview, from a biomedical engineering perspective, of a typical implantation procedure and current supporting techniques.Furthermore emerging technical aids not yet clinically established are presented. This includes the state-of-the-art of patient specific simulation of DBS electric field, optical methods for intracerebral guidance, movement pattern analysis, new stimulation devices and trends related to neuroimaging, visualization and navigation. As DBS surgery already today is an information technology intensive domain an "intuitive visualization" interface for improving management of these data in relation to surgery is suggested.

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Quantitative assessment of bradykinesia in patients with parkinson's disease

Cited by 62 publications

References 10 publications

Lifecorder: A New Device for the Long-term Monitoring of Motor Activities for Parkinson's Disease

Lifecorder: A New Device for the Long-term Monitoring of Motor Activities for Parkinson's Disease

Ambulatory Monitoring of Activities and Motor Symptoms in Parkinson's Disease

Stereotactic implantation of deep brain stimulation electrodes: a review of technical systems, methods and emerging tools

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