Quantitative assessment of diabetic amyotrophy using magnetic resonance neurography—a case-control analysis

Hlis, Rocco; Poh, Feng; Bryarly, Meredith; Xi, Yin; Chhabra, Avneesh

doi:10.1007/s00330-019-06162-3

Cited by 18 publications

(8 citation statements)

References 32 publications

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“…Responding to the lack of quantitative systematic scientific investigation of the use of MRI or MRN in the evaluation of DA, Hlis employed MRN as a non-invasive diagnostic tool for the quantitative characterization of DA in 40 controls and 23 DA cases. 76 Nevertheless, using MRI or MRN in the early diagnosis of diabetic muscular atrophy is not feasible. Other studies have investigated the application of HRU in muscle evaluation.…”

Section: Diagnosis Of Diabetic Muscular Atrophymentioning

confidence: 99%

Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

Huang¹,

Wu²

2021

DMSO

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Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). The typical manifestation is a length-dependent "glove and sock" sensation. At present, diagnosis is mainly dependent on clinical manifestations. Since the pathogenesis is not clear, there are no effective treatment measures. Management consists mainly of glucose control, peripheral nerve nutrition, and other measures to delay the progress of the disease; early diagnosis is therefore crucial to improving prognosis and quality of life for patients with DPN. Due to the lack of obvious symptoms in 50% of patients and the low sensitivity of neuro-electrophysiology to small fibers, the missed diagnosis rate is high. Highresolution ultrasound (HRU), as a convenient noninvasive tool, has been proven by many studies to have excellent clinical value in diagnosing DPN. With the development of related new technology, HRU shows promise for the screening, diagnosing, and follow-up of DPN, which could serve as a biomarker and provide new diagnostic insights. In this paper, we review the ability of HRU to detect nerve cross-sectional area and blood flow, and echo and other image changes, and in showing the characteristics of peripheral nerve morphological changes in patients with DPN. We also explore the application of two other recent technological developments-shear wave elastography (SWE) and ultrasound scoring systems-in improving the diagnostic efficiency of HRU in peripheral neuropathy.

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Section: Diagnosis Of Diabetic Muscular Atrophymentioning

confidence: 99%

Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

Huang¹,

Wu²

2021

DMSO

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“…MRI of the lower spine is generally unrevealing in these patients; however, magnetic resonance neurography (MRN) may reveal abnormalities. On MRN, signals for fat and blood are suppressed on T2 images so that the nerve appears brighter than the surrounding tissue 42,43 . This approach can be used to examine single nerves or the plexus, although it may not be available at all imaging centers.…”

Section: Diabetic Lumbosacral Radiculoplexus Neuropathymentioning

confidence: 99%

Diabetic Neuropathies

Elafros,

Callaghan

2023

CONTINUUM: Lifelong Learning in Neurology

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OBJECTIVE This article provides an up-to-date review of the diagnosis and management of the most common neuropathies that occur in patients with diabetes. LATEST DEVELOPMENTS The prevalence of diabetes continues to grow worldwide and, as a result, the burden of diabetic neuropathies is also increasing. Most diabetic neuropathies are caused by hyperglycemic effects on small and large fiber nerves, and glycemic control in individuals with type 1 diabetes reduces neuropathy prevalence. However, among people with type 2 diabetes, additional factors, particularly metabolic syndrome components, play a role and should be addressed. Although length-dependent distal symmetric polyneuropathy is the most common form of neuropathy, autonomic syndromes, particularly cardiovascular autonomic neuropathy, are associated with increased mortality, whereas lumbosacral radiculoplexus neuropathy and treatment-induced neuropathy cause substantial morbidity. Recent evidence-based guidelines have updated the recommended treatment options to manage pain associated with distal symmetric polyneuropathy of diabetes. ESSENTIAL POINTS Identifying and appropriately diagnosing the neuropathies of diabetes is key to preventing progression. Until better disease-modifying therapies are identified, management remains focused on diabetes and metabolic risk factor control and pain management.

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“…[ 25 ] The cross- sectional area of these structures is also increased compared with controls. [ 26 ] However, these changes are nonspecific and can be seen in inflammatory radiculoneuropathies and radiculitis. Hlis et al .…”

Section: Aterial and M Ethodsmentioning

confidence: 99%

Diabetic Amyotrophy (Bruns-Garland Syndrome)

Vishnu¹,

Agarwal²,

Srivastava³

2022

Annals of Indian Academy of Neurology

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Background and Aims: Bruns-Garland syndrome (BGS) continues to be a contentious topic even 100 years after its discovery. Its lifelong incidence is 1% amongst diabetic individuals and affects middle aged-elderly individuals with type 2 diabetes mellitus (usually not poorly controlled). Methods: The data presented in this review was collated from studies published on PubMed, MEDLINE and Google Scholar in October 2021. The search words included: “Bruns-Garland syndrome”, “diabetic amyotrophy” and “diabetic lumbosacral radiculoplexus neuropathy” and “proximal diabetic neuropathy”. Results: The exact pathophysiology is debatable but an ischemic pathology (non-systemic microvasculitis) is most plausible. Its cardinal symptoms include acute onset of severe proximal lower extremity pain followed by weakness and wasting, some sensory loss, weight loss and autonomic symptoms. Conclusion: The prognosis is good as most patients improve to near- normal strength with pain cessation within 18 months of onset.

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Quantitative assessment of diabetic amyotrophy using magnetic resonance neurography—a case-control analysis

Cited by 18 publications

References 32 publications

Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

Diabetic Neuropathies

Diabetic Amyotrophy (Bruns-Garland Syndrome)

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