Quantitative assessment of first-pass perfusion of oesophageal squamous cell carcinoma using 64-section MDCT: initial observation

Chen, T.-W.; Yang, Zhi‐gang; Li, Y.; Li, Z.-L.; Yao, Jin; Sun, Jinhua

doi:10.1016/j.crad.2008.06.005

Cited by 19 publications

(12 citation statements)

References 21 publications

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“…11 In a study of 41 patients with esophageal squamous cell tumors, Chen et al showed that BV values increase with tumor angiogenesis. 12 Liu et al used CTP in the axillary region in 25 patients with breast carcinoma, and found that CTP is a good means of assessing angiogenesis in lymph nodes. 13 Bisdas et al demonstrated that perfusion parameters differentiate among primary tumors, recurrent tumors, and normal tissues in 77 patients with oropharynx and oral cavity cancer.…”

Section: Discussionmentioning

confidence: 99%

Is Computed Tomography Perfusion a useful Method for Distinguishing between Benign and Malignant Neck Masses?

et al. 2017

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Evaluation of neck masses is frequent in ear, nose, and throat clinics. Successful outcomes associated with neck mass are directly related to rapid diagnosis and accurate treatment for each patient. Late diagnosis of a malignant mass increases the magnitude of morbidity and the rate of mortality of the disease. Although magnetic resonance imaging and computed tomography (CT) examinations are important tools for evaluating head and neck pathologies, they do not allow functional evaluation. For this reason, CT perfusion (CTP) as a method of functional evaluation for distinguishing benign from malignant masses is gaining attention. The utility of CTP for distinguishing between benign and malignant mass lesions was investigated in 35 patients with masses in the neck (11 benign, 24 malignant). CTP was shown to be a useful method for identifying head and neck tumors and blood volume values to enable the differential diagnosis of benign and malignant head and neck tumors.

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Section: Discussionmentioning

confidence: 99%

Is Computed Tomography Perfusion a useful Method for Distinguishing between Benign and Malignant Neck Masses?

et al. 2017

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“…The basis of CT perfusion is the transport of a contrast material by blood flow through the intravascular space, and subsequently, the distribution of the contrast material between the intravascular and extravascular interstitial space [20],[21]. Previous studies using CT perfusion in esophageal and gastric cancer have found a significant correlation with blood volume [22]–[24] and permeability surface area product [22], and histological evaluation of micro vessel density [22]–[24] and Vascular Endothelial Growth Factor (VEGF) expression [25]. Likewise, Satoh et al [26] found a negative correlation between tumour perfusion and stromal density.…”

Section: Discussionmentioning

confidence: 99%

“…Makari et al [27] examined changes in tumour perfusion before and after chemo-radiation in esophageal squamous cell carcinoma and found a positive correlation between perfusion changes and tumour size reduction. Our baseline perfusion measures are in the same range as some studies [22], [28], and differs from other studies [24], [25]. The analysis software used in this study is based on two kinetic models: the maximum slope method to estimate tissue perfusion and Patlak method to estimate both blood volume and permeability (k trans ), which is the rate constant for transfer between the intravascular and extravascular (interstitial) spaces.…”

Section: Discussionmentioning

confidence: 99%

Computed Tomography (CT) Perfusion as an Early Predictive Marker for Treatment Response to Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer and Gastric Cancer - A Prospective Study

et al. 2014

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ObjectivesTo evaluate whether early reductions in CT perfusion parameters predict response to pre-operative chemotherapy prior to surgery for gastroesophageal junction (GEJ) and gastric cancer.Materials and MethodsTwenty-eight patients with adenocarcinoma of the gastro-esophageal junction (GEJ) and stomach were included. Patients received three series of chemotherapy before surgery, each consisting of a 3-week cycle of intravenous epirubicin, cisplatin or oxaliplatin, concomitant with capecitabine peroral. The patients were evaluated with a CT perfusion scan prior to, after the first series of, and after three series of chemotherapy. The CT perfusion scans were performed using a 320-detector row scanner. Tumour volume and perfusion parameters (arterial flow, blood volume and permeability) were computed on a dedicated workstation with a consensus between two radiologists. Response to chemotherapy was evaluated by two measures. Clinical response was defined as a tumour size reduction of more than 50%. Histological response was evaluated based on residual tumour cells in the surgical specimen using the standardized Mandard Score 1 to 5, in which values of 1 and 2 were classified as responders, and 3 to 5 were classified as nonresponders.ResultsA decrease in tumour permeability after one series of chemotherapy was positively correlated with clinical response after three series of chemotherapy. Significant changes in permeability and tumour volume were apparent after three series of chemotherapy in both clinical and histological responders. A cut-off value of more than 25% reduction in tumour permeability yielded a sensitivity of 69% and a specificity of 58% for predicting clinical response.ConclusionEarly decrease in permeability is correlated with the likelihood of clinical response to pre-operative chemotherapy in GEJ and gastric cancer. As a single diagnostic test, CT Perfusion only has moderate sensitivity and specificity in response assessment of pre-operative chemotherapy making it insufficient for clinical decision purposes.

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“…Tumour angiogenesis is important in oncology because it is critical for tumour growth, invasion and metastasis [4]. Tumours do not grow beyond 1–2 mm 3 in size without the development of new vessels [13].…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical staining measurements of angiogenic activity, known as MVD, have been shown to be an important prognostic factor. This process is, however, limited by its invasiveness and inability to provide information about vascular functionality in vivo [4,15]. Microbubbles increase the intensity of Doppler signals from blood for several minutes after their injection [16].…”

Section: Discussionmentioning

confidence: 99%

Time‐intensity curve parameters in colorectal tumours measured using double contrast‐enhanced ultrasound: correlations with tumour angiogenesis

Zhuang¹,

Zg²,

Hj³

et al. 2012

Colorectal Disease

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Quantitative assessment of first-pass perfusion of oesophageal squamous cell carcinoma using 64-section MDCT: initial observation

Cited by 19 publications

References 21 publications

Is Computed Tomography Perfusion a useful Method for Distinguishing between Benign and Malignant Neck Masses?

Is Computed Tomography Perfusion a useful Method for Distinguishing between Benign and Malignant Neck Masses?

Computed Tomography (CT) Perfusion as an Early Predictive Marker for Treatment Response to Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer and Gastric Cancer - A Prospective Study

Time‐intensity curve parameters in colorectal tumours measured using double contrast‐enhanced ultrasound: correlations with tumour angiogenesis

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