Quantitative Assessment of Foot Blood Flow by Using Dynamic Volume Perfusion CT Technique: A Feasibility Study

Abstract

Perfusion CT could be used to measure foot blood flow in both animals and humans. It can be a useful modality for the diagnosis of peripheral arterial disease by providing quantitative information on foot perfusion status.

CT Foot Perfusion Examination for Evaluation of Percutaneous Transluminal Angioplasty Outcome in Patients with Critical Limb Ischemia: A Feasibility Study

“…Perfusion parameters are influenced by macrovascular and microvascular functions of the foot, as opposed to ABI, which reflects the macrovascular status of the limb. Moreover, the perfusion parameter changes were greater in the dermal layer than in the muscle tissues, which has been reported in only 1 previous study of which we are aware (9). Finally, patients with clinical improvement who did not undergo an amputation presented higher post-PTA perfusion parameter values than patients with poor response who underwent an amputation after PTA.…”

“…They deduced that foot CT perfusion examination is feasible and reproducible and that PTA can induce slight changes in perfusion parameters. Recently, Hur et al (9) demonstrated the ability of CT perfusion technique to measure BF of the foot in animals and humans. The authors concluded that successful revascularization leads to significant increase of BF, especially in the dermal layer (9).…”

“…Recently, Hur et al (9) demonstrated the ability of CT perfusion technique to measure BF of the foot in animals and humans. The authors concluded that successful revascularization leads to significant increase of BF, especially in the dermal layer (9). The present study demonstrates statistically significant changes in perfusion parameters in patients with CLI after successful revascularization.…”

“…CT perfusion calculates the changes in tissue density after intravenous injection of contrast medium and allows functional evaluation of tissue vascularity. However, there are few studies on the role of CT perfusion in PAD (7)(8)(9). The purpose of the present study is to evaluate foot hypoperfusion in patients with critical limb ischemia (CLI) with the use of quantitative CT foot perfusion examination and estimate changes in perfusion parameters before and after successful percutaneous transluminal angioplasty (PTA).…”

Perfusion Assessment in Critical Limb Ischemia: Principles for Understanding and the Development of Evidence and Evaluation of Devices: A Scientific Statement From the American Heart Association

“…70 This imaging technique may also be able to quantify perfusion in the lower extremity and monitor revascularization treatment response. In a 2016 study by Hur et al, 71 perfusion CT was found to have a strong correlation with fluorescent microsphere blood flow analysis in rabbit foot models. The color-coded perfusion maps also correlated well with clinical and angiographic findings in patients with PAD who underwent revascularization.…”