Quantitative Assessment of Human Proteinases as Agents for Chemonucleolysis

Pm, Dando; Db, Morton; Dj, Buttle; Aj, Barrett

doi:10.1097/00007632-198802000-00010

Cited by 15 publications

(3 citation statements)

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“…MMPs are first secreted as zymogens and are activated in the extracellular space by the hydrolytic cleavage of inactive structural domains or oxidative modification of thiol groups [60]. Importantly, MMPs are involved in a wide range of biological processes and are closely associated with disease development [61][62][63].…”

Section: Matrix Metalloproteinases (Mmps)mentioning

confidence: 99%

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The Proteolysis of ECM in Intervertebral Disc Degeneration

Liang

Rongjing

et al. 2022

IJMS

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Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs throughout the human life span and is a major cause of lower back pain. Better elucidation of the molecular mechanisms involved in disc degeneration could provide a theoretical basis for the development of lumbar disc intervention strategies. In recent years, extracellular matrix (ECM) homeostasis has received much attention due to its relevance to the mechanical properties of IVDs. ECM proteolysis mediated by a variety of proteases is involved in the pathological process of disc degeneration. Here, we discuss in detail the relationship between the IVD as well as the ECM and the role of ECM proteolysis in the degenerative process of the IVD. Targeting ECM proteolysis-associated proteases may be an effective means of intervention in IDD.

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Section: Matrix Metalloproteinases (Mmps)mentioning

confidence: 99%

“…Dando et al described a rabbit IVD model in which intradisc injection of Cathepsins B resulted in proteoglycan breakdown and histological and imaging alterations of the IVD [62]. Further studies demonstrated that Cathepsins B was highly expressed in degenerating discs [63].…”

Section: Cathepsins Proteasesmentioning

confidence: 99%

The Proteolysis of ECM in Intervertebral Disc Degeneration

Liang

Rongjing

et al. 2022

IJMS

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“…Chemonucleolysis has been considered a minimally invasive treatment for cervical and lumbar disc herniation (LDH) for more than 50 years [1]. Although several enzymes (trypsin, hyaluronidase, cathepsin G, chymotrypsin, and calpain) have been proposed as therapeutic agents [2][3][4][5][6], only two enzymes (chymopapain and collagenase) have been used in clinical practice [1,7]. Chymopapain was introduced in July 1963 and was widely used throughout Europe, North America, and Australia [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Chemonucleolysis with Chondroitin Sulfate ABC Endolyase for Treating Lumbar Disc Herniation: Exploration of Prognostic Factors for Good or Poor Clinical Outcomes

Ishibashi¹

2020

Preprint

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Background and Objectives: Chondroitin sulfate ABC endolyase (condoliase) was launched as a new drug for chemonucleolysis in 2018. There are few Few studies assessed regarding its clinical outcomes, and many important factors matters still remain unclear. The purpose of this This study aimed is to clarify clarify the preoperative conditionsfactors for in which condoliase could beis highly effective. Materials and Methods: Of the 47 patients who received condoliase, 34 patients were enrolled in this study. The mean age of the patients was 33 years. The average disease duration since the onset of the disease was 8.6 months. We evaluated the patients’patient’s low back and leg painpains using a numericalNumerical rating scale (NRS) score at two time points (before therapy and 3 months after therapyadministration). We divided the patients into two groups ([good group [(G]:): NRS score improvement ≥ 50%, poor group (P): NRS score improvement &lt; 50%]. The parameters evaluatedSurvey items were age, disease disease duration, body mass index (BMI), and the presence or absence of positive or negative straight leg raising (SLR) test results. In additionMoreover, the loss of disc height loss and participation of preoperative radiological findings were also evaluated. Results: In terms of low back and leg pain, the G group were in 9/34 (26.5%) and 21/34 (61.8%) patients, respectively. Patients’. Patient’s age (low back pain G/P, 21.0/36.5 years)), was significantly loweryounger in the G group of low back pain (p = 0.001). High intensity change inof the protruded nucleus pulposus (NP) and the spinal canal occupancy by theof NP ≥ 40% were significantly highhighly observed in those withthe leg pain in the G groups (14/21,: p = 0.04; and 13/21,: p = 0.03, respectively). Conclusions: The efficacy of improvement inof leg pain was significantlyhighly correlated with high intensity change and size of the protruded NP. Condoliase was not significantly effective forto low back pain, but could might be expected have anthe effect onto younger patients.

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Percutaneous Treatments

Postacchini¹,

Mayer²

1999

Lumbar Disc Herniation

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Quantitative Assessment of Human Proteinases as Agents for Chemonucleolysis

Cited by 15 publications

References 0 publications

The Proteolysis of ECM in Intervertebral Disc Degeneration

The Proteolysis of ECM in Intervertebral Disc Degeneration

Chemonucleolysis with Chondroitin Sulfate ABC Endolyase for Treating Lumbar Disc Herniation: Exploration of Prognostic Factors for Good or Poor Clinical Outcomes

Percutaneous Treatments

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