Quantitative assessment of langerhans cells in actinic keratosis, bowen's disease, keratoacanthoma, squamous cell carcinoma and basal cell carcinoma

McArdle, John P.; Knight, B.A.; Halliday, GM; Muller, H. Konrad; Rowden, Geoffrey

doi:10.3109/00313028609059461

Cited by 53 publications

(16 citation statements)

References 22 publications

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“…[22] Similar LC count in the epithelium of OSCC and OED was observed in the present study [Table 1; Figure 7] and supported with the fact that the overlying epithelium of OSCC also exhibits dysplastic features and is exposed to oral carcinogens.…”

Section: Discussionsupporting

confidence: 94%

“…LCs recognize the antigenic products released by the tobacco and the neo-antigens generated by the dysplastic cells and migrate out to sensitize the T-cell in lymph nodes. [22] Previous studies have concluded similar findings and suggest that it is this LC depletion, rather than carcinogenic treatment that is a critical factor which leaves skin immunologically compromised and favors progression of the dysplastic process. [23] A similar phenomenon could be applicable to the observation of the present study.…”

Section: Discussionsupporting

confidence: 53%

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A comparative analysis of langerhans cell in oral epithelial dysplasia and oral squamous cell carcinoma using antibody CD-1a

Upadhyay¹,

Rao²,

Upadhyay

2012

J Can Res Ther

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 53%

A comparative analysis of langerhans cell in oral epithelial dysplasia and oral squamous cell carcinoma using antibody CD-1a

Upadhyay¹,

Rao²,

Upadhyay

2012

J Can Res Ther

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“…Increased numbers of Langerhans' cells (44,45) can be identified at the infiltrative margins of squamous neoplasms and are suspected to be "related to the invasive process which is localized to focal areas at the periphery of infiltrating tumors" (46). The highest density of OSM-labeled macrophages in this study was observed at the infiltrating margins of both KAs and SCCs.…”

Section: Discussionmentioning

confidence: 51%

Comparison of Oncostatin M Expression in Keratoacanthoma and Squamous Cell Carcinoma

et al. 2000

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Oncostatin M (OSM) is a 28-kDa glycoprotein, produced by stimulated macrophages and T lymphocytes, that inhibits the proliferation and induces differentiation of a number of different cell lines derived from solid tumors. To determine whether keratoacanthoma (KA) is unique or a variant of squamous cell carcinoma (SCC), we compared the immunohistochemical expression of OSM in the tumor cells and peri-and intratumoral macrophages of 21 mature KAs, 7 regressing KAs, and 27 SCCs. An inverse correlation was identified between OSM tumor labeling and the density of OSM-labeled tumor-associated macrophages for KAs (r ‫؍‬ ؊.4; P ‫؍‬ .09). OSM tumor expression was significantly more frequent and more intense in KAs than in SCCs (95% versus 63%; P < .01). In contrast, the density of OSM-labeled macrophages was significantly higher in SCCs compared with mature KAs (7/3 high power fields versus 4/3 high power fields; P ‫؍‬ .02). These OSM-positive macrophages were predominantly located at the advancing, infiltrative margins of both neoplasms. Regressing KAs demonstrated a decreased level of OSM tumor expression compared with mature KAs (53% versus 95%; P ‫؍‬ .001), but there was no difference in density of OSMlabeled macrophages. Both the above differences and the overlapping patterns of OSM expression suggest that KAs are a variant of SCC where OSM, possibly as an autocrine factor, may mediate KA's overwhelming but not absolute tendency to involute.

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“…Similar findings have previously been reported, with increased concentrations of Langerhans cells in the tumors of Bowen disease, squamous cell carcinomas, basal cell carcinomas, and in nonneoplastic epithelium adjacent to these neoplasms. 31,32 Our finding that the density of Langerhans cells is higher in pterygial epithelium than in normal conjunctiva suggests either that Langerhans cells are being retained in abnormal (pterygial) epithelium for a longer period than normal or that increased numbers of Langerhans cells are being actively attracted to pterygium by some unknown factor(s) released by the pterygium. On the other hand, another immunohistochemical study of pterygium found evidence of a chronic inflammatory process in pterygium, with most of the infiltrating lymphocytes being T cells.…”

Section: Distribution Of Langerhans Cellsmentioning

confidence: 86%

Distribution of Vimentin-Expressing Cells in Pterygium: An Immunocytochemical Study of Impression Cytology Specimens

Chen

Tseng

Tsai

et al. 2009

Cornea

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The vimentin-expressing epithelioid cells were present not only over the ocular surface of the pterygium but also in the normal-appearing conjunctiva adjacent to primary and recurrent pterygium. The increased density of Langerhans cells in pterygium might reflect a higher level of antigenic and mitogenic exposure in the conjunctiva. However, the significance of these 2 phenomena in the recurrence and pathogenesis of pterygium remains undetermined and merits further studies.

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Quantitative assessment of langerhans cells in actinic keratosis, bowen's disease, keratoacanthoma, squamous cell carcinoma and basal cell carcinoma

Cited by 53 publications

References 22 publications

A comparative analysis of langerhans cell in oral epithelial dysplasia and oral squamous cell carcinoma using antibody CD-1a

A comparative analysis of langerhans cell in oral epithelial dysplasia and oral squamous cell carcinoma using antibody CD-1a

Comparison of Oncostatin M Expression in Keratoacanthoma and Squamous Cell Carcinoma

Distribution of Vimentin-Expressing Cells in Pterygium: An Immunocytochemical Study of Impression Cytology Specimens

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