“…There is some evidence that motor fatigue in Polio survivors occurs at the level of the muscle, with changes in excitation contraction coupling, with some evidence also of centrally driven fatigue (Allen, Gandevia, and Middleton, 1997;Sharma et al, 1994;Sunnerhagen et al, 2000). Significantly greater motor fatigue of hand grip in Polio survivors compared with healthy controls has been quantified using decline in maximum voluntary contraction (Meldrum et al, 2007b), but it is uncertain how motor fatigue relates to the subjective perception of fatigue, mobility, function and well-being.…”