Quantitative assessment of myocardial perfusion during graded coronary stenosis by real-time myocardial contrast echo refilling curves

Masugata, Hisashi; Peters, Barry; Lafitte, Stéphane; Strachan, G. Monet; Ohmori, Koji; DeMaria, Anthony N.

doi:10.1016/s0735-1097(00)01046-9

Cited by 104 publications

(65 citation statements)

References 7 publications

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“…In cardiac imaging, CEUS has an established role in left ventricle opacification and endocardial border definition to assess myocardial function and ejection fraction [55][56][57]. The quantification of myocardial perfusion through reperfusion kinetics [57,58] is accurate in the detection of coronary artery stenosis [59], and provides similar results to SPECT and stress echocardiography [60]. In normal conditions during pharmacological stress, the myocardium is fully replenished by microbubbles 1 to 1.5 s after the end of a high-transmit-power pulse train [58], while in regions subserved by stenotic coronary arteries the rate of filling is slower depending upon the severity of stenosis (Fig.…”

Section: Clinical Applications Of Organ Perfusionmentioning

confidence: 99%

Assessment of tissue perfusion by contrast-enhanced ultrasound

Quaia

2010

Eur Radiol

102

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Section: Clinical Applications Of Organ Perfusionmentioning

confidence: 99%

Assessment of tissue perfusion by contrast-enhanced ultrasound

Quaia

2010

Eur Radiol

102

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“…Neither closed-chest MCE nor end-systolic triggering acquisition was validated with the established technique of microspheres; however, real-time acquisition is an accepted technique for MBF estimation. 44,45 Finally, we did not quantify absolute MBF. Recently, Vogel et al 14 demonstrated that normalizing A␤ obtained in the myocardial walls by the LV cavity signal intensity provides absolute measurements of MBF in humans.…”

Section: Raher Et Al Murine Contrast Echocardiographymentioning

confidence: 99%

In Vivo Characterization of Murine Myocardial Perfusion With Myocardial Contrast Echocardiography

et al. 2007

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Background-The ability to noninvasively evaluate murine myocardial blood flow (MBF) in vivo would provide an important tool for cardiovascular research. Myocardial contrast echocardiography (MCE) has been used to measure MBF; however, it has not been validated in mice. This study assesses whether MCE can evaluate MBF at rest and after vasodilation and measure the maximal augmentation (coronary reserve) of MBF in mice. Wild-type (WT) and nitric oxide synthase 3 (NOS3)-deficient (NOS3 Ϫ/Ϫ ) mice were studied. Methods and Results-MCE was performed at baseline and after intravenous infusion of acetylcholine or adenosine.Definity contrast agent was infused, and parasternal views were acquired in real-time mode. Replenishment curves of myocardial contrast were obtained, and rates of signal rise (␤) and plateau intensity (A) were calculated. MBF estimated by the product of A and ␤ (A␤) was compared with that measured with fluorescent microspheres. MCE analysis was feasible in 98% (52/53) of mice. MBF measured by microspheres increased with adenosine and correlated closely with A␤. There was no difference in MCE-derived MBF between WT and NOS3 Ϫ/Ϫ mice at rest. Adenosine infusion increased MBF by 3.0Ϯ0.6-fold in NOS3 Ϫ/Ϫ mice and 2.5Ϯ0.3-fold in WT (Pϭ0.58 between genotypes). Acetylcholine induced an increase of 2.4Ϯ0.2-fold in MBF in WT mice but did not increase MBF in NOS3 Ϫ/Ϫ mice (PϽ0.0005 versus WT). Conclusions-MBF, coronary reserve, and vasodilator responses can be evaluated accurately in the intact mouse by MCE.This method demonstrated a preserved coronary response to adenosine but an impaired acetylcholine-induced vasodilation in NOS3 Ϫ/Ϫ mice compared with WT mice.

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“…However, previous techniques using intermittent harmonic imaging have demonstrated limitations regarding the wall motion analysis and time required for image acquisition (2,5,7). Real time myocardial contrast echocardiography (RTMCE) is a recent technique that uses very low mechanical energy allowing the evaluation of microbubbles in the coronary circulation without their destruction, and simultaneous assessment of myocardial perfusion and function (7)(8)(9)(10).…”

Section: Pmm Dourado Et Almentioning

confidence: 99%

Evaluation of stunned and infarcted canine myocardium by real time myocardial contrast echocardiography

Dourado

Tsutsui

Mathias

et al. 2003

Braz J Med Biol Res

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Differentiation between stunned and infarcted myocardium in the setting of acute ischemia is challenging. Real time myocardial contrast echocardiography allows the simultaneous assessment of myocardial perfusion and function. In the present study we evaluated infarcted and stunned myocardium in an experimental model using real time myocardial contrast echocardiography. Sixteen dogs underwent 180 min of coronary occlusion followed by reperfusion (infarct model) and seven other dogs were submitted to 20 min of coronary occlusion followed by reperfusion (stunned model). Wall motion abnormality and perfusional myocardial defect areas were measured by planimetry. Risk and infarct areas were determined by tissue staining. In the infarct model, the wall motion abnormality area during coronary occlusion (5.52 ± 1.14 cm 2 ) was larger than the perfusional myocardial defect area (3.71 ± 1.45 cm 2 ; P < 0.001). Reperfusion resulted in maintenance of wall motion abnormality (5.45 ± 1.41 cm 2 ; P = 0.43 versus occlusion) and reduction of perfusional myocardial defect (1.51 ± 1.29 cm 2 ; P = 0.004 versus occlusion). Infarct size determined by contrast echocardiography correlated with tissue staining (r = 0.71; P = 0.002). In the stunned model, the wall motion abnormality area was 5.49 ± 0.68 cm 2 during occlusion and remained 5.1 ± 0.63 cm 2 after reperfusion (P = 0.07). Perfusional defect area was 2.43 ± 0.79 cm 2 during occlusion and was reduced to 0.2 ± 0.53 cm 2 after reperfusion (P = 0.04). 2,3,5-Triphenyl tetrazolium chloride staining confirmed the absence of necrotic myocardium in all dogs in the stunned model. Real time myocardial contrast echocardiography is a noninvasive technique capable of distinguishing between stunned and infarcted myocardium after acute ischemia.

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Quantitative assessment of myocardial perfusion during graded coronary stenosis by real-time myocardial contrast echo refilling curves

Abstract: In an open-chest dog model, parameters derived from microbubble refilling of the imaging field by real-time MCE correlate well with myocardial blood flow and can identify coronary stenosis.

Cited by 104 publications

References 7 publications

Assessment of tissue perfusion by contrast-enhanced ultrasound

Assessment of tissue perfusion by contrast-enhanced ultrasound

In Vivo Characterization of Murine Myocardial Perfusion With Myocardial Contrast Echocardiography

Evaluation of stunned and infarcted canine myocardium by real time myocardial contrast echocardiography

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