Quantitative assessment of protein content in irradiated human skin

Lahtinen, Tapani; Nuutinen, Juhani; Alanen, E.; Turunen, Mikael J.; Nuortio, Lauri; Usenius, Taina; Hopewell, J. W.

doi:10.1016/s0360-3016(98)00439-8

Cited by 21 publications

(15 citation statements)

References 10 publications

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“…This aim derives from the fact that skin‐to‐fat TDC values have shown promise as a way to characterize localized skin water changes in many clinically related circumstances. These include water changes associated with weight loss (Laaksonen et al ., ), assessment of oedema associated with various types of skin irritation (Nuutinen et al ., ; Lahtinen et al ., ; Miettinen et al ., ), diabetic skin changes (Mayrovitz et al ., ,b) and changes associated with the menstrual cycle (Mayrovitz et al ., ). TDC values are also used to assess lymphoedema (Mayrovitz, ; Mayrovitz et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Age‐related changes in male forearm skin‐to‐fat tissue dielectric constant at 300 MHz

Mayrovitz

Grammenos

Corbitt

et al. 2015

Clin Physio Funct Imaging

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Prior research suggests that tissue dielectric constant (TDC) values are useful to assess localized skin water in females for early diagnosing breast cancer treatment-related lymphoedema and TDC values in young adults have shown gender differences. However, no TDC data are available for older males nor have ageing effects been studied despite known shifts in water state and other skin age-related changes. Thus our goals were to (i) characterize TDC values at various skin depths in young and older males, (ii) determine the dependence of these values on body composition parameters and (iii) establish inter-arm TDC ratios for use as normal male reference values. TDC measurements were made to depths of 0·5, 1·5, 2·5 and 5·0 mm bilaterally on volar forearm skin in 60 males in three groups of 20 that had mean ages ± SD of 24·0 ± 0·9, 40·0 ± 12·9 and 71·0 ± 8·0 years. Total body fat and water percentages were determined via bioimpedance at 50 KHz. Results showed that (i) for all age groups TDC values decreased with increasing depth, (ii) TDC values were not statistically different among age groups except at a depth of 0·5 mm, (iii) TDC values were highly negatively correlated with total body fat and (iv) inter-arm ratios varied little among age groups and depths. It is concluded that (i) age-related larger TDC values at only the shallowest depth is consistent with skin water shifting state from bound to more mobile in the oldest group and (ii) inter-arm ratios at any depth provide a basis to test for unilateral oedema.

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Section: Introductionmentioning

confidence: 97%

Age‐related changes in male forearm skin‐to‐fat tissue dielectric constant at 300 MHz

Mayrovitz

Grammenos

Corbitt

et al. 2015

Clin Physio Funct Imaging

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show abstract

“…Thus, one aim of this study was to test this hypothesis by measuring skin TDC values to several skin depths in groups of younger and older women. Further, because skin-to-fat TDC values show promise as a way to characterize skin water changes in a variety of circumstances (18)(19)(20)(21)(22)(23)(24)(25)(26)(27) and as a tool for lymphedema assessment (28-32), a secondary aim was to establish reference ranges suitable for use with young and older women.…”

mentioning

confidence: 99%

Age‐related differences in tissue dielectric constant values of female forearm skin measured noninvasively at 300 MHz

Mayrovitz

Singh

Akolkar

2015

Skin Research and Technology

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“…Dielectric properties of tissues are primarily influenced by tissue water content . As such, dielectric techniques have been used to assess the water content of skin and subcutaneous tissues at a range of anatomic sites using an open‐ended coaxial probe method . A commercial device (MoistureMeter‐D, Delftin Technologies, Kuopio, Finland) has been validated .…”

Section: Resultsmentioning

confidence: 99%

“…This was attributed to a decrease in extracellular fluid content. A follow‐up study, conducted 2 years later, compared the dielectric constant of the irradiated skin to fibrosis palpation scores . A statistically significant positive correlation between the dielectric constant and subcutaneous fibrosis score was observed, suggesting that an increased dielectric constant could be used as an indicator of progressing fibrosis.…”

Section: Resultsmentioning

confidence: 99%