Quantitative Assessment of^99mTc-Depreotide Uptake in Oesophageal Cancer and Precursor Conditions and Its Reflection in Immunohistochemically Detected Somatostatin Receptors

Abstract

Background. Somatostatin receptors (SSTRs) are over-expressed in several tumors making it possible for imaging with labelled SSTR. A previous study showed feasibility to image oesophageal cancer with SSTR analogue 99mTc-depreotide. Purpose. (1) To investigate expression of the SSTRs in different types of esophageal carcinoma and (2) to correlate such an expression with 99mTc-depreotide uptake in these lesions. Material and Methods. Total 28 patients (17 with esophageal cancer and 11 with Barrett's esophagus) were examined with 99mTc-depreotide scintigraphy. The SSTR2A, SSTR2B, SSTR3, and SSTR5 were analyzed immunohistochemically in the lesion samples. Results. Among the patients with adenocarcinoma 10/11 expressed different amounts of SSTRs, while SSTRs were absent in 5/6 patients with Squamous cell carcinoma (Sqcc). There was no correlation neither between the 99mTc-depreotide uptake and the amount of SSTRs nor between the amount of SSTRs and differentiation grade of the tumor. Conclusions. (1) SSTRs are expressed in esophageal carcinoma and more abundantly so in adenocancer specimens; (2) in vivo 99mTc-depreotide uptake does not obviously correlate with the immunohistochemically detection of SSTRs of different subtypes in esophageal carcinoma.

Targets, Therapies and the Role of Serial Biopsies for Prognostication and Assessing Changes to Tumour Biology in Oesophageal and Oesophagogastric Junction Cancers

“…nanoparticles and Raman spectroscopy), fluorodeoxyglucose-positron emission tomography/computed tomography at 4-8 weeks after completing treatment is the test of choice for identifying metastasis after treatment with chemoradiation. [47][48][49][50][51][52][53] Oesophagogastroduodenoscopy Oesophagogastroduodenoscopy (OGD) enables direct visualization, tissue retrieval, therapeutic resection and ablation. While some advocate for using OGD following definitive chemoradiation to evaluate for residual tumour, others advise caution given its low sensitivity and poor positive predictive value.…”

Metastatic Esophageal Adenocarcinoma Showing 68Ga-DOTATATE Uptake

“…Therefore, cases showing 68 Ga-DOTATATE uptake in several nonneuroendocrine tumors have been reported in the literature 2,3 . Herlin et al 4 used 99m Tc-depreotide to demonstrate that esophageal adenocarcinoma has significant SSTR expression. The presence of a significant number of somatostatin ( D ) cells in the columnar epithelium of the stomach and the association of Barrett esophagus as a precursor lesion in the majority of esophageal adenocarcinomas are considered to explain this SSTR expression 5 .…”