Quantitative Assessment of the Associations Between Interleukin‐8 Polymorphisms and Periodontitis Susceptibility

Chen, Xing; Liu, Zhong; Ding, Cheng

doi:10.1902/jop.2014.140450

Cited by 27 publications

(20 citation statements)

References 33 publications

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“…Recent studies have indicated that polymorphisms in IL-8 could influence the development of various diseases, including acne vulgaris, glioma, gastric diseases, periodontitis, osteoarthritis, ovarian cancer, and oral cancer, as well as acute pancreatitis He et al, 2014;Chen et al, 2015;Hussain et al, 2015;Koensgen et al, 2015;Liu et al, 2015;Ramis et al, 2015). Wang et al (2013) observed, in a meta-analysis of 1324 patients with oral cancer and 1879 healthy controls, that the AA and AT genotypes of IL-8 rs4073 was correlated with an increased risk of oral cancer in a Caucasian population.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, He et al (2014) reported, in a case-control study with 150 osteoarthritis patients and 150 controls, that the TT genotype and the T allele of IL-8 rs4073 and rs2227306 polymorphisms conferred an elevated risk of osteoarthritis. Chen et al (2015) reported that the IL-8 rs407 polymorphism may be involved in periodontitis susceptibility in Brazilian and Asian populations, while Koensgen et al (2015) reported a correlation between the TT genotype of IL-8 rs2227306 and a higher risk of ovarian cancer. Hussain et al (2015) hypothesized that elevated IL-8 levels and the IL-8 rs4073 genetic variant may be correlated with acne vulgaris in a Pakistani population and Liu et al (2015) reported that the AA genotype of the IL-8 rs4073 polymorphism conferred a significantly higher risk of glioma, compared to the TT genotype.…”

Section: Discussionmentioning

confidence: 99%

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Role of IL-8 rs4073 and rs2227306 polymorphisms in the development of primary gouty arthritis in a Chinese population

2016

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ABSTRACT. In this study, we investigated the role of two single nucleotide polymorphisms in the promoter region of the interleukin-8 gene (IL-8; rs4073 and rs2227306) in the susceptibility to primary gouty arthritis in a Chinese population. Three hundred and twelve patients with primary gouty arthritis and 340 healthy controls were recruited from the Yan'an University Affiliated Hospital between January 2014 and March 2015. The IL-8 rs4073 and rs2227306 polymorphisms were genotyped by polymerase chain reaction combined with restriction fragment length polymorphism. Unconditional multiplelogistic regression analysis revealed that the TT genotype of rs4073 was correlated with primary gouty arthritis risk, compared to the AA genotype [adjusted odds ratio (OR) = 1.65, 95% confidence interval (CI) = 1.08-2.54; P = 0.02]. In addition, the IL-8 rs4073 T allele was associated with a significant elevated risk of primary gouty arthritis, in comparison to the A allele (OR = 1.34, 95%CI = 1.07-1.67; P = 0.01). However, we observed no significant relationship between the IL-8 2 Y.X. Cui et al.Genetics and Molecular Research 15 (4): gmr15048511 rs2227306 polymorphism and primary gouty arthritis risk. The results of this study suggest that the IL-8 rs4073 polymorphism could be a marker for primary gouty arthritis development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role of IL-8 rs4073 and rs2227306 polymorphisms in the development of primary gouty arthritis in a Chinese population

2016

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“…This meta-analysis evidenced that the IL-8 −251A/T polymorphism is related with a decreased risk of periodontitis in a Brazilian mixed population and an increased risk of periodontitis in an Asian population. The IL-8 gene has q13-q12 localization on chromosome 4, where the −251 A/T variant is related to an increase in the transcriptional activity of this cytokine [23]. The evidence that IL-8 −251A/T A allele is associated with higher expression of IL-8 can be observed in patients with chronic periodontitis in which higher IL-8 levels in the gingival crevicular fluid than healthy individuals were found.…”

Section: Resultsmentioning

confidence: 99%

“…The evidence that IL-8 −251A/T A allele is associated with higher expression of IL-8 can be observed in patients with chronic periodontitis in which higher IL-8 levels in the gingival crevicular fluid than healthy individuals were found. In addition, the expression of IL-8 in gingival epithelial cells can be induced by Porphyromonas gingivalis and Tannerella forsythia [23], bacteria commonly associated with periodontitis. It is important to note that although a very low genetic diversity was observed for the −845T/C polymorphism, the authors verified that Brazilian individuals with variant genotypes presented a higher risk of chronic periodontitis [23].…”

Section: Resultsmentioning

confidence: 99%

Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants

Silva

Carvalho

Alves

et al. 2017

International Journal of Dentistry

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Purpose. This work aimed to synthesize the results of recent meta-analysis focusing on polymorphism in inflammatory mediators and its relation with the risk of periodontitis development. Materials and Methods. A systematic search was conducted using databases for publications prior to October 2016. Three examiners extracted data from articles with a clear association between polymorphisms in the inflammatory mediator gene and the development of periodontitis through meta-analysis using the fixed or randomized statistical models to calculate the Odds Ratio with values of P < 0.05 considered significant. Results. A total of 13 meta-analysis articles with 25 polymorphisms in seven interleukins (IL-1A, IL-1B, IL-4, IL-6, IL-8, IL-10, and IL-18), three cellular receptors (Fcγ receptors: FCGR2A, FCGR3A, and FCGR3B), and five inflammatory mediators (COX-2, MMP-2, MMP-3, MMP-8, and MMP-9), with a total of 71,531 participants, approaching different classifications of the disease. Conclusion. The study demonstrated that polymorphisms in the IL-1A, IL-1B, IL-6, IL-10, MMP-3 (chronic form), and MMP-9 (chronic form) polymorphisms were significantly associated with the risk of developing periodontitis, whereas other polymorphisms in the IL-4, IL-8, IL-18, Fcγ, COX-2, MMP-2, MMP-3 (aggressive), MMP-8, and MMP-9 (aggressive) polymorphisms had no significant association with risk of developing periodontitis.

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“…The meta‐analysis in Song et alanalyzed the combined effect of 2 of the Nibali TNF studies and found no significance. The IL8 meta‐analysis by Chen et al included 3 of the studies described here but the only significant observation was that T allele rs4073 was associated with increased risk of periodontitis in a Brazilian mixed population (includes some African background), which also showed marginal association of the other IL8 SNP (rs2227532) . The studies reported in this review nearly all had small subject numbers: most had fewer than 70 affected individuals (some much less), particularly of African descent.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Genetic polymorphisms and periodontal disease in populations of African descent: A review

Gonçalves

Harris

Elmariah

et al. 2017

J of Periodontal Research

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Aggressive periodontitis is a rare but rapidly progressing form of periodontal disease that usually affects otherwise systemically healthy individuals, at a young age. It usually affects first molars and incisors, which are usually lost if treatment is not properly and early rendered. Although of low prevalence, it affects individuals of African descent at a higher prevalence, and usually multiple members within the same family. Several studies have been performed in the attempt to evaluate specific single nucleotide polymorphisms (SNPs) that could be associated with this disease. To the best of our knowledge, the present article provides the first review of the literature focusing on studies that evaluated SNPs in patients of African descent with aggressive periodontitis. Several SNPs have been evaluated in different genes according to their role in the pathogenesis of the disease, with positive and negative associations (such as IL1, FCGR3B, FPR1, LTF, CYBA, GLT6D1, TLR4) with both the localized and generalized forms of aggressive periodontitis. Given the complexity of periodontitis, the difficulty in gathering large cohorts diagnosed with this rare form of disease, and the fact that candidate gene studies may only determine part of the genetic risk of a disease, the search for specific SNPs associated with aggressive periodontitis seems to be a long one, most likely to result in the combination of multiple SNPs, in multiple genes.

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Quantitative Assessment of the Associations Between Interleukin‐8 Polymorphisms and Periodontitis Susceptibility

Abstract: This meta-analysis indicated that both IL-8 -251A/T and -845T/C polymorphisms may be involved in the development of periodontitis in a Brazilian mixed population, whereas the -251A/T allele T appeared to be a risk factor for periodontitis in Asians.

Cited by 27 publications

References 33 publications

Role of IL-8 rs4073 and rs2227306 polymorphisms in the development of primary gouty arthritis in a Chinese population

Role of IL-8 rs4073 and rs2227306 polymorphisms in the development of primary gouty arthritis in a Chinese population

Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants

Genetic polymorphisms and periodontal disease in populations of African descent: A review

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