The article presents analytical data for assessing cyclical trends in morbidity and mortality, correlation analysis of morbidity due to zooanthroponoses, and trend analysis of biological threats based on statistical data for the Ryazan region from 2017 to 2021. This analysis made it possible to compile a matrix of pairwise Pearson correlation coefficients for infectious and parasitic diseases of animals and humans, which are zooanthroponoses, and to reveal a correlation between the incidence of humans and animals.The highest score rank (2.208) and correlation coefficient (0.88) are typical for tuberculosis caused by mycobacteria. This disease is zooanthroponosis and is particularly dangerous. The second place of the trend is occupied by bacteria of the genus Salmonella (point rank — 1.362, correlation coefficient — 0.75). The third, fourth and fifth places of the trend are occupied by acute intestinal infections caused by Staphylococcus aureus (score rank —0.577, correlation coefficient — 0.79), Escherichia coliform bacteria (score rank—0.397, correlation coefficient — 0.82), Enterobacter, Citrobacter, Klebsiella (score rank — 0.308, correlation coefficient — 0.87).