Quantitative Behavioral Parameters as Toxicity Biomarkers: Fish Responses to Waterborne Cadmium

Eissa, Bettina Lorena; Ossana, Natalia Alejandra; Ferrari, Lucrecia; Salibián, Alfredo

doi:10.1007/s00244-009-9434-4

Cited by 37 publications

(15 citation statements)

References 39 publications

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“…It is possible that the observed discrepancy in Cd effects on locomotory behavior could partially be due to the use of different parameters for final assessment of the hypoactive or hyperactive nature of behavioral alterations. For example, while activity index decreased in Cd-exposed A. facetum, an increase in swimming velocity was observed at the same time (Eissa et al, 2010).…”

Section: Description Of Aop For Growth Impairment By Cadmiummentioning

confidence: 96%

“…Hypoactivity in response to Cd exposure has been observed in common carp (Eissa et al, 2006) and in Astraloherus facetum, a fish native to Argentina (Eissa et al, 2010). However, induction of hyperactivity by Cd has also been reported, for example, for bluegill sunfish (Ellgaard et al, 1978), rainbow trout (Majewski and Giles, 1981) and Atlantic salmon (Peterson et al, 1983).…”

Section: Description Of Aop For Growth Impairment By Cadmiummentioning

confidence: 96%

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Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish

et al. 2015

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Adverse outcome pathways (AOPs) organize knowledge on the progression of toxicity through levels of biological organization. By determining the linkages between toxicity events at different levels, AOPs lay the foundation for mechanism-based alternative testing approaches to hazard assessment. Here, we focus on growth impairment in fish to illustrate the initial stages in the process of AOP development for chronic toxicity outcomes. Growth is an apical endpoint commonly assessed in chronic toxicity tests for which a replacement is desirable. Based on several criteria, we identified reduction in food intake to be a suitable key event for initiation of middle-out AOP development. To start exploring the upstream and downstream links of this key event, we developed three AOP case studies, for pyrethroids, selective serotonin reuptake inhibitors (SSRIs) and cadmium. Our analysis showed that the effect of pyrethroids and SSRIs on food intake is strongly linked to growth impairment, while cadmium causes a reduction in growth due to increased metabolic demands rather than changes in food intake. Locomotion impairment by pyrethroids is strongly linked to their effects on food intake and growth, while for SSRIs their direct influence on appetite may play a more important role. We further discuss which alternative tests could be used to inform on the predictive key events identified in the case studies. In conclusion, our work demonstrates how the AOP concept can be used in practice to assess critically the knowledge available for specific chronic toxicity cases and to identify existing knowledge gaps and potential alternative tests.

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Section: Description Of Aop For Growth Impairment By Cadmiummentioning

confidence: 96%

Section: Description Of Aop For Growth Impairment By Cadmiummentioning

confidence: 96%

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish

et al. 2015

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“…This relationship formed the basis for the EPA's hardness-dependent criteria for dissolved copper in aquatic environments (EPA 1985). However, it has also been reported that aquatic organisms exposed to elevated levels of heavy metals can show a temporary increase in activity during the period of initial exposure (Eissa et al 2009). Therefore, the snails in the low hardness treatment groups may have shown temporarily elevated levels of activity following exposure to the copper treatments.…”

Section: Discussionmentioning

confidence: 99%

Can Copper‐Based Substrates Be Used to Protect Hatcheries from Invasion by the New Zealand Mudsnail?

Hoyer

Myrick

2012

N American J Aquac

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CAN COPPER-BASED SUBSTRATES BE USED TO PROTECT HATCHERIES FROM INVASION BY THE NEW ZEALAND MUDSNAIL?Aquaculture facilities throughout North America are at risk of invasion by the New Zealand mudsnail (Potamopyrgus antipodarum). Mudsnails can enter facilities in several ways including by crawling through effluent pipes. There is evidence to suggest that lining the insides of these pipes with copper-based substrates to create a contact deterrent could reduce the risk of mudsnail invasion. However, before copper-based deterrents can be recommended for wide-scale use, it is important that we understand how these materials perform across the range of physicochemical conditions common to hatcheries. The goal of this project was to evaluate the relative ability of four types of copper-based materials (copper sheet; SC (0.323 mm, 99.9% pure), copper mesh; MC (6.3 opening/cm, 99% pure), copper-based ablative anti-fouling paint; AP (Vivid Antifouling Paint, 25% cuprous thiocyanate as the active ingredient), and copper-based nonablative anti-fouling paint; NP (Sealife 1000, 39% cuprous oxide as the active ingredient)) to serve as effective mudsnail contact deterrents across a range of water temperatures (8, 12, 18, and 24° C), hardness (75, 125, 175, and 300 mg/L as CaCO 3 ), pH (6, 7, and 8.

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“…At the cellular level, heavy metals can cause a number of adverse effects, such as alterations in the communication between cells and in the interaction with intracellular signal transduction proteins, which may in turn lead to alterations in cell growth and differentiation (Goering et al 1995). More recently, it has been shown that sublethal Cd also causes important changes in the swimming activity of C. carpio in captivity (Eissa 2009;Eissa et al 2006Eissa et al , 2009Eissa et al , 2010.…”

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confidence: 96%

Energy balance of juvenile Cyprinus carpio after a short-term exposure to sublethal water-borne cadmium

Ferrari

Eissa

Salibián

2011

Fish Physiol Biochem

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Stress in fish can be assessed by means of a bioenergetic approach, based on the evaluation of changes in their physiological parameters. The objective of this study was to determine the impact of sublethal water-borne cadmium (Cd) on the energetic balance of juvenile Cyprinus carpio under laboratory conditions after a short-term exposure. Fish were exposed to a concentration of Cd (0.15 mg Cd l(-1)) for 2 weeks. This concentration is environmentally realistic since it is usually found, even at higher values, in heavily polluted periurban water bodies of Argentina. No mortality was recorded among the animals used in the experiments. Food intake, food assimilation and assimilation efficiency, fecal production, liver glycogen content, oxygen consumption, oxygen extraction efficiency, specific metabolic rate, ammonia excretion and ammonia quotient (AQ), condition factor, and liver somatic index were determined. The overall balance was expressed as the scope for growth (SFG). The morphological indices and the liver glycogen content of Cd-exposed fish showed no significant differences when compared to those of controls. There was a significant decrease in the food intake, fecal production, and food assimilation rates as well as in AQ; the SFG exhibited a highly significant decrease. The remaining parameters (assimilation efficiency, oxygen consumption, oxygen extraction efficiency, specific metabolic rate, and ammonia excretion) increased after the exposure to Cd. We concluded that the sub-chronic exposure of Cyprinus carpio to a sublethal concentration of Cd causes important alterations in the energy-related homeostasis of fish. Most of the responses are indicative of physiological adaptations to compensate an increased energy requirement due to the impairments caused by the metal.

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Quantitative Behavioral Parameters as Toxicity Biomarkers: Fish Responses to Waterborne Cadmium

Cited by 37 publications

References 39 publications

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish

Can Copper‐Based Substrates Be Used to Protect Hatcheries from Invasion by the New Zealand Mudsnail?

Energy balance of juvenile Cyprinus carpio after a short-term exposure to sublethal water-borne cadmium

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