2016
DOI: 10.1016/j.aca.2016.07.021
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Quantitative bioimaging of platinum group elements in tumor spheroids

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Cited by 34 publications
(28 citation statements)
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“…They performed an on tissue chemical derivatization using diethyldithiocarbamate to overcome platinum's low ionization efficiency in MALDI MSI . They observed an accumulation of platinum in the periphery and the core of the MCTS, as has been observed previously by LA‐ICP‐MS . However they were also able to identify an inactive methionine bound metabolite localized to the core of the MCTS showing that MALDI can provide additional information about drug penetration into MCTS with appropriate sample preparation.…”
Section: Analysis Techniques For Investigating Mctsmentioning
confidence: 58%
See 1 more Smart Citation
“…They performed an on tissue chemical derivatization using diethyldithiocarbamate to overcome platinum's low ionization efficiency in MALDI MSI . They observed an accumulation of platinum in the periphery and the core of the MCTS, as has been observed previously by LA‐ICP‐MS . However they were also able to identify an inactive methionine bound metabolite localized to the core of the MCTS showing that MALDI can provide additional information about drug penetration into MCTS with appropriate sample preparation.…”
Section: Analysis Techniques For Investigating Mctsmentioning
confidence: 58%
“…They suggest that the localization of the inactive metabolite to the necrotic core is a product of increased detoxification in this area or an expulsion of this product from the quiescent layer. This quiescent layer is consistently devoid of platinum based chemotherapeutics, despite complete penetration of the drugs, suggesting that these cells possess detoxification or drug efflux mechanisms.…”
Section: Analysis Techniques For Investigating Mctsmentioning
confidence: 99%
“…Gelatin has good solubility, which makes it possible to mitigate the problems associated with homogenates from raw animal tissues. [22][23][24][25] However, the obvious phenomenon of elementdependent heterogeneities is found in both gelatin and agarose-gel films. This is caused by the so-called "coffee stain" (visible in the elemental image since higher concentrations are found at the edges) and the "Marangoni" (visible as higher elemental concentrations in the center) effect.…”
Section: Introductionmentioning
confidence: 99%
“…The tedious preparation and characterisation, and the susceptibility towards systematic errors has encouraged investigations of other standard materials which are easier to manufacture, offer improved traceability and show less variability. Hydrocolloid gel-based materials such as gelatine-based standards are becoming increasingly popular for the calibration of elements in biological tissues as similarities in their composition mitigate the problems associated with homogenates from raw animal tissues 15,[24][25][26] . Three major methods for the fabrication of gelatine standards are described in literature: pipetted films 27 , spotted droplets 24 and cryosections 28 .…”
Section: Introductionmentioning
confidence: 99%