Quantitative Bone Scanning: A Method for Assessing Response of Bone Metastases to Treatment

Citrin, Dennis L.; Tuohy, J. B.; Bessent, R. G.; Greig, W. R.; Blumgart, Leslie H.

doi:10.1016/s0140-6736(74)90618-7

Cited by 32 publications

(6 citation statements)

References 2 publications

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“…Quantitative evaluation, which comprises a method previously investigated in bone tumors (25) , has not been previously applied to stress fractures and sports medicine. To our knowledge, there have been no studies retrospectively or prospectively investigating the application of a semi-quantitative evaluation using the ROI technique in relation to stress fracture outcomes.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of focal scintigraphic findings in clinically suspected cases of tibial stress fracture

2018

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ObjectiveTo investigate the correlation between tracer uptake on bone scintigraphy and recovery time in patients with tibial stress fracture.Materials and MethodsWe evaluated two groups of athletes: those with clinical suspicion and a radiological diagnosis of tibial stress fracture (TSF group, n = 21); and those with no symptoms or evidence of fracture (control group, n = 10). All subjects underwent bone scintigraphy and magnetic resonance imaging with a maximum interval of 7 days between the assessments.ResultsUsing the region of interest technique, we obtained a quantitative evaluation index, comparing affected and unaffected legs. The mean uptake of 99mTc-MDP was significantly higher in the TSF group than in the control group (2.54 ± 0.77 vs. 1.05 ± 0.11; p < 0.001).ConclusionIn our sample of athletes, determining the bone scintigraphy uptake indices provided an objective method to estimate the appropriate recovery time after a tibial stress fracture.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of focal scintigraphic findings in clinically suspected cases of tibial stress fracture

2018

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“…Serial bone scans, however, can be used to monitor the response of bone metastases to therapy, either by visual inspection of the images (Galasko and Doyle, 1972;Citrin and McKillop, 1978) or by measuring changes in tumour : normal bone activity ratios (Citrin et al, 1974;Gillespie et al, 1975). Even in patients with other evidence of bone metastases, serial scans are likely to give a more accurate reflection of the patients' status than clinical or radiographic changes (Galasko and Doyle, 1972;Citrin et al, 1974;Citrin and McKillop, 1978).…”

Section: Discussionmentioning

confidence: 99%

The prognostic and therapeutic implications of the positive radionuclide bone scan in clinically early breast cancer

McKillop

Blumgart

Wood

et al. 1978

Journal of British Surgery

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Seventy-five women with clinical stage I or stage II carcinoma of the breast have had radionuclide bone scans at the time of presentation and at 6-monthly intervals during a mean follow-up period of 39 months. Patients with evidence of metastases on bone scan, either at the time of presentation or during follow-up, had significantly higher mortality and morbidity rates than those with persistently negative scans. Whatever the clinical stage, breast cancer patients with a positive bone scan have a very poor short term prognosis and local therapy to the breast is inadequate. A plan is outlined which incorporates the patient's bone scan status into the decision to introduce endocrine therapy or chemotherapy.

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“…Less attention was paid to the possibility of using bone seeking radiopharmaceuticals for assessing the response to therapy of osseous metastases, although radioactivity uptake of metastatic bone lesions has been found to be diminished after irradiation (2,4,7,8), chemotherapy and/or hormonal treatment (3,5,6,10,11,12,13). Work published on this subject has not yet clarified completely the type of scintigraphic changes to be expected in responding patients, because unchanged positive scintigrams were also found during successful treatment of osseous metastases (1,9) and initially, during the first months, some authors even registered an increased uptake after therapy which was followed by a gradual decline (4, 6, 7).…”

Section: Introductionmentioning

confidence: 99%

Serial Bone Scintigraphy for Assessing the Effectiveness of Treatment of Osseous Metastases from Prostatic Cancer

Langhammer¹,

Sintermann²,

G³

et al. 1978

Nuklearmedizin

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130 serial bone scintigrams were performed to evaluate the course of skeletal metastases under treatment in 36 patients with prostatic cancer. During a successful treatment scintigraphic controls revealed a significant decrease of the metastatic 99mTc-diphosphonate uptake in 14 patients and sometimes even a complete normalization of the skeletal radioactivity distribution, whereas a progression characterized by an increased multifocal radioactivity concentration was registered in 16 patients indicating the failure of the initiated therapy. Based on these results of follow-up studies scintigraphic bone imaging can be recommended for the assessment of the effectiveness of on-going therapy of skeletal metastases.

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Quantitative Bone Scanning: A Method for Assessing Response of Bone Metastases to Treatment

Cited by 32 publications

References 2 publications

Prognostic value of focal scintigraphic findings in clinically suspected cases of tibial stress fracture

Prognostic value of focal scintigraphic findings in clinically suspected cases of tibial stress fracture

The prognostic and therapeutic implications of the positive radionuclide bone scan in clinically early breast cancer

Serial Bone Scintigraphy for Assessing the Effectiveness of Treatment of Osseous Metastases from Prostatic Cancer

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