Quantitative changes in mental health measures with 3MDR treatment for Canadian military members and veterans

Jones, Chelsea; Smith-MacDonald, Lorraine; Brown, Matthew; Pike, Ashley; Vermetten, Eric; Brémault‐Phillips, Suzette

doi:10.1002/brb3.2694

Cited by 7 publications

(12 citation statements)

References 81 publications

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“… Jones et al (2022a) conducted a similar study to replicate the results of Bisson et al (2020) and van Gelderen et al (2020a) , but also further examined the specific aspects of 3MDR that contribute to its effectiveness. This study included additional secondary outcome variables related to PTSD and a longer follow-up period.…”

Section: Resultsmentioning

confidence: 99%

“…The sample ( N = 11) consisted of Canadian soldiers with TR-PTSD, all but one male. Due to COVID-19 restrictions, control group data were unavailable ( Jones et al, 2022a , p. 5). Nevertheless, participants who completed the 3MDR protocol showed statistically significant improvements in PTSD scores (CAPS-5 and PCL-5), moral injury (MISS-M-SF), depression (PHQ-9), anxiety (GAD-7), emotional regulation (DERS-18), and resilience (CD-RS-25).…”

Section: Resultsmentioning

confidence: 99%

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Virtual realities, real recoveries: exploring the efficacy of 3MDR therapy for treatment-resistant PTSD

Gausemel,

Filkuková

2024

Front. Psychol.

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Exposure-based therapies have shown promise in treating post-traumatic stress disorder (PTSD), but challenges exist in maintaining patient engagement and finding appropriate stimuli for graded exposure. Virtual reality (VR) technology has been used to enhance exposure therapy, but current software lacks customization and some patients remain treatment-resistant. A novel approach called multimodular motion-assisted memory desensitization and reconsolidation (3MDR) has the potential to solve some of the current limitations of VR-assisted exposure therapy. This study examines the efficacy of 3MDR treatment for individuals with treatment-resistant PTSD through a systematic review of relevant literature and clinical studies. Preliminary findings indicate promise for 3MDR in reducing PTSD symptoms, including emotional regulation and moral injury. However, further research with larger samples and controlled studies is needed to understand underlying mechanisms and validate these results. Moreover, this study highlights the importance of health-economic evaluations to assess costs and resource utilization associated with implementing 3MDR treatment in clinical services.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Virtual realities, real recoveries: exploring the efficacy of 3MDR therapy for treatment-resistant PTSD

Gausemel,

Filkuková

2024

Front. Psychol.

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“…Initial 3MDR results, including from three randomized controlled trials, are promising, with significant improvement in PTSD, depression, and anxiety symptoms, including in military populations with treatment-resistant PTSD [ 618 , 762 , 765 - 767 ]. Dropout rates are notably low.…”

Section: Emerging and Novel Approaches To The Treatment Of Ptsdmentioning

confidence: 99%

Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review

Burback

Brémault‐Phillips

Nijdam

et al. 2024

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This narrative state-of-the-art review paper describes the progress in the understanding and treatment of Posttraumatic Stress Disorder (PTSD). Over the last four decades, the scientific landscape has matured, with many interdisciplinary contributions to understanding its diagnosis, etiology, and epidemiology. Advances in genetics, neurobiology, stress pathophysiology, and brain imaging have made it apparent that chronic PTSD is a systemic disorder with high allostatic load. The current state of treatment yields a wide variety of pharmacological and psychotherapeutic approaches, of which many are evidence-based. However, the myriad challenges inherent in the disorder, such as individual and systemic barriers to treatment outcome, comorbidity, emotional dysregulation, suicidality, dissociation, substance use, and trauma-related guilt and shame often render treatment response suboptimal. These challenges are discussed as drivers for emerging novel treatment approaches, including early interventions in the Golden Hours, pharmacological and psychotherapeutic interventions, medication augmentation interventions, the use of psychedelics, as well as interventions targeting the brain and nervous system. All of this aims to improve symptom relief and clinical outcomes. Finally, a phase orientation to treatment is recognized as a tool to strategize treatment of the disorder, and position interventions in step with the progression of the pathophysiology. Revisions to guidelines and systems of care will be needed to incorporate innovative treatments as evidence emerges and they become mainstream. This generation is well-positioned to address the devastating and often chronic disabling impact of traumatic stress events through holistic, cutting-edge clinical efforts and interdisciplinary research.

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“…3MDR therefore comprises multiple moving parts (literally, given the use of a treadmill on which the person with trauma walks) which, delivered by therapists and received by patients interacting together in particular contexts, are thought to trigger cognitive and emotional change. However, whilst it benefits from a theoretical base and emerging empirical evidence of its effectiveness [ 18 – 20 ], the combination and sequencing of critical ingredients that result in 3MDR being (or not being) a beneficial therapy are not self-evident. In this context, in their systematic review of factors associated with outcomes of psychological therapies for people with PTSD, Barawi et al [ 5 ] make a case for greater research attention to be paid to the full range of personal, clinical, social, economic and contextual factors with a possible bearing on patient response.…”

Section: Building a Theoretical Model: 3mdr As A Complex Intervention...mentioning

confidence: 99%

Factors associated with the outcomes of a novel virtual reality therapy for military veterans with PTSD: Theory development using a mixed methods analysis

et al. 2023

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Background Multi-modular motion-assisted memory desensitization and reconsolidation therapy (3MDR) is a new psychological intervention for people with post-traumatic stress disorder (PTSD). 3MDR is immersive, delivered in a virtual reality environment, and emphasises engagement, recollection and reprocessing. Objective Through a theory-driven examination of data relating to 10 out of 42 UK military veterans taking part in a trial of 3MDR, the principal objective was to explore the complex interrelationships between people, interventions and context and to investigate how factors within these domains interacted in specific outcome typologies. Method Quantitative and qualitative data relating to 10 trial participants were derived from: researcher-assessed and self-report clinical measures; interviews; physiological recordings; words describing thoughts and feelings during therapy; and subjective unit of distress scores. Using a convergent mixed methods approach, data were tabulated using a person, intervention and context model. Participant summaries were grouped into outcome typologies, followed by an analysis of data convergence and divergence within each and an interpretation of identified patterns. Results Three outcome response typologies were identified: dramatic improvement, moderate improvement and minimal improvement. Within the person domain, factors associated with outcomes included walking capacity, commitment and ability to complete therapy, and levels of subjective distress. Within the intervention domain, factors associated with outcomes related to image selection and use, therapeutic alliance and orientations towards the tailoring of sessions. Within the context domain, factors associated with outcomes included reactions to the therapy environment. The patterning of secondary outcomes broadly corresponded with primary outcomes within each typology. Alongside patterned data differentiating aspects of the person, intervention and context domains, within the three response typologies data also existed where no obvious patterning was detected. Conclusions The model developed here may have novel value in evaluating a range of personalised interventions, but further work is needed before confident assertions can be made of who is likely to benefit from 3MDR specifically.

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Quantitative changes in mental health measures with 3MDR treatment for Canadian military members and veterans

Cited by 7 publications

References 81 publications

Virtual realities, real recoveries: exploring the efficacy of 3MDR therapy for treatment-resistant PTSD

Virtual realities, real recoveries: exploring the efficacy of 3MDR therapy for treatment-resistant PTSD

Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review

Factors associated with the outcomes of a novel virtual reality therapy for military veterans with PTSD: Theory development using a mixed methods analysis

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