Quantitative Chemical Analysis of Chrysotile Fibrils in Rat Lung Tissue by Analytical Electron Microscopy

Kohyama, Norihiko; Kawai, Kunihiro; Aita, Saburo; Suzuki, Mikio; Hayashi, Hisato

doi:10.2486/indhealth.15.159

Cited by 9 publications

(2 citation statements)

References 2 publications

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“…Publications over the last 5 years (2) have convincingly demonstrated the primary importance of fiber geometry on the carcinogenic effect. However, this does not exclude chemical properties as well as chemical reactivity of such fibers from being of considerable pathogenic importance (3)(4)(5) position. The chemistry of fibers (e.g., chemical com-position and physicochemical properties of the fiber surface, specific surface, porosity, electric charge, crystal surface structure structure, etc.)…”

Section: Introductionmentioning

confidence: 99%

Measurement and analysis of chemically changed mineral fibers after experiments in vitro and in vivo.

Spurný¹

1983

Environ Health Perspect

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Asbestos, as well as other natural and man-made mineral fibers used for in vitro and in vivo experiments, must be described and defined physically and chemically as exactly as possible before any application. The interactions of fibers with the physical, chemical (air, water, etc.) and biological (cells, tissues, etc.) environments cause important changes in fiber chemistry and crystalline structure. Also, these should be detected as precisely as possible after each experiment.Our recent investigations dealt with the development of a complex analytical system for such measurements and with some applications of these analytical procedures for fibrous material sampled in the environment and from biological materials.Chemical and physical microanalyses of asbestos and glass fibers obtained by environmental sampling (air, water) and from human and animal tissue have shown chemical and crystalline changes in these particles. Scanning electron microscopy, electron microprobe analysis and mass spectrometry analysis were used in these investigations. A partial or total leakage of elements could be observed. The leakage of elements in fibers is of a statistical nature. Some fibers remained chemically unchanged; in some fibers some elements were partially leached; and in some fibers the majority of metallic elements were leached. The potential meaning of this effect is also discussed.

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Section: Introductionmentioning

confidence: 99%

Measurement and analysis of chemically changed mineral fibers after experiments in vitro and in vivo.

Spurný¹

1983

Environ Health Perspect

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“…Because of the hypothesis that the toxicity of the asbestos fibers is correlated with the adsorption power of pollutants (3)(4)(5)(6), the intention of this paper is to characterize the surface of asbestos. Therefore, organic impurities were adsorbed onto the asbestos surface by using a gas adsorption process (7) or through equilibration of the fibers with a benzene or water solution.…”

mentioning

confidence: 99%

Laser microprobe mass analysis of asbestos fiber surfaces for organic compounds

Waele¹,

Vansant²,

Espen³

et al. 1983

Anal. Chem.

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Laser microprobe mass analysis was applied for the analysis of organic Impurities at the surface of asbestos fibers. Benzo[a]pyrene was adsorbed from the gas phase and from a benzene solution, benzidine from aqueous solution and N,Ndlmethylanlllne from benzene. By use of laser desorption conditions these compounds, and In the case of N,N-ü\methylanlline Its oxidation products, such as Methyl Violet, could easily be detected.

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Laser microprobe mass analysis (LAMMA) and adsorption study of aliphatic alkylammonium ions and alkylamines on asbestos fibre surfaces

Waele

Verhaert

Vansant

et al. 1983

Surface & Interface Analysis

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The adsorption-desorption behaviour of aliphatic alkylamines for asbestos was studied. A high affinity and strong adsorption characteristics, controlled by Van der Waals interaction and steric hindrance were obtained. For the R.N€I-.CI (1 < n C 4) doped asbestos fibres, the laser microprobe mass analysis (LAMMA) technique was used to analyse selectively the individual asbestos surface loadings. Only for quaternary (and tertiary at higher concentrations) ammonium products, could a semi-quantitative picture of the organic asbestos surface covering be observed.

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Quantitative Chemical Analysis of Chrysotile Fibrils in Rat Lung Tissue by Analytical Electron Microscopy

Cited by 9 publications

References 2 publications

Measurement and analysis of chemically changed mineral fibers after experiments in vitro and in vivo.

Measurement and analysis of chemically changed mineral fibers after experiments in vitro and in vivo.

Laser microprobe mass analysis of asbestos fiber surfaces for organic compounds

Laser microprobe mass analysis (LAMMA) and adsorption study of aliphatic alkylammonium ions and alkylamines on asbestos fibre surfaces

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