Quantitative chemical imaging of breast calcifications in association with neoplastic processes

Shin, Kseniya; Laohajaratsang, Mint; Men, Shuaiqian; Figueroa, Benjamin; Dintzis, Suzanne M.; Fu, Dan

doi:10.7150/thno.43325

Cited by 47 publications

(48 citation statements)

References 46 publications

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“…Copyright 2019, Nature Publishing Group. (B) The combination of protein (C−H stretching) and phosphate image visualize the location of calcification in breast cancer, Adapted with permission [67] . Copyright 2020, Elsevier.…”

Section: Coherent Raman Scatteringmentioning

confidence: 99%

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Raman Imaging: An Impending Approach Towards Cancer Diagnosis

Ramya

Arya

Madhukrishnan

et al. 2021

Chemistry An Asian Journal

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In accordance with the recent studies, Raman spectroscopy is well experimented as a highly sensitive analytical and imaging technique in biomedical research, mainly for various disease diagnosis including cancer. In comparison with other imaging modalities, Raman spectroscopy facilitate numerous assistances owing to its low background signal, immense spatial resolution, high chemical specificity, multiplexing capability, excellent photo stability and non‐invasive detection capability. In cancer diagnosis Raman imaging intervened as a promising investigative tool to provide molecular level information to differentiate the cancerous vs non‐cancerous cells, tissues and even in body fluids. Anciently, spontaneous Raman scattering is very feeble due to its low signal intensity and long acquisition time but new advanced techniques like coherent Raman scattering (CRS) and surface enhanced Raman scattering (SERS) gradually superseded these issues. So, the present review focuses on the recent developments and applications of Raman spectroscopy‐based imaging techniques for cancer diagnosis.

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Section: Coherent Raman Scatteringmentioning

confidence: 99%

“…They combined both SHG and SRS technique to visualize the stomal collagen as well as collagen embedded on the calcification matrix. The carbonate content in calcification was quantified based on the Raman peaks corresponds to carbonate/phosphate ratio (Figure 4B) [67] …”

Section: Coherent Raman Scatteringmentioning

confidence: 99%

Raman Imaging: An Impending Approach Towards Cancer Diagnosis

Ramya

Arya

Madhukrishnan

et al. 2021

Chemistry An Asian Journal

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“…46 Shin et al, demonstrated the clinical value of hyperspectral SRS imaging for breast cancer diagnosis via provision of spatially resolved qualitative and quantitative information on tissue calcification. 47 A broadband femtosecond dual-beam laser system was used to quantify the carbonate content of hydroxyapatite, the main calcification species associated with cancer. The ratio of carbonate (∼1070 cm −1 ) to phosphate (∼960 cm −1 ) peaks mapped the intra-and inter-tissue calcification heterogeneity among breast cancer tissue samples.…”

Section: Imaging In the Fingerprint Regionmentioning

confidence: 99%

Recent advances in the use of stimulated Raman scattering in histopathology

Lee

Herrington

Ravindra

et al. 2021

Analyst

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“…Numerous SRS studies were reported on intraoperative diagnosis of fresh, unprocessed surgical specimens, in particular for brain tumors [53]. Recently, a parallel workflow was presented that combined SRS for histological assessment—also called stimulated Raman histology (SRH)—and deep convolutional neural networks (CNNs) to automatically predict diagnosis at the bedside in near real time [54]. Specifically, over 2.5 million SRH images trained the CNNs that predicted brain tumor diagnosis in the operating room in less than 150 seconds.…”

Section: Spontaneous Surface Enhanced and Coherent Raman Spectroscopymentioning

confidence: 99%

Biophotonic technologies for assessment of breast tumor surgical margins—A review

Balasundaram

Krafft

Zhang

et al. 2020

Journal of Biophotonics

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Breast conserving surgery (BCS) offering similar surgical outcomes as mastectomy while retaining breast cosmesis is becoming increasingly popular for the management of early stage breast cancers. However, its association with reoperation rates of 20% to 40% following incomplete tumor removal warrants the need for a fast and accurate intraoperative surgical margin assessment tool that offers cellular, structural and molecular information of the whole specimen surface to a clinically relevant depth. Biophotonic technologies are evolving to qualify as such an intraoperative tool for clinical assessment of breast cancer surgical margins at the microscopic and macroscopic scale. Herein, we review the current research in the application of biophotonic technologies such as photoacoustic imaging, Raman spectroscopy, multimodal multiphoton imaging, diffuse optical imaging and fluorescence imaging using medically approved dyes for breast cancer detection and/or tumor subtype differentiation toward intraoperative assessment of surgical margins in BCS specimens, and possible challenges in their route to clinical translation.

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Quantitative chemical imaging of breast calcifications in association with neoplastic processes

Cited by 47 publications

References 46 publications

Raman Imaging: An Impending Approach Towards Cancer Diagnosis

Raman Imaging: An Impending Approach Towards Cancer Diagnosis

Recent advances in the use of stimulated Raman scattering in histopathology

Biophotonic technologies for assessment of breast tumor surgical margins—A review

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