Quantitative comparison of two-dimensional and three-dimensional strain measurement using MRI feature tracking in repair Fontan patients and normal child volunteers

Abstract

Background: The accuracy of 2D and 3D strain analyses was evaluated by comparing strain and cardiac function parameters in Fontan repair patients and normal child volunteers. Methods: We retrospectively enrolled 32 patients with Fontan circulation and 32 child volunteers who had undergone clinical cardiac magnetic resonance (CMR) assessment of the dominant ventricle with a 1.5-Tesla MRI scanner. Global and regional strain (2D and 3D) of the dominant ventricle in both groups was assessed using CMR feature-tracking. Correlations between cardiac function and strain data were assessed using Pearson's correlation coefficient values. The intraclass correlation coefficient (ICC) and coefficient of variation (CoV) were determined to evaluate repeatability and agreement. Results: The 2D GLS showed significant differences between the Fontan repair patients and volunteers (− 16.49 ± 5.00 vs.-19.49 ± 2.03; p = 0.002). The 2D GRS and 2D GCS showed no significant differences between two groups. 2D GRS: 38.96 ± 14.48 vs. 37.46 ± 7.77; 2D GCS: − 17.64 ± 5.00 vs.-16.89 ± 2.96, respectively; p > 0.05). The 3D global radial strain (GRS), global circumferential strain (GCS), and global longitudinal strain (GLS) showed significant differences between the Fontan repair patients and volunteers (3D GRS: 36.35 ± 16.72 vs. 44.96 ± 9.98; 3D GLS: − 8.86 ± 6.84 vs.-13.67 ± 2.44; 3D GCS: − 13.70 ± 7.84 vs.-18.01 ± 1.78; p < 0.05, respectively). The ejection fraction (EF) and 3D GCS were significantly associated (r = − 0.491, p = 0.004). The 3D GCS showed correlations with the indexed end-diastolic volume (EDV) (r = 0.523, p = 0.002) and indexed end-systolic volume (ESV) (r = 0.602, p < 0.001). 3D strain showed good reproducibility, with GCS showing the best inter-observer agreement (ICC = 0.87 and CoV = 5.15), followed by GLS (ICC = 0.84 and CoV = 5.36). Conclusions: 3D GCS is feasible, highly reproducible, and strongly correlated with conventional cardiac function measures. 3D GCS assessments may be useful for monitoring abnormal myocardial motion in patients with Fontan circulation.

Left ventricular myocardial strain quantification with two- and three-dimensional cardiovascular magnetic resonance based tissue tracking

“…The algorithms used in CVI 42 2D and 3D strain analysis have been discussed by Liu and Hu et al (17,18) before. Briefly, 2D CMR-TT determines the myocardial deformation by a set of reference points placed on the mid myocardial wall, which are tracked over the cardiac cycle in the short-axis or long-axis cine images.…”

Papel de la ecocardiografía <i>speckle-tracking</i> (rastreo de marcas) y la resonancia magnética cardíaca-<i>feature tracking</i> en la circulación de Fontan. Diferencias entre los ventrículos derecho e izquierdo

“…El gradiente basal-apical creciente observado en este análisis regional se mantuvo en ambas morfologías con valores significativamente menores en VU derechos. También Hu, et al 31 describieron hallazgos similares y los relacionaron con la alteración del loop cardíaco y la ausencia de fibras helicoidales en estos pacientes [33][34][35] .…”