Quantitative Contrast-Enhanced Ultrasound Parameters in Crohn Disease: Their Role in Disease Activity Determination With Ultrasound

Medellin-Kowalewski, Alexandra; Wilkens, Rune; Wilson, Aze; Ruan, Ji; Wilson, Stephanie R.

doi:10.2214/ajr.15.14506

Cited by 58 publications

(60 citation statements)

References 57 publications

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“…Recently, it was demonstrated that quantitative CEUS parameters integrated into inflammatory assessments by established grey-scale US with colour Doppler imaging reduce indeterminate results and improve CD activity level determinations [77].…”

Section: Ceusmentioning

confidence: 99%

SICUS and CEUS imaging in Crohn’s disease: an update

et al. 2017

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Endoscopy remains the main technique in the diagnosis and treatment of Crohn's disease (CD); nevertheless, the recent development of innovative and non-invasive imaging techniques has led to a new tool in the exploration of small bowel in CD patients. This paper reviews the available data on ultrasound imaging used for the evaluation of CD, highlighting the role of small intestine contrast-enhanced ultrasonography with the use of oral and intravenous contrast agents.Keywords Crohn's disease Á Contrast-enhanced ultrasound Á Small intestine contrast ultrasonography Sommario Nell'iter diagnostico e terapeutico della malattia di Crohn l'endoscopia rappresenta la principale metodica strumentale. Tuttavia, la recente introduzione di tecniche di imaging innovative e non invasive ha implementato lo studio dell'intestino nelle malattie infiammatorie croniche intestinali. La seguente revisione raccoglie i dati disponibili in letteratura relativi all'utilizzo dell'ecografia con mezzo di contrasto, sia orale (SICUS) sia endovenoso (CEUS), nella valutazione dei pazienti affetti da malattia di Crohn.

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Section: Ceusmentioning

confidence: 99%

SICUS and CEUS imaging in Crohn’s disease: an update

et al. 2017

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“…However there are increasing reports describing the utility of qualitative evaluation of bowel wall vascularity patterns in CD using CEUS [80, 81], as well as software defined quantitative metrics from time-intensity curves such as time-to-peak, peak enhancement and area under the curve [82–85]. Promising data for evaluation of CD activity against an endoscopic reference have been reported [84, 86], as well as utility in stricture characterisation [87], detection of postoperative recurrence [88], and treatment response evaluation [89].…”

Section: Discussionmentioning

confidence: 99%

“…Promising data for evaluation of CD activity against an endoscopic reference have been reported [84, 86], as well as utility in stricture characterisation [87], detection of postoperative recurrence [88], and treatment response evaluation [89]. Apparent diagnostic benefit over conventional US parameters is also described [85] .…”

Section: Discussionmentioning

confidence: 99%

The first joint ESGAR/ ESPR consensus statement on the technical performance of cross-sectional small bowel and colonic imaging

et al. 2016

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ObjectivesTo develop guidelines describing a standardised approach to patient preparation and acquisition protocols for magnetic resonance imaging (MRI), computed tomography (CT) and ultrasound (US) of the small bowel and colon, with an emphasis on imaging inflammatory bowel disease.MethodsAn expert consensus committee of 13 members from the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Paediatric Radiology (ESPR) undertook a six-stage modified Delphi process, including a detailed literature review, to create a series of consensus statements concerning patient preparation, imaging hardware and image acquisition protocols.ResultsOne hundred and fifty-seven statements were scored for agreement by the panel of which 129 statements (82 %) achieved immediate consensus with a further 19 (12 %) achieving consensus after appropriate modification. Nine (6 %) statements were rejected as consensus could not be reached.ConclusionsThese expert consensus recommendations can be used to help guide cross-sectional radiological practice for imaging the small bowel and colon.Key points• Cross-sectional imaging is increasingly used to evaluate the bowel • Image quality is paramount to achieving high diagnostic accuracy • Guidelines concerning patient preparation and image acquisition protocols are provided

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“… It has been found that disease activity correlates with increased vascularity . Color Doppler imaging is an important technique that has traditionally been used to detect vascular signals from blood vessels in the bowel wall as a qualitative measure of active inflammation . Bowel intramural angiogenesis and inflammation have also been well shown on CT and MRI and confirmed by histologic analysis .…”

Section: Bowel With Ibdmentioning

confidence: 99%

“…The grading of the classic grayscale parameters of bowel wall thickness, color Doppler signal, and perienteric inflammatory fat allows us to generate an overall assessment of disease activity using a USGA (Table ) . Lymphadenopathy is not included in the USGA.…”

Section: Overall Bowel Disease Grading: Usgamentioning

confidence: 99%

Bowel Ultrasound State of the Art: Grayscale and Doppler Ultrasound, Contrast Enhancement, and Elastography in Crohn Disease

Merrill

Medellin

et al. 2019

J of Ultrasound Medicine

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Bowel ultrasound (US) is accurate for assessing bowel inflammation and complications in Crohn disease. Additionally, contrast‐enhanced US provides a quantitative, objective measurement of inflammatory activity in inflammatory bowel disease, and shear wave elastography predicts the stiffness of bowel, an increase of which suggests less response to medical therapy, often necessitating surgery. Overall, bowel US is an excellent, safe, and repeatable choice for routine surveillance and for urgent imaging. We describe an approach to evaluating inflammatory bowel disease and review its features on standard grayscale US with Doppler imaging and show how contrast‐enhanced US and shear wave elastography can distinguish between inflammatory and fibrostenotic bowel.

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Quantitative Contrast-Enhanced Ultrasound Parameters in Crohn Disease: Their Role in Disease Activity Determination With Ultrasound

Abstract: Quantitative CEUS parameters integrated into inflammatory assessments with ultrasound reduce indeterminate results and improve disease activity level determinations.

Cited by 58 publications

References 57 publications

SICUS and CEUS imaging in Crohn’s disease: an update

SICUS and CEUS imaging in Crohn’s disease: an update

The first joint ESGAR/ ESPR consensus statement on the technical performance of cross-sectional small bowel and colonic imaging

Bowel Ultrasound State of the Art: Grayscale and Doppler Ultrasound, Contrast Enhancement, and Elastography in Crohn Disease

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