Quantitative detection of THz-ATR spectra of aqueous samples under strong-field terahertz wave

Shi, Wei; Li, Chunhui; Wang, Haiqing; Wang, Zhiquan; Yang, Lei

doi:10.1016/j.isci.2022.105871

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Technological advances in material sciences and microfabrication and device technologies in the last decade have facilitated the development of powerful sources, uncooled detectors and advanced imaging techniques, along with an extended scope for flexible electronics; biomedical, highfrequency sensing (particularly promising); and communication devices [42][43][44]. A few of the remarkable advancements in recent times leading the prospective application of THz in biomedical spectroscopy include [45,46]: THz wound and diabetic injury screening [47]; spectroscopy and imaging for cancer diagnosis [48][49][50]; a THz time-domain spectral (THz-TDS) system for biological macromolecule detection [51]; biomolecular and pathogen detection [52] and evaluation of transdermal drug delivery [53]; identification of tumor mutation in the central nervous system [54,55]; and intraoperative neurodiagnostics [56]. Further advancement in THz biophotonics, materials and instrumentation [57][58][59]; tissue imaging techniques [60][61][62]; and applied computing algorithms [63] may also open up newer frontiers in THz biomedical applications.…”

Section: Prospect Of Terahertz Biomedical Spectroscopymentioning

confidence: 99%

Terahertz Radiation from High Electron Mobility Avalanche Transit Time Sources Prospective for Biomedical Spectroscopy

et al. 2023

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A Schottky barrier high-electron-mobility avalanche transit time (HEM-ATT) structure is proposed for terahertz (THz) wave generation. The structure is laterally oriented and based on AlGaN/GaN two-dimensional electron gas (2-DEG). Trenches are introduced at different positions of the top AlGaN barrier layer for realizing different sheet carrier density profiles at the 2-DEG channel; the resulting devices are equivalent to high–low, low–high and low-high–low quasi-Read structures. The DC, large-signal and noise simulations of the HEM-ATTs were carried out using the Silvaco ATLAS platform, non-sinusoidal-voltage-excited large-signal and double-iterative field-maximum small-signal simulation models, respectively. The breakdown voltages of the devices estimated via simulation were validated by using experimental measurements; they were found to be around 17–18 V. Under large-signal conditions, the series resistance of the device is estimated to be around 20 Ω. The large-signal simulation shows that the HEM-ATT source is capable of delivering nearly 300 mW of continuous-wave peak power with 11% conversion efficiency at 1.0 THz, which is a significant improvement over the achievable THz power output and efficiency from the conventional vertical GaN double-drift region (DDR) IMPATT THz source. The noise performance of the THz source was found to be significantly improved by using the quasi-Read HEM-ATT structures compared to the conventional vertical Schottky barrier IMPATT structure. These devices are compatible with the state-of-the-art medium-scale semiconductor device fabrication processes, with scope for further miniaturization, and may have significant potential for application in compact biomedical spectroscopy systems as THz solid-state sources.

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Section: Prospect Of Terahertz Biomedical Spectroscopymentioning

confidence: 99%

Terahertz Radiation from High Electron Mobility Avalanche Transit Time Sources Prospective for Biomedical Spectroscopy

et al. 2023

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“…They possess remarkable penetrating abilities, particularly for opaque materials like polymers, paper, woven and non-woven fabric, ceramics, and similar non-metallic substances, enabling non-contact detection [1][2][3][4]. Because terahertz radiation is non-ionizing and has a low photon energy, materials and biomolecules are unaffected by it, thereby suitable for nondestructive testing purposes [5][6][7]. Their higher frequencies compared to microwaves allow for utilization in diverse scenarios, including those requiring high-speed communications and large bandwidth, such as terahertz antennas and radars [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

A highly sensitive narrowband metasurface absorber in the terahertz regime for early detection of cancer cells

Ali,

Javed,

Mahmood

et al. 2024

Biophotonics in Point-of-Care III

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Terahertz (THz) technology, particularly THz plasmonics for sensing applications, has gathered substantial interest across various research domains. Metamaterials (MM), artificially designed structures operating at subwavelength scales, offer a solution to enhance the sensitivity of free-space THz detection. Lung cancer, a pervasive and life-threatening disease globally, contributes significantly to cancer-related mortality due to challenges in early diagnosis and the burden of expensive detection methods. Brain cancer, with its considerable heterogeneity and high fatality rates, primarily afflicts children and adolescents. In response to these critical issues, we propose an innovative, cost-effective, and label-free strategy for the rapid discrimination of lung and brain cancer cells, employing THz metamaterial absorbers. This research employs a polarization-insensitive THz narrowband metamaterial absorber (MMA) operating at 4.3 THz, featuring quartz as a substrate and gold as a ring resonator. Simulation outcomes demonstrate that the absorption spectrum peak shifts when the sensor interacts with analytes of varying refractive indices and thicknesses. Covering the sensor with 0.16 μm thick non-destructive analytes yields an impressive sensitivity of up to 68 GHz/RIU. We conducted numerical simulations, exploring variations in analyte thickness, quantity, and refractive index. The results confirm that sensitivity intensifies around the edges of the ring resonator and analyte concentration near it, underscoring the significant influence of field enhancement in the surrounding region. This innovative detection approach promises substantial cost reductions through reusability, offering great potential in the field of cancer detection, enabling differentiation between cancer types, and identifying primary lesions and metastatic cancers.

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Design and Simulation of THz Metasurface Sensor Based on Transmission and Reflection Modes for Aqueous Solution Detection

Zhang,

et al. 2024

Plasmonics

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Quantitative detection of THz-ATR spectra of aqueous samples under strong-field terahertz wave

Cited by 7 publications

References 20 publications

Terahertz Radiation from High Electron Mobility Avalanche Transit Time Sources Prospective for Biomedical Spectroscopy

Terahertz Radiation from High Electron Mobility Avalanche Transit Time Sources Prospective for Biomedical Spectroscopy

A highly sensitive narrowband metasurface absorber in the terahertz regime for early detection of cancer cells

Design and Simulation of THz Metasurface Sensor Based on Transmission and Reflection Modes for Aqueous Solution Detection

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