Quantitative Determination of Drugs by using Chloramine-T and Methyl orange Couple: A spectrophotometric study

Sasikala, M.; Sayanna, K.; Venkateshwarlu, G.

doi:10.5958/0974-4150.2015.00021.8

Cited by 2 publications

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“…Analytical procedures previously published in the literature were scanned to determine the amount of TSD in bulk and pharmaceutical dosage forms and biological fluids. Spectrophotometric [19][20][21][22][23][24][25][26], voltammetric [27], capillary electrophoresis [28], high-performance liquid chromatographic [29][30][31][32][33][34][35][36][37][38][39][40], liquid chromatographic coupled with tandem mass spectrometry (LC-MS/MS) [40,41], thermal [42], and high-performance thin-layer chromatography [43][44][45][46] methods were reported for determination of TSD in bulk and pharmaceutical dosage forms and biological fluids were developed.…”

Section: Introductionmentioning

confidence: 99%

A green HPLC method for the determination of torasemide in pharmaceutical dosage forms: Development, validation, and greenness assessment

Akbel,

Bulduk,

Gökçe

2023

Bull. Chem. Soc. Eth.

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Two HPLC methods were developed for the determination of torasemide in pharmaceutical products. In the first method, a C18 column whose temperature was kept constant at 25 °C was used. A combination of 0.1% formic acid solution in water and acetonitrile (50/50, v/v) was used as the mobile phase, and isocratic elution was performed at a flow rate of 1.0 mL min-1. Detection was carried out at 288 nm using the UV detector. Although all other conditions are the same as in the first method, the only difference in the second method is that ethanol is used instead of acetonitrile as the organic modifier in the mobile phase. HPLC methods were validated in accordance with ICH guidelines. Correlation coefficients were greater than 0.999 in the concentration range of 5-30 mg mL-1. Later, HPLC methods were applied to pharmaceutical formulations. Results were compared using the student (t) test for means and the Fischer (F) test for standard deviations. No significant differences were observed between methods. Additionally, a greenness evaluation of the developed methods was carried out using AGREE software. As a result, the latter method was proposed as an excellent eco-friendly alternative for the determination of torasemide in pharmaceuticals. KEY WORDS: Green HPLC, Analytical method, Torasemide, Pharmaceuticals Bull. Chem. Soc. Ethiop. 2024, 38(1), 11-25. DOI: https://dx.doi.org/10.4314/bcse.v38i1.2

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Section: Introductionmentioning

confidence: 99%

A green HPLC method for the determination of torasemide in pharmaceutical dosage forms: Development, validation, and greenness assessment

Akbel,

Bulduk,

Gökçe

2023

Bull. Chem. Soc. Eth.

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Extractive Spectrophotometric Determination of Meropenem in Pharmaceutical Formulations

Rao Narala,

Saraswathi

2023

RJPT

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A simple, sensitive extractive spectrophotometric method for the determination of Meropenem has been proposed. The method is based on the formation of an ion-association complex between the drug and acidic dye methyl orange, which was a pale yellow colored chromogen extracted with dichloro methane from the aqueous phase, measured at 400 nm. The Beer’s law was obeyed in the concentration range of 10 - 30 µg/ml. Thus results of the proposed method was validated statistically and applied successfully to the determination of Meropenem in bulk and its dosage forms.

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Quantitative Determination of Drugs by using Chloramine-T and Methyl orange Couple: A spectrophotometric study

Cited by 2 publications

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A green HPLC method for the determination of torasemide in pharmaceutical dosage forms: Development, validation, and greenness assessment

A green HPLC method for the determination of torasemide in pharmaceutical dosage forms: Development, validation, and greenness assessment

Extractive Spectrophotometric Determination of Meropenem in Pharmaceutical Formulations

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