2007
DOI: 10.12973/ejac/78053
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Quantitative Determination of Levofloxacin and Ambroxol Hydrochloride in Pharmaceutical Dosage Form by Reversed-Phase High Performance Liquid Chromatography

Abstract: The objective of this present work was to develop and validate analytical method for quantitative determination of Levofloxacin and Ambroxol hydrochloride in a new tablet formulation. Chromatographic separation of the two drugs were analyzed on a Hypersil BDS C18 column (25cm X 4.6mm, 5µm). The mobile phase constituted of Buffer: Acetonitirile: Methanol (650:250:100) with triethylamine and pH adjusted to 5.2 with dilute orthophosphoric acid was delivered at the flow rate 1.0 mL min -1 . Detection was performed… Show more

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Cited by 19 publications
(14 citation statements)
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“…In the case of tablets, these are individually weighed and pulverized to obtain a homogeneous mixture and an appropriate amount of the resultant powder is thereafter dissolved in a selected solvent and sonicated to facilitate solubilisation. Finally, each sample is filtered through a suitable filter and injected into the chromatographic system [58,73,[128][129][130][131]. For eye drops and injectable solutions, dilution is the only procedure that is performed [58,73,129].…”
Section: Sample Preparationmentioning
confidence: 99%
“…In the case of tablets, these are individually weighed and pulverized to obtain a homogeneous mixture and an appropriate amount of the resultant powder is thereafter dissolved in a selected solvent and sonicated to facilitate solubilisation. Finally, each sample is filtered through a suitable filter and injected into the chromatographic system [58,73,[128][129][130][131]. For eye drops and injectable solutions, dilution is the only procedure that is performed [58,73,129].…”
Section: Sample Preparationmentioning
confidence: 99%
“…The linearity, LOD and LOQ values of LFX and ABX obtained from UV method have been compared with the reported method. 29 The data displayed in Table 3, indicates high sensitivity of the UV method over reported one.…”
Section: Lod =mentioning
confidence: 89%
“…Some analytical methods have been reported for the determination of LCD either alone [6][7][8][9] or in combination with other drugs using high performance liquid chromatography [10][11][12][13][14][15], thin layer chromatography [16] and UV spectrophotometry [17][18][19][20][21][22]. As well, a number of methods have been reported for the individual determination of ABH [23][24][25][26][27], and in combination with other drugs in pharmaceutical dosage form by high performance liquid chromatography [28][29][30][31][32][33], liquid chromatography-mass spectroscopy/mass spectroscopy [34], thin layer chromatography [35], UV spectrophotometry [36,37] and high performance thin layer chromatography [38,39].…”
Section: Introductionmentioning
confidence: 99%