Quantitative Determinations of Codeine Phosphate, Guaifenesin, Pheniramine Maleate, Phenylpropanolamine Hydrochloride, and Pyrilamine Maleate in an Expectorant by High-Pressure Liquid Chromatography

Development and validation of a UV-spectrophotometric method for the determination of pheniramine maleate and its stability studies

“…A stability-indicating UVspectrophotometric method was developed and validated for the determination of PAM in bulk drug and in tablets. The method is superior to many reported non-spectrophotometric procedures [6][7][8][9][10][11][12][13][14][15][16][17] in terms of the simplicity, methodology, ease of analysis, sensitivity, and cost-effectiveness. The reported spectrophotometric methods [18,19] require critical pH control [19] or the tedious and time-consuming liquid-liquid extraction where losses of the analyte are unavoidable due to incomplete recovery from the aqueous phase.…”

“…Several techniques such as HPLC [6][7][8][9][10][11][12], thin layer chromatography-densitometry [13], gas-liquid chromatogra-phy [14], capillary zone electrophoresis [15], capillary isotachophoresis [16], and polarography [17] have been reported for the determination of PAM in pharmaceuticals, including bulk drug, tablets, injections, expectorants, syrups, and nasal sprays.…”

Simultaneous, stability indicating, HPLC-DAD determination of guaifenesin and methyl and propyl-parabens in cough syrup

“…in solid and liquid formulations [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Moreover some of these methods showed quantitative determination of the preservative sodium benzoate [2,3,7,[9][10][11].…”

Determination of Amine Ingredients in Cough-Cold Liquids by Reversed-Phase Ion-Pair High-Performance Liquid Chromatography

“…This situation is undesirable, since excipient interferences are likely to arise when different formulations from a variety of sources are analyzed. The determination of codeine, phenylpropanolamine, pheniramine, and pyrilamine has also been described (10). This procedure fails to separate the two antihistamines, pheniramine and pyrilamine, and they must be quantitated separately by a spectrophotometric method.…”