Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis

Sage, Caroline; Peeters, Ronald; Görner, Astrid; Robberecht, Wim; Sunaert, Stefan

doi:10.1016/j.neuroimage.2006.09.025

Cited by 183 publications

(179 citation statements)

References 52 publications

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…Diffusion abnormalities of the corticospinal tract have been reported in a variety of conditions including stroke, amyotrophic lateral sclerosis and congenital hemiparesis [16,17,18]. We have recently reported abnormal FA and ADC values, probably reflecting Wallerian degeneration, in the distal parts of the affected cortico-spinal tract in children who had undergone hemispherectomy.…”

Section: Discussionmentioning

confidence: 72%

The corticospinal tract in Sturge–Weber syndrome: A diffusion tensor tractography study

Sivaswamy¹,

Rajamani²,

Juhász³

et al. 2008

Brain and Development

View full text Add to dashboard Cite

OBJECTIVE-To utilize diffusion tensor tractography and evaluate the integrity of the corticospinal tract in children with unilateral Sturge-Weber syndrome (SWS).METHODS-Sixteen children (age: 1.5-12.3 years) with SWS involving one hemisphere and varying degrees of motor deficit, underwent magnetic resonance imaging (MRI) as part of a prospective clinical research study. Diffusion tensor imaging (DTI) was obtained and fiber tracking of the corticospinal tract was performed yielding average FA and ADC values along the pathway. These values were compared between the two hemispheres (affected vs. unaffected) and also correlated with the degree of motor deficits, after correction for age.RESULTS-Cortico-spinal tract FA values on the side of the affected hemisphere were lower (p=0.008) and ADC values were higher (p=0.011) compared to the normal side. Furthermore, FA and ADC values on the side of the angioma did not show the normal age-related variations, which the contralateral corticospinal pathway values did demonstrate. Although none of the patients had severe hemipares, those with moderate motor deficit had increased ADC values, as compared to those with mild (p= 0.009) or no motor deficit (p= 0.045).CONCLUSION-MRI with DTI shows abnormalities of the corticospinal tract in children with SWS even before severe motor impairment develops. Thus, DTI can be a clinically useful method to evaluate the integrity of the corticospinal tract in young children who are at risk for progressive motor dysfunction.

show abstract

Section: Discussionmentioning

confidence: 72%

The corticospinal tract in Sturge–Weber syndrome: A diffusion tensor tractography study

Sivaswamy¹,

Rajamani²,

Juhász³

et al. 2008

Brain and Development

View full text Add to dashboard Cite

show abstract

“…8,9 Significant correlations of diffusion parameters with duration, progression, and severity of the disease also have been reported in some previous studies. 2,[9][10][11][12] Even if the clinical signs of ALS consist of motor impairments, recent evidence suggests that ALS is not an isolated motor neuron disorder 13 and that the variability in the location and extension of FA reduction in patients with ALS is such that relying on a priori ROIs to assess DTI changes may not give a consistent and complete picture of ALS neurodegeneration. Therefore, a novel approach based on whole-brain DTI analysis may result in improved accuracy in detecting subclinical microstructural disease-related WM changes.…”

mentioning

confidence: 99%

Widespread Microstructural White Matter Involvement in Amyotrophic Lateral Sclerosis: A Whole-Brain DTI Study

Cirillo¹,

Esposito²,

Tedeschi³

et al. 2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:The extensive application of advanced MR imaging techniques to the study of ALS has undoubtedly improved our knowledge of disease pathophysiology, even if the actual spread of the neurodegenerative process throughout the central nervous system is not fully understood. The present study aimed to detect WM patterns of microstructural abnormalities to better investigate the pathologic process in ALS, within but also beyond CSTs, in a whole-brain analysis.

show abstract

“…The most common finding is a reduction of FA in the CST, which is thought to be due to the neuronal degeneration of UMN. Increased MD along the CST has been reported by some investigators [9,12,45,46]; however, no such changes were observed in another study [10]. In one of these studies, Sage et al [45] spatially interpolated FA and MD over the course of CST.…”

Section: Clinical Applicationmentioning

confidence: 93%

“…Voxel-based analysis of DTI data has been used to evaluate the WM integrity in ALS [11,45,46]. Recently, a hybrid approach, known as tract-based spatial statistics (TBSS) [47], which attempts to combine the best of voxel-based and tract-based analyses is being increasingly used in ALS [48,49].…”

Section: Clinical Applicationmentioning

confidence: 99%

“…A significant advantage of the TBSS approach is that it allows statistical changes to be projected on the skeleton of WM structures. Several studies have reported a significant reduction of FA not only in the CST but also in extramotor regions, including the corpus callosum, frontal and parietal WM as well as the hippocampal formation and insula [36,45,48,49]. Using a different methodology, Agosta et al [50] recently reported increased axial diffusivity of the uncinate fasciculus in ALS patients and suggested that uncinate fasciculus involvement may be related to the behavioral symptoms of patients with ALS.…”

Section: Clinical Applicationmentioning

confidence: 99%

See 1 more Smart Citation

Neuroimaging in Amyotrophic Lateral Sclerosis

et al. 2011

View full text Add to dashboard Cite

Summary: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of upper motor neurons (UMN) and lower motor neurons (LMN). While LMN dysfunction can be confirmed by electromyography (EMG) and muscle biopsy, UMN involvement is more difficult to detect, particularly in the early phase. Objective and sensitive measures of UMN dysfunction are needed for early diagnosis and monitoring of disease progression and therapeutic efficacy. Advanced magnetic resonance imaging (MRI) techniques, such as diffusion, perfusion, magnetization transfer imaging, functional MRI, and MR spectroscopy, provide insight into the pathophysiological processes of ALS and may have a role in the identification and monitoring of UMN pathology. This article provides an overview of these neuroimaging techniques and their potential roles in ALS.

show abstract

Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis

Cited by 183 publications

References 52 publications

The corticospinal tract in Sturge–Weber syndrome: A diffusion tensor tractography study

The corticospinal tract in Sturge–Weber syndrome: A diffusion tensor tractography study

Widespread Microstructural White Matter Involvement in Amyotrophic Lateral Sclerosis: A Whole-Brain DTI Study

Neuroimaging in Amyotrophic Lateral Sclerosis

Contact Info

Product

Resources

About