Quantitative EEG Effects and Drug Plasma Concentration of Phenobarbital, 50 and 100 mg Single-Dose Oral Administration to Healthy Volunteers: Evidence of Early CNS Bioavailability

Sannita, Walter G.; Balbi, Alessandro; Gìacchino, Fulvio; Rosadini, G

doi:10.1159/000119453

Cited by 10 publications

(3 citation statements)

References 20 publications

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“…Another important limitation of our study was that only one concentration of N 2 O was tested. All patients were premedicated with phenobarbital, which may have an indeterminate effect on baseline EEG, and itself has an isoelectric effect when used at high doses . However, both control and test groups received this medication.…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane‐induced isoelectricEEGand burst suppression: differential and antagonistic effect of added nitrous oxide

et al. 2017

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SummaryThe objective of this study was to investigate whether nitrous oxide influenced the ED50 of sevoflurane for induction of isoelectric electroencephalogram (ED50isoelectric) differently from its influence on the ED50 of sevoflurane for electroencephalogram burst suppression (ED50burst). In a prospective, randomised, double‐blind, parallel group, up–down sequential allocation study, 77 ASA physical status 1 and 2 patients received sevoflurane induction and, after tracheal intubation, were randomly allocated to receive sevoflurane with either 40% oxygen in air (control group) or 60% nitrous oxide in oxygen mixture (nitrous group). The ED50isoelectric in the two groups was determined using Dixon's up and down method, starting at 2.5% with 0.2% step size of end‐tidal sevoflurane. The electroencephalogram was considered as isoelectric when a burst suppression ratio of 100% lasted > 1 min. The subsequent concentrations of sevoflurane administered were determined by the presence or absence of isoelectric electroencephalogram in the previous patient in the same group. The ED50isoelectric in the nitrous group 4.08 (95%CI, 3.95–4.38)% was significantly higher than that in the control group 3.68 (95%CI, 3.50–3.78)% (p < 0.0001). The values for ED50burst were 3.05 (95%CI, 2.66–3.90)% and 3.02 (95%CI, 3.00–3.05)% in nitrous group and control group, respectively (p = 0.52). The addition of 60% nitrous oxide increases ED50isoelectric, but not the ED50burst of sevoflurane. Neither result indicates an additive effect of anaesthetic agents, as might be expected, and possible reasons for this are discussed.

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Section: Discussionmentioning

confidence: 99%

Sevoflurane‐induced isoelectricEEGand burst suppression: differential and antagonistic effect of added nitrous oxide

et al. 2017

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“…There are many reports about the effect of EEG influenced by AEDs using linear method. 1,11 –22…”

Section: Discussionmentioning

confidence: 99%

“…All these processes related to each other and can add to the individual variability in response to the drug action. 15 The complexity of EEG was influenced by the state of the subject, emotion and technical parameters. 26 –29 Therefore, it is difficult to determine how topiramate induced the change of EEG complexity.…”

Section: Discussionmentioning

confidence: 99%

The Lyapunov Exponent of the EEG after Administration of Topiramate

Wang

et al. 2005

Clin EEG Neurosci

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The objective of our study was to investigate the effect of topiramate (TPM) on the Lyapunov exponent of EEG by means of quantitative pharmacoelectroencephalography (QPEEG) and nonlinear analysis methods. One dose of TPM was administrated to epileptics and healthy adults. EEG samples were obtained prior to and at regular intervals (at 0.5, 1, 2, 4, 6, 8, 12, 24 hours) within the 24 hours following the administration of TPM. EEG activity was processed with nonlinear analysis methods. The Lyapunov exponent of the scalp areas was calculated through 60 s epochs without artifacts after each recording. The statistical difference between baseline predrug assessment and each postdrug control was calculated by computing the paired t test. Results showed that the Lyapunov exponent increased first, then decreased, then increased finally. We conclude that TPM can change the complexity of EEG.

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Effects of Acute, Oral Administration of Phenobarbital (1.6 mg/kg) to Healthy Subjects

Sannita

Lewine²,

Maclin³

et al. 2000

Biomag 96

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Quantitative EEG Effects and Drug Plasma Concentration of Phenobarbital, 50 and 100 mg Single-Dose Oral Administration to Healthy Volunteers: Evidence of Early CNS Bioavailability

Cited by 10 publications

References 20 publications

Sevoflurane‐induced isoelectricEEGand burst suppression: differential and antagonistic effect of added nitrous oxide

Sevoflurane‐induced isoelectricEEGand burst suppression: differential and antagonistic effect of added nitrous oxide

The Lyapunov Exponent of the EEG after Administration of Topiramate

Effects of Acute, Oral Administration of Phenobarbital (1.6 mg/kg) to Healthy Subjects

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