Abstract:Multi-MUP analysis seems to be helpful in differentiating the patients with neurogenic and-to a lesser extent-myogenic facial muscle involvement.
“…One possible factor is the different architecture and muscle fiber‐type composition of facial muscles compared with limb muscles, which may have an influence on reinnervation processes . MUNIX was “calibrated” for limb muscles (abductor digiti minimi), but very proximal muscles and facial muscles have shorter duration and smaller amplitude MUPs on EMG compared with more distal muscles . However, in a simulation model of MUNIX, simulating lower single MUP amplitudes had no significant influence on MUSIX, but significantly reduced MUNIX values .…”
MUNIX of the nasalis muscle is a reproducible method, but it showed no significant difference between healthy and bulbar ALS subjects and seems not to be a useful marker of disease progression in ALS. Muscle Nerve 54: 733-737, 2016.
“…One possible factor is the different architecture and muscle fiber‐type composition of facial muscles compared with limb muscles, which may have an influence on reinnervation processes . MUNIX was “calibrated” for limb muscles (abductor digiti minimi), but very proximal muscles and facial muscles have shorter duration and smaller amplitude MUPs on EMG compared with more distal muscles . However, in a simulation model of MUNIX, simulating lower single MUP amplitudes had no significant influence on MUSIX, but significantly reduced MUNIX values .…”
MUNIX of the nasalis muscle is a reproducible method, but it showed no significant difference between healthy and bulbar ALS subjects and seems not to be a useful marker of disease progression in ALS. Muscle Nerve 54: 733-737, 2016.
“…In a comparative study, this duration algorithm outperformed the results of conventional methods over normal and pathological signals. However, recent works are still using conventional methods to measure MUAP duration (Ghosh et al, 2014;Matur et al, 2014), sometimes applying manual corrections (Jian et al, 2015).…”
We present a novel automatic method for measuring the duration of motor unit action potentials (MUAPs) and compare it with two state-of-the-art automatic duration methods on normal and pathological MUAPs. To this end we analyzed 313 EMG recordings from normal and pathological muscles during slight contractions. A "gold standard" of the duration positions (start and end markers) was obtained for each MUAP from the manual measurements determined by two expert electromyographists. The results of the novel method were compared to those obtained by the two automatic methods using the "gold standard" duration measures for the different groups of normal and pathological MUAPs. Several statistical tests were applied and showed that the novel method provided closer duration positions to the "gold standard" and fewer gross aberrant errors than those obtained by the two other methods in the four MUAP groups, being significantly different in many of the cases.
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