Quantitative epitope analysis reveals drastic 63% reduced immuno-affinity and 60% enhanced transmissibility for SARS-CoV-2 variants

Brunetti, Giulio; Pastina, Annalisa De; Hegner, Martin

doi:10.1039/d1na00554e

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…And equation (17) represents the nonlocal vibration frequency value derived from the Euler-Bernoulli beam model (EBM), wherein the effects of rotary and shear are disregarded. Numerical results were computed using the Mathlab software environment, considering a varied range of relative distribution density for adatoms, ranging from 0 to 1 for different values of the microbeam length, and fixed value of the residual surface stress of τ 0 = 1.4 N m −1 [40].…”

Section: ⎧ ⎨ ⎩mentioning

confidence: 99%

“…They identified both resonance frequencies and mass distribution over the surface in the presence of bending. Brunetti et al [17], in a significant contribution, derived successful quantification and speciation of nanogram levels of mixtures of similar spike proteins by measuring the shift in microstructure deflection using nanomechanical IR spectroscopy. In another notable investigation, Cao et al [18] explored the interaction of ACE2 with spikes using a microcantilever.…”

Section: Introductionmentioning

confidence: 99%

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Theoretical prediction of proteins network-induced nonlocal response in molecules-resonator biosensor with hydrogen bonds including van der waals interactions

Bourouina,

Boussendel

2024

Phys. Scr.

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This study investigates the dynamic behavior of a biomolecule-resonator system including the shear distortion effect as well as adsorption energy and small scale effects. The nano-object network-induced energy is determined using a distributional approach for both bio-receptor and spike protein where vibration energy model for functional microbeam is derived including surface stress effect. The functional microbeam approach and the localized bio-object approach are applied in conjunction with the van der Waals (vdW) interaction mechanism using Lennard-Jones (6-12) potential to compute the total influence of contributed conditions. Both explicit inertia moment and shear force are developed from the nonlocal Timoshenko beam equations which the residual stress effect is considered as an additive load. Numerical results showed that the computed frequency shift is depended on each of the active surface, localized biomolecules and adsorbed adatoms. Computation indicates that the receptor and spike network should be considered and thus derived model for biosensor micostructure is suitable to investigate the dynamic behavior of the biomolecule-resonator system that can be applied for biosensing technology applications.

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Section: ⎧ ⎨ ⎩mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Theoretical prediction of proteins network-induced nonlocal response in molecules-resonator biosensor with hydrogen bonds including van der waals interactions

Bourouina,

Boussendel

2024

Phys. Scr.

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Silicon microresonator arrays: A comprehensive study on fabrication techniques and pH-controlled stress-induced variations in cantilever stiffness

Brunetti,

De Pastina,

Rotella

et al. 2024

Microelectronic Engineering

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Mutational induction in SARS-CoV-2 major lineages by experimental exposure to neutralising sera

Brandolini

Dirani

Taddei

et al. 2022

Sci Rep

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The ongoing evolution of SARS-CoV-2 and the emergence of new viral variants bearing specific escape mutations responsible for immune evasion from antibody neutralisation has required a more accurate characterisation of the immune response as one of the evolutive forces behind viral adaptation to a largely immunised human population. In this work, culturing in the presence of neutralising sera vigorously promoted mutagenesis leading to the acquisition of known escape mutations on the spike as well as new presumptive escape mutations on structural proteins whose role as target of the neutralizing antibody response might have been thus far widely neglected. From this perspective, this study, in addition to tracing the past evolution of the species back to interactions with neutralising antibody immune response, also offers a glimpse into future evolutive scenarios.

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Quantitative epitope analysis reveals drastic 63% reduced immuno-affinity and 60% enhanced transmissibility for SARS-CoV-2 variants

Abstract: SARS-CoV-2 is the cause of a global pandemic that has led to more than 4 million deaths, continues to spread and holds the world in a tight grip. The virus...

Cited by 4 publications

References 31 publications

Theoretical prediction of proteins network-induced nonlocal response in molecules-resonator biosensor with hydrogen bonds including van der waals interactions

Theoretical prediction of proteins network-induced nonlocal response in molecules-resonator biosensor with hydrogen bonds including van der waals interactions

Silicon microresonator arrays: A comprehensive study on fabrication techniques and pH-controlled stress-induced variations in cantilever stiffness

Mutational induction in SARS-CoV-2 major lineages by experimental exposure to neutralising sera

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