Quantitative Estimation of Relative Contributions of Direct and Indirect Exposures to Perfluorooctane Sulfonate in Organisms Using the Isomer Profiling Technique
Abstract:It
remains a big challenge to estimate the relative importance
of direct vs indirect (via precursors)
exposures of animals and humans to perfluorooctane sulfate (PFOS).
In this study, fish as a biological model were exposed to PFOS and
its typical precursor, perfluorooctane sulfonamide (PFOSA), singly
and combined with different ratios in water for 76 days, followed
by a 21-day depuration. Isomer-specific kinetic parameters including
uptake, elimination, and biotransformation rates as well as bioconcentration
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