1994
DOI: 10.1088/0967-3334/15/1/003
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Quantitative evaluation of aerosol deposition pattern in the lung in patients with chronic bronchitis

Abstract: A number of numeric measurements have been suggested to describe the pattern of deposition of inhaled aerosols, but there is little information about the relationship between the different measurements. We compared four different methods for analysis of aerosol deposition pattern with respect to their ability to separate patients with chronic bronchitis (CB) from healthy subjects, and with respect to their relationship to a simple index of airflow obstruction. Twelve healthy subjects and 22 patients with CB we… Show more

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Cited by 20 publications
(15 citation statements)
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“…In previous studies, radiolabeled albumin spheres were administered along with desired aerosol formulations to determine particle deposition, instead of attaching radionuclides on the inhaled particles of interest (126). However, modern development of sophisticated PET techniques have made it possible to directly label drug particles with positron emitters.…”
Section: In Vivo Experimental Methodsmentioning
confidence: 99%
“…In previous studies, radiolabeled albumin spheres were administered along with desired aerosol formulations to determine particle deposition, instead of attaching radionuclides on the inhaled particles of interest (126). However, modern development of sophisticated PET techniques have made it possible to directly label drug particles with positron emitters.…”
Section: In Vivo Experimental Methodsmentioning
confidence: 99%
“…Gamma scintigraphy can be used to measure the distribution of aerosols within the lung [65][66][67][68]. The lack of spatial resolution of gamma scintigraphy has generally limited the measurement of the distribution of aerosol deposition to statistical metrics, such as the penetration index (the ratio of peripheral to central deposition), the coefficient of variation, the coefficient of skewness and the quotient between maximum and mean value deposition [66]. For example, Laube et al (2000) [69] used gamma scintigraphy to measure the penetration index of radio-aerosol in CF patients.…”
Section: Nuclear Medical Imagingmentioning
confidence: 99%
“…The intrapulmonary aerosol deposition pattern of radioactivity within the right lung was established as a penetration index (PI) defined as the ratio of peripheral to central lung zone deposition (18). Total pulmonary deposition was calculated as the percentage of radioactivity in the right lung multiplied by 1.9, for reasons previously discussed (19).…”
Section: Assessments ( 99m Tc-dtpa Administrations Only)mentioning
confidence: 99%